ronafix

Description

Ronafix Capsule (Cefixime)

Ronafix Capsule contains Cefixime 200mg and is produced by Acme Laboratories Ltd. While the retail price isn’t specified, this medication is available in Nepal. Other Cefixime formulations, such as D-SY (dry syrup), are also available under different brands.

Uses (Indications)

Ronafix Capsule is an antibiotic used to treat a variety of bacterial infections, including:

• Respiratory Tract Infections: Pneumonia, pharyngitis, sinusitis, otitis media (ear infection), tonsillitis, acute bronchitis, and acute exacerbations of chronic bronchitis.
• Other Infections: Typhoid fever, susceptible soft tissue infections, and gonococcal urethritis.

Dosage Information

• Adults:
  • For most infections (e.g., acute bronchitis, ear infections, sore throat, uncomplicated urinary tract infections): Take 200 mg or 400 mg daily, either as a single dose or divided into two doses.
  • For Gonorrhea: A single dose of 400 mg.
  • For Typhoid Fever: 20 mg/kg body weight daily, divided into two doses. Treatment typically lasts 7 days but may be extended up to 14 days based on the infection’s severity.
• Children (Oral):
  • General Dosing (for children weighing less than 50 kg): 8 mg/kg/day, given every 12–24 hours.
  • For serious infections (convalescent oral therapy): Up to 20 mg/kg/day.
  • For Powder for Suspension & DS Powder for Suspension (if applicable to this product):
    • Children above 6 months: 8 mg/kg daily in 1-2 divided doses.
    • 6 months – 1 year: 75 mg daily.
    • 1 – 4 years: 100 mg daily.
    • 5 – 10 years: 200 mg daily.
  • For Typhoid Fever: 15-20 mg/kg/day orally, divided every 12 hours for 7-14 days. Do not exceed 400 mg/day.
  • Safety and efficacy are not established for infants under 6 months.
• Renal Impairment: Dose reduction is required. If your creatinine clearance (CrCl) is less than 20 ml/min, the maximum daily dose is 200 mg.

Administration

You can take Ronafix Capsule with or without food. Taking it with food or milk may help reduce any gastrointestinal discomfort.

Important Warnings & Precautions

• Contraindications: Do not use this medication if you have a known hypersensitivity to cephalosporin antibiotics.
• Precautions: Exercise caution if you have a history of allergy to penicillins, are pregnant or breastfeeding (it’s unknown if the drug is excreted in breast milk), have renal failure, or a gastrointestinal disease.
• Drug Interactions:
  • Taking probenecid can increase Cefixime concentrations in your blood.
  • Cefixime may increase prothrombin time with anticoagulants (blood thinners), which could be potentially fatal.
• Side Effects:
  • Common (>10%): Diarrhea (16%).
  • Less Common (Frequency Not Defined): Abdominal pain, candidiasis, dizziness, dyspepsia, elevated liver enzymes (transaminases), eosinophilia, erythema multiforme, fever, flatulence, headache, increased blood urea nitrogen (BUN), increased creatinine, leukopenia, nausea, prolonged prothrombin time (PT), pruritus, pseudomembranous colitis, rash, serum sickness-like reaction, Stevens-Johnson syndrome, thrombocytopenia, urticaria, vaginitis, and vomiting.
  • Potentially Fatal: Pseudomembranous colitis.

How it Works (Mechanism of Action)

Cefixime acts by binding to specific proteins called penicillin-binding proteins (PBPs) within bacterial cell walls. This action inhibits the final transpeptidation step of peptidoglycan synthesis, which is crucial for building the bacterial cell wall. By disrupting this process, Cefixime inhibits biosynthesis and arrests cell wall assembly, ultimately leading to bacterial cell death.

Disclaimer: This information about Ronafix Capsule is intended for general reference only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or medication.