Lanspro

Description

Lanspro Capsule

Lanspro Capsule, with the generic name Lansoprazole, is a proton pump inhibitor (PPI) manufactured by Indchemie Health Specialities Pvt. Ltd. It’s available in Nepal.

Uses (Indications)

Lanspro Capsule is used to treat conditions caused by excessive stomach acid, including:

• Peptic ulcers (duodenal and gastric ulcers)
• H. pylori infection (in combination therapy)
• Gastro-oesophageal reflux disease (GERD)
• Hypersecretory conditions (like Zollinger-Ellison syndrome)
• Acid-related dyspepsia (indigestion)
• NSAID-induced ulcers (ulcers caused by pain relievers) and their prevention
• Erosive oesophagitis (inflammation and damage to the esophagus)

How it Works (Mechanism of Action)

Lansoprazole is a substituted benzimidazole that belongs to the class of proton pump inhibitors (PPIs). It works by blocking the final step of acid secretion in the stomach. It does this by inhibiting the H+/K+ ATPase enzyme system, also known as the “proton pump,” in the gastric parietal cells. This action effectively reduces both basal (normal) and stimulated acid production.

Dosage Information

Lanspro Capsule should be taken on an empty stomach, typically before meals.

Adults:

• Peptic Ulcer:
  • Duodenal Ulcer: 30 mg once daily in the morning for up to 4 weeks.
  • Gastric Ulcer: 30 mg once daily in the morning for up to 8 weeks.
  • Maintenance: 15 mg once daily.
• Zollinger-Ellison Syndrome: Initially, 60 mg once daily in the morning. Doses are adjusted as required. Daily doses greater than 120 mg should be given in two divided doses.
• Acid-Related Dyspepsia: 15-30 mg once daily in the morning for 2-4 weeks.
• Gastro-oesophageal Reflux Disease (GERD): 15-30 mg once daily in the morning for 4-8 weeks.
  • Maintenance: 15-30 mg once daily, adjusted based on response.
• Prophylaxis of NSAID-induced Ulcers: 15-30 mg once daily in the morning.
• H. pylori Infection (1-week triple therapy): 30 mg twice daily, combined with:
  • Clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily, OR
  • Clarithromycin 250 mg twice daily and metronidazole 400 mg twice daily.
• Erosive Oesophagitis: 30 mg once daily in the morning for up to 8 weeks. An additional 8 weeks may be given if the ulcer has not healed.
  • Maintenance: 15 mg once daily.
• NSAID-associated Ulceration: 30 mg once daily in the morning for 4-8 weeks.

Elderly: No dosage adjustment is typically needed.

Hepatic Impairment: For severe hepatic impairment, the maximum dose is 30 mg per day.

Children:

• Gastro-oesophageal Reflux Disease (GERD) & Erosive Oesophagitis:
  • 1-11 years:
    • Weight < 30 kg: 15 mg once daily in the morning for up to 12 weeks.
    • Weight > 30 kg: 30 mg once daily in the morning for up to 12 weeks.
    • Doses may be increased up to 30 mg twice daily if symptoms persist after two or more weeks of treatment.
  • 12-17 years: 15 mg once daily for up to 8 weeks (for GERD). For erosive oesophagitis, 30 mg once daily for up to 8 weeks.

Renal Impairment: No dosage adjustment is typically needed.

Important Considerations

Do Not Use If You Have (Contraindications):

• Hypersensitivity to Lansoprazole or any of its components.

Use with Caution If You Have (Precautions):

• Hepatic impairment: Use with caution if you have liver problems.
• Gastric malignancy: Your doctor should rule out stomach cancer before starting treatment, as Lansoprazole can mask symptoms.
• Pregnancy and Lactation: The effects during pregnancy are not fully established. It is not known whether Lansoprazole is distributed into breast milk, so nursing is generally not recommended.

Potential Drug Interactions

• Increased Risk of Hypomagnesemia: Taking Lansoprazole with diuretics and digoxin may increase the risk of low magnesium levels.
• Decreased Drug Levels: Lansoprazole may decrease the plasma concentration and effectiveness of certain medications like erlotinib, dasatinib, lapatinib, itraconazole, and ketoconazole.
• Increased Drug Levels: Lansoprazole may increase the plasma concentration of cilostazol and methotrexate.
• Reduced Bioavailability: Antacids and sucralfate can reduce the absorption of Lansoprazole.
• Potentially Fatal Interactions: Lansoprazole may significantly decrease the serum levels and pharmacological effects of rilpivirine and atazanavir, which could be fatal.

Possible Side Effects (Adverse Effects)

Common side effects (1-10% occurrence) include:

• Headache (3-7%)
• Diarrhea (1-5%)
• Constipation (1-5%)
• Nausea (1-3%)
• Abdominal pain (1-3%)

Less common side effects (<1% occurrence) include:

• Anxiety, angina (chest pain), palpitations, syncope (fainting), edema (swelling)
• Anorexia (loss of appetite), dry mouth, tenesmus (straining during bowel movements), flatulence (gas), melena (dark, tarry stools)
• Myalgia (muscle pain), tinnitus (ringing in the ears)
• Allergic reactions

Disclaimer: This information about Lanspro Capsule is for general knowledge and informational purposes only, and does not constitute medical advice. It is not intended for diagnosis, treatment, or to be a substitute for the professional judgment of a healthcare provider. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment