Lanzol

Description

Lanzol Capsule

Lanzol Capsule, with the generic name Lansoprazole, is a proton pump inhibitor (PPI) manufactured by Cipla Ltd. It’s available in Nepal.

Uses (Indications)

Lanzol Capsule is used to treat conditions caused by excessive stomach acid, including:

• Peptic ulcers (duodenal and gastric ulcers)
• H. pylori infection (in combination therapy)
• Gastro-oesophageal reflux disease (GERD)
• Hypersecretory conditions (e.g., Zollinger-Ellison syndrome)
• Acid-related dyspepsia (indigestion)
• NSAID-induced ulcers (from non-steroidal anti-inflammatory drugs)
• Erosive oesophagitis (inflammation and erosion of the esophagus)

How it Works (Mechanism of Action)

Lansoprazole, a substituted benzimidazole, is a proton pump inhibitor (PPI). It works by blocking the final step of acid secretion in your stomach. It does this by inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells, effectively reducing both basal (resting) and stimulated acid production.

Dosage Information

Administration: Lanzol should be taken on an empty stomach, typically before meals.

Adults:

• Peptic Ulcer:
  • Duodenal ulcer: 30 mg once daily in the morning for up to 4 weeks.
  • Gastric ulcer: 30 mg once daily in the morning for up to 8 weeks.
  • Maintenance: 15 mg once daily.
• Zollinger-Ellison Syndrome:
  • Initial: 60 mg once daily in the morning.
  • Adjust dose as needed. Daily doses over 120 mg should be split into two doses.
• Acid-Related Dyspepsia: 15-30 mg once daily in the morning for 2-4 weeks.
• Gastro-oesophageal Reflux Disease (GERD): 15-30 mg once daily in the morning for 4-8 weeks.
  • Maintenance: 15-30 mg once daily, adjusted based on response.
• Prophylaxis of NSAID-Induced Ulcers: 15-30 mg once daily in the morning.
• H. pylori Infection (1-week Triple Therapy): 30 mg twice daily, combined with:
  • Clarithromycin 500 mg twice daily AND Amoxicillin 1 g twice daily, OR
  • Clarithromycin 250 mg twice daily AND Metronidazole 400 mg twice daily.
• Erosive Oesophagitis: 30 mg once daily in the morning for up to 8 weeks. An additional 8 weeks may be needed if not healed.
  • Maintenance: 15 mg once daily.
• NSAID-Associated Ulceration: 30 mg once daily in the morning for 4-8 weeks.

Elderly: No dosage adjustment is typically needed.

Children:

• Gastro-oesophageal Reflux Disease / Erosive Oesophagitis:
  • 1-11 years:
    • Below 30 kg: 15 mg once daily in the morning for up to 12 weeks.
    • Above 30 kg: 30 mg once daily in the morning for up to 12 weeks.
    • Doses can be increased up to 30 mg twice daily if symptoms persist after 2 or more weeks.
  • 12-17 years: 15 mg once daily for up to 8 weeks (for GERD) or 30 mg once daily for up to 8 weeks (for erosive oesophagitis).

Special Populations

• Hepatic Impairment: For severe liver impairment, the maximum dose is 30 mg per day.
• Renal Impairment: No dosage adjustment is needed for kidney impairment.

Important Considerations

Do Not Use If You Have (Contraindications):

• Hypersensitivity to Lansoprazole or any of its components.

Use with Caution If You Have (Precautions):

• Hepatic impairment.
• It’s important to rule out gastric malignancy (stomach cancer) before starting treatment, as Lanzol can mask symptoms.
• Pregnancy and Lactation: Use with caution. It’s not known if Lansoprazole passes into breast milk; nursing is generally not recommended.

Potential Drug Interactions

• Increased Risk of Side Effects:
  • Hypomagnesaemia: Increased risk when taken with diuretics and digoxin.
  • Cilostazol and Methotrexate: May increase their plasma concentrations.
• Decreased Effectiveness of Other Drugs:
  • May decrease the plasma concentration of erlotinib, dasatinib, and lapatinib.
  • May decrease the bioavailability of itraconazole and ketoconazole.
  • Reduced bioavailability when taken with antacids and sucralfate.
• Potentially Fatal Interactions: May decrease the serum levels and pharmacological effects of rilpivirine and atazanavir.

Possible Side Effects (Adverse Effects)

Common (1-10%):

• Headache (3-7%)
• Diarrhea (1-5%)
• Constipation (1-5%)
• Nausea (1-3%)
• Abdominal pain (1-3%)

Less Common (Less than 1%):

• Anxiety, angina, palpitations, syncope, edema, anorexia, dry mouth, tenesmus, flatulence, melena (dark, tarry stools), myalgia (muscle pain), tinnitus (ringing in ears), allergic reaction.

Disclaimer: This information about Lanzol Capsule is for general knowledge and informational purposes only, and does not constitute medical advice. It is not intended for diagnosis, treatment, or to be a substitute for the professional judgment of a healthcare provider. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.