Lan

Description

Lan Capsule

Lan Capsule, with the generic name Lansoprazole, is a proton pump inhibitor (PPI) manufactured by Intas Pharmaceuticals Ltd. It’s available in Nepal.

Uses (Indications)

Lan Capsule is used to treat conditions caused by excessive stomach acid, including:

• Peptic ulcers (duodenal and gastric ulcers)
• H. pylori infection (in combination therapy)
• Gastro-oesophageal reflux disease (GERD)
• Hypersecretory conditions (e.g., Zollinger-Ellison syndrome)
• Acid-related dyspepsia (indigestion)
• NSAID-induced ulcers (ulcers caused by non-steroidal anti-inflammatory drugs)
• Erosive oesophagitis (inflammation and erosion of the esophagus)

How it Works (Mechanism of Action)

Lansoprazole, a substituted benzimidazole and a type of PPI, works by blocking the final step of acid secretion in the stomach. It does this by inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells. This action effectively reduces both basal (resting) and stimulated acid production.

Dosage Information

Administration: Take Lan Capsule on an empty stomach, before meals.

Adults (Oral):

• Peptic Ulcer:
  • Duodenal ulcer: 30 mg once daily in the morning for up to 4 weeks.
  • Gastric ulcer: 30 mg once daily in the morning for up to 8 weeks.
  • Maintenance: 15 mg once daily.
• Zollinger-Ellison Syndrome: Initially, 60 mg once daily in the morning. Adjust the dose as needed. Daily doses over 120 mg should be divided into two doses.
• Acid-Related Dyspepsia: 15-30 mg once daily in the morning for 2-4 weeks.
• Gastro-oesophageal Reflux Disease (GERD): 15-30 mg once daily in the morning for 4-8 weeks.
  • Maintenance: 15-30 mg once daily, adjusted based on response.
• Prophylaxis of NSAID-induced Ulcers: 15-30 mg once daily in the morning.
• H. pylori Infection (1-week triple therapy): 30 mg twice daily, combined with:
  • Clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily, OR
  • Clarithromycin 250 mg twice daily and metronidazole 400 mg twice daily.
• Erosive Oesophagitis: 30 mg once daily in the morning for up to 8 weeks; an additional 8 weeks may be given if not healed.
  • Maintenance: 15 mg once daily.
• NSAID-associated Ulceration: 30 mg once daily in the morning for 4-8 weeks.
• Elderly: No dosage adjustment is typically needed.
• Severe Hepatic Impairment: Maximum daily dose is 30 mg.

Children (Oral):

• Gastro-oesophageal Reflux Disease (GERD) & Erosive Oesophagitis:
  • 1-11 years:
    • Weight <30 kg: 15 mg once daily in the morning for up to 12 weeks.
    • Weight >30 kg: 30 mg once daily in the morning for up to 12 weeks.
    • If symptoms persist after 2 or more weeks of treatment, doses may be increased up to 30 mg twice daily.
  • 12-17 years: 15 mg once daily for up to 8 weeks (for GERD); 30 mg once daily for up to 8 weeks (for erosive oesophagitis).

Renal Impairment: No dosage adjustment is needed.

Important Considerations

Do Not Use If You Have (Contraindications):

• Known hypersensitivity to Lansoprazole or any of its components.

Use with Caution If You Have (Precautions):

• Hepatic impairment (liver problems).
• Your doctor should rule out a gastric malignancy (stomach cancer) before starting treatment.
• Pregnancy and lactation: It’s not known if Lansoprazole is distributed into breast milk; therefore, it’s advised not to nurse while taking this medication.

Potential Drug Interactions

• Increased risk of hypomagnesaemia (low magnesium levels) with diuretics and digoxin.
• May decrease the plasma concentration of erlotinib, dasatinib, and lapatinib.
• May decrease the bioavailability of itraconazole and ketoconazole.
• May increase the plasma concentration of cilostazol and methotrexate.
• Reduced bioavailability with antacids and sucralfate.
• Potentially Fatal: May decrease serum levels and pharmacological effects of rilpivirine and atazanavir.

Possible Side Effects (Adverse Effects)

Common (1-10%):

• Headache (3-7%)
• Diarrhea (1-5%)
• Constipation (1-5%)
• Nausea (1-3%)
• Abdominal pain (1-3%)

Less Common (<1%):

• Anxiety, angina (chest pain), palpitations, syncope (fainting), edema (swelling), anorexia (loss of appetite), dry mouth, tenesmus (straining sensation), flatulence (gas), melena (dark stools), myalgia (muscle pain), tinnitus (ringing in ears), allergic reactions.

Disclaimer: This information about Lan Capsule is for general knowledge and informational purposes only and does not constitute medical advice. It is not intended for diagnosis, treatment, or to be a substitute for the professional judgment of a healthcare provider. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.