Lansopaz

Description

Lansopaz Capsule

Lansopaz Capsule, with the generic name Lansoprazole, is a proton pump inhibitor (PPI) manufactured by CTL Pharmaceuticals Pvt. Ltd. It is available in Nepal.

Uses (Indications)

Lansopaz Capsule is used to treat conditions caused by excessive stomach acid, including:

• Peptic ulcer disease (duodenal and gastric ulcers)
• H. pylori infection (in combination with antibiotics)
• Gastro-oesophageal reflux disease (GERD)
• Hypersecretory conditions (like Zollinger-Ellison syndrome)
• Acid-related dyspepsia (indigestion)
• NSAID-induced ulcers (ulcers caused by non-steroidal anti-inflammatory drugs)
• Erosive oesophagitis (inflammation and damage to the esophagus from acid reflux)

How it Works (Mechanism of Action)

Lansoprazole is a substituted benzimidazole, also known as a PPI. It works by blocking the final step of acid secretion in your stomach. It does this by inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells, effectively reducing both basal (normal) and stimulated (meal-induced) acid production.

Dosage Information

Lansopaz Capsule should be taken on an empty stomach, typically before meals.

Adults:

• Peptic Ulcer:
  • Duodenal Ulcer: 30 mg once daily in the morning for up to 4 weeks.
  • Gastric Ulcer: 30 mg once daily in the morning for up to 8 weeks.
  • Maintenance: 15 mg once daily.
• Zollinger-Ellison Syndrome:
  • Initial: 60 mg once daily in the morning. Doses over 120 mg daily should be divided into two doses. Adjust as needed based on response.
• Acid-Related Dyspepsia: 15-30 mg once daily in the morning for 2-4 weeks.
• Gastro-oesophageal Reflux Disease (GERD): 15-30 mg once daily in the morning for 4-8 weeks.
  • Maintenance: 15-30 mg once daily, adjusted according to your response.
• Prophylaxis of NSAID-induced Ulcers: 15-30 mg once daily in the morning.
• H. pylori Infection (Triple Therapy – 1 week): 30 mg twice daily, combined with:
  • Clarithromycin 500 mg twice daily and Amoxicillin 1 g twice daily, OR
  • Clarithromycin 250 mg twice daily and Metronidazole 400 mg twice daily.
• Erosive Oesophagitis: 30 mg once daily in the morning for up to 8 weeks. An additional 8 weeks may be given if not healed.
  • Maintenance: 15 mg once daily.
• NSAID-Associated Ulceration: 30 mg once daily in the morning for 4-8 weeks.

Elderly: No dosage adjustment is typically needed.

Hepatic Impairment (Severe): Maximum 30 mg per day.

Children:

• Gastro-oesophageal Reflux Disease & Erosive Oesophagitis (1-11 years):
  • Under 30 kg: 15 mg once daily in the morning for up to 12 weeks.
  • Over 30 kg: 30 mg once daily in the morning for up to 12 weeks.
  • Doses can be increased up to 30 mg twice daily if symptoms persist after 2 or more weeks of treatment.
• Gastro-oesophageal Reflux Disease (12-17 years): 15 mg once daily for up to 8 weeks.
• Erosive Oesophagitis (12-17 years): 30 mg once daily for up to 8 weeks.

Renal Impairment: No dosage adjustment is typically needed.

Important Considerations

Do Not Use If You Have (Contraindications):

• A known hypersensitivity (allergic reaction) to Lansoprazole or any of its ingredients.

Use with Caution If You Have (Precautions):

• Liver impairment: Your doctor may adjust your dose.
• Gastric malignancy: Your doctor should rule out stomach cancer before starting treatment as Lansopaz can mask symptoms.
• Pregnancy and Lactation: Use with caution. It’s not known if Lansoprazole passes into breast milk, so nursing is generally not recommended.

Potential Drug Interactions

• Increased Risk of Hypomagnesaemia: When taken with diuretics (water pills) and digoxin.
• Decreased Effectiveness of Other Drugs: May lower blood levels and effectiveness of erlotinib, dasatinib, lapatinib, itraconazole, ketoconazole, rilpivirine, and atazanavir.
• Increased Blood Levels of Other Drugs: May increase blood levels of cilostazol and methotrexate.
• Reduced Bioavailability: Antacids and sucralfate can reduce the absorption of Lansopaz.

Possible Side Effects (Adverse Effects)

Common (1-10%):

• Headache (3-7%)
• Diarrhea (1-5%)
• Constipation (1-5%)
• Nausea (1-3%)
• Abdominal pain (1-3%)

Less Common (less than 1%):

• Anxiety, angina (chest pain), palpitations, syncope (fainting), edema (swelling), anorexia (loss of appetite), dry mouth, tenesmus (straining with bowel movements), flatulence (gas), melena (dark, tarry stools), myalgia (muscle pain), tinnitus (ringing in ears), allergic reactions.

Disclaimer: This information about Lansopaz Capsule is for general knowledge and informational purposes only and does not constitute medical advice. It is not intended for diagnosis, treatment, or to be a substitute for the professional judgment of a healthcare provider. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.