Zapacid

Description

Zapacid Capsule

Zapacid Capsule, with the generic name Lansoprazole, is a proton pump inhibitor (PPI) manufactured by Win-Medicare Pvt. Ltd. It’s available in Nepal.

Uses (Indications)

Zapacid Capsule is used to treat conditions related to excess stomach acid, including:

• Peptic ulcers (duodenal and gastric ulcers)
• H. pylori infection (in combination therapy)
• Gastro-oesophageal reflux disease (GERD)
• Hypersecretory conditions (e.g., Zollinger-Ellison syndrome)
• Acid-related dyspepsia (indigestion)
• NSAID-induced ulcers (for treatment and prevention)
• Erosive oesophagitis (inflammation and erosion of the esophagus)

How it Works (Mechanism of Action)

Lansoprazole is a substituted benzimidazole, also known as a PPI. It works by blocking the final step of acid secretion by inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells of your stomach. This inhibits both basal (constant) and stimulated acid production.

Dosage Information

Adults:

• Peptic Ulcer:
  • Duodenal Ulcer: 30 mg once daily in the morning for up to 4 weeks.
  • Gastric Ulcer: 30 mg once daily in the morning for up to 8 weeks.
  • Maintenance: 15 mg once daily.
• Zollinger-Ellison Syndrome: Initially, 60 mg once daily in the morning; adjust as needed. For daily doses over 120 mg, take in 2 divided doses.
• Acid-Related Dyspepsia: 15-30 mg once daily in the morning for 2-4 weeks.
• Gastro-oesophageal Reflux Disease (GERD): 15-30 mg once daily in the morning for 4-8 weeks.
  • Maintenance: 15-30 mg once daily, adjusted based on response.
• Prophylaxis of NSAID-induced Ulcers: 15-30 mg once daily in the morning.
• H. pylori Infection (1-week triple therapy): 30 mg twice daily combined with:
  • Clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily, OR
  • Clarithromycin 250 mg twice daily and metronidazole 400 mg twice daily.
• Erosive Oesophagitis: 30 mg once daily in the morning for up to 8 weeks; an additional 8 weeks may be needed if not healed.
  • Maintenance: 15 mg once daily.
• NSAID-Associated Ulceration: 30 mg once daily in the morning for 4-8 weeks.
• Elderly: No dosage adjustment is typically needed.
• Severe Hepatic Impairment: Maximum dose is 30 mg per day.

Children (Oral):

• Gastro-oesophageal Reflux Disease (GERD) & Erosive Oesophagitis:
  • 1-11 years:
    • Weight <30 kg: 15 mg once daily in the morning for up to 12 weeks.
    • Weight >30 kg: 30 mg once daily in the morning for up to 12 weeks.
    • If symptoms persist after 2 or more weeks, doses may be increased up to 30 mg twice daily.
  • 12-17 years: 15 mg once daily for up to 8 weeks for GERD; 30 mg once daily for up to 8 weeks for erosive oesophagitis.

Renal Impairment: No dosage adjustment is needed.

Administration

Take Zapacid Capsule on an empty stomach, before meals.

Important Considerations

Do Not Use If You Have (Contraindications):

• Hypersensitivity (allergy) to Lansoprazole or any of its components.

Use with Caution If You Have (Precautions):

• Hepatic impairment (liver problems).
• Your doctor should rule out gastric malignancy (stomach cancer) before starting treatment.
• Pregnancy and lactation: Use only if clearly needed.
  • Lactation: It’s unknown if Lansoprazole passes into breast milk; breastfeeding is generally not recommended while on this medication.

Potential Drug Interactions

• Increased Risk:
  • Hypomagnesaemia (low magnesium levels) when used with diuretics and digoxin.
  • Plasma concentrations of cilostazol and methotrexate.
• Decreased Plasma Concentration/Effect:
  • Erlotinib, dasatinib, and lapatinib.
  • Bioavailability of itraconazole and ketoconazole.
  • Reduced bioavailability when taken with antacids and sucralfate.
• Potentially Fatal: May significantly decrease serum levels and pharmacological effects of rilpivirine and atazanavir.

Possible Side Effects (Adverse Effects)

Common (1-10%):

• Headache (3-7%)
• Diarrhea (1-5%)
• Constipation (1-5%)
• Nausea (1-3%)
• Abdominal pain (1-3%)

Less Common (<1%):

• Anxiety, angina, palpitations, syncope, edema, anorexia, dry mouth, tenesmus, flatulence, melena, myalgia, tinnitus, allergic reaction.

Disclaimer: This information about Zapacid Capsule is for general knowledge and informational purposes only, and does not constitute medical advice. It is not intended for diagnosis, treatment, or to be a substitute for the professional judgment of a healthcare provider. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.