Sicriptin

Description

Sicriptin Tablet: Your Guide to Use

Sicriptin Tablet is a medication used to treat several conditions, primarily those related to hormone imbalances and Parkinson’s disease. It is indicated for:

• Parkinson’s disease
• Galactorrhea (abnormal breast milk production)
• Hypogonadism (underactive reproductive glands)
• Infertility (in some cases)
• Acromegaly (excess growth hormone)
• Lactation suppression (stopping breast milk production)
• Benign breast and menstrual disorders
• Amenorrhea (absence of menstruation)
• Hyperprolactinemia (high prolactin levels)

How to Use

Sicriptin Tablet should be taken with food.

Adult Dosing:

• Parkinson’s Disease (as an add-on to levodopa):
  • 1st week: 1-1.25 mg at night.
  • 2nd week: 2-2.5 mg at night.
  • 3rd week: 2.5 mg twice daily.
  • 4th week: 2.5 mg three times daily.
  • Then, your doctor may increase as needed.
  • Maintenance dose: 10-40 mg per day.
• Hyperprolactinemia:
  • Initial: 1.25-2.5 mg by mouth once daily.
  • Your doctor may increase the dose by 2.5 mg per day every 2-7 days.
  • Usual therapeutic dose: 5-7.5 mg per day, with a range of 2.5-15 mg per day.
  • Some patients with amenorrhea and/or galactorrhea may use up to 30 mg per day.
• Acromegaly (Parlodel brand, common formulation/usage):
  • Initial: 1.25-2.5 mg by mouth at bedtime for 3 days.
  • Your doctor may increase the dose by 1.25-2.5 mg per day every 3-7 days.
  • Do not exceed 100 mg per day.
• Adjunct to Surgery and Radiotherapy in Acromegaly:
  • Initial: 2.5 mg twice daily.
  • Your doctor may increase slowly as needed, up to 5 mg every 6 hours.
• Lactation Suppression (to stop milk production):
  • 2.5 mg per day for 2-3 days, up to 2.5 mg twice daily for 14 days.
• Prevention of Puerperal Lactation (after childbirth):
  • 2.5 mg on the day of delivery, then 2.5 mg twice daily for 14 days.
• Cyclical Benign Breast and Menstrual Disorders:
  • 2.5 mg twice daily.

Liver Impairment:

• If you have liver impairment, dose adjustments may be necessary. There are no specific guidelines, so your doctor will determine the appropriate dose.

Child Dosing:

• Hyperprolactinemia:
  • 11-15 years: 1.25-2.5 mg by mouth once daily (initially).
  • Maintenance: 2.5-10 mg per day.

Important Considerations

Do Not Use If:

• You have breast carcinoma (breast cancer).
• You are hypersensitive or allergic to bromocriptine, other ergot alkaloids, or any component of the product.
• You have uncontrolled high blood pressure (hypertension).
• You have severe ischemic heart disease (heart disease due to narrowed arteries).
• You are pregnant or breastfeeding.

Precautions:

• Increased Conception Risk: This medication can increase your chances of becoming pregnant.
• Stomach Issues: Use with caution if you have a peptic ulcer or a history of gastrointestinal bleeding.
• Diabetes: Use with caution if you have diabetes or diabetic retinopathy (eye damage from diabetes).
• Organ Impairment: Use with caution if you have impaired liver or kidney function.
• Lung/Heart Issues: Report any new or worsening pleuropulmonary (lung and chest lining) signs and symptoms to your doctor immediately.
• Mental Health: Use with caution if you have a history of psychosis or dementia.
• Cardiovascular Disease: Use with caution if you have cardiovascular disease or are on concurrent antihypertensive therapy (medication for high blood pressure).
• Driving & Operating Machinery: This drug may cause dizziness or drowsiness, which can impair your ability to drive vehicles or operate machinery. Exercise caution.
• Breastfeeding: Sicriptin should not be used during lactation.

Interactions:

• Erythromycin: Taking Sicriptin with erythromycin (an antibiotic) can increase the amount of bromocriptine in your body.
• Alcohol: Alcohol reduces your tolerance to bromocriptine, and vice-versa. Avoid alcohol while on this medication.
• Antihypertensives: The blood pressure-lowering effects of other antihypertensive medications may be increased when taken with Sicriptin.
• Psychotropics: Avoid concurrent use with psychotropic medications (drugs affecting mood, perception, or behavior).

Potential Side Effects

While taking Sicriptin Tablet, you might experience some side effects.

Very Common (More than 10%):

• Nausea (49%)
• Low blood pressure (hypotension) (30%)
• Headache (19%)
• Dizziness (17%)

Common (1-10%):

• Abdominal cramps
• Loss of appetite (anorexia)
• Constipation
• Indigestion (dyspepsia)
• Difficulty swallowing (dysphagia)
• Epigastric pain (upper abdominal pain)
• Gastrointestinal hemorrhage (bleeding in the digestive tract)
• Vomiting
• Drowsiness
• Fatigue
• Faintness
• Visual hallucinations
• Insomnia (difficulty sleeping)
• Lightheadedness
• Nightmares
• Paranoia
• Psychosis
• Seizures
• Vertigo (spinning sensation)
• Arrhythmias (irregular heartbeats)
• Bradycardia (slow heart rate)
• High blood pressure (hypertension)
• Myocardial infarction (heart attack)
• Mottled skin
• Orthostasis (dizziness upon standing)
• Vasospasm (narrowing of blood vessels)
• Palpitations (racing heart)
• Pericardial effusions (fluid around the heart)
• Worsening of Raynaud’s syndrome (poor circulation in fingers/toes)
• Syncope (fainting)
• Blepharospasm (involuntary eyelid twitching)
• Increased BUN (blood urea nitrogen, a kidney function indicator)
• Burning discomfort of the eye
• Double vision (diplopia)
• Facial pallor (paleness)
• Leg cramps
• Nasal congestion
• Rash
• Hives (urticaria)

How It Works

Bromocriptine is a dopamine D2 and D3-agonist. This means it works by activating specific dopamine receptors in your brain (in the tuberoinfundibular and nigrostriatal pathways). By doing this, it helps to:

• Inhibit the secretion of prolactin from the anterior pituitary gland, which is why it’s used for high prolactin levels and related disorders.
• Address symptoms in Parkinson’s disease by mimicking the effects of dopamine, which is deficient in this condition.

Additional Information

Sicriptin 2.87mg Tablet is manufactured by Serum Institute Of India Ltd. Its generic name is Bromocriptine, and it is available in Nepal.