Kafxim

Description

Kafxim DT Tablet

Generic Name: Cefixime

Manufacturer: Mark Ltd. (Available in Nepal)

Uses

Kafxim DT Tablet is prescribed for various susceptible bacterial infections, including:

• Respiratory Infections: Pneumonia, sinusitis, pharyngitis, tonsillitis, acute bronchitis, and acute exacerbations of chronic bronchitis.
• Ear Infections: Otitis media.
• Other Infections: Typhoid fever, soft tissue infections, uncomplicated urinary tract infections, and uncomplicated gonococcal urethritis.

Dosing Information

You can take Kafxim DT with or without food. Taking it with food or milk might help reduce gastrointestinal discomfort.

Adult Dosing

• For most infections (acute bronchitis, acute exacerbations of chronic bronchitis, otitis media, pharyngitis/tonsillitis, uncomplicated urinary tract infections): Take 200 mg or 400 mg once daily, or split into two divided doses.
• For gonorrhea: Take a single dose of 400 mg.
• For typhoid fever: Take 20 mg/kg of body weight daily, divided into two doses. Treatment usually lasts 7 days, but your doctor might extend it up to 14 days depending on how severe your infection is.

Child Dosing

• For children weighing less than 50 kg: Give 8 mg/kg daily by mouth, either once a day or split into two doses (every 12 to 24 hours).
• For serious infections requiring follow-up oral treatment: Doses can go up to 20 mg/kg daily.

Dosing for Powder for Suspension & DS Powder for Suspension:

• Children above 6 months: 8 mg/kg daily, divided into 1-2 doses.
• 6 months to 1 year: 75 mg daily.
• 1-4 years: 100 mg daily.
• 5-10 years: 200 mg daily.

For Typhoid Fever in Children:

• Give 15-20 mg/kg/day by mouth, divided every 12 hours, for 7-14 days. Do not exceed 400 mg/day.

Important Note: The safety and efficacy of Kafxim DT have not been established for children younger than 6 months.

Dosing for Kidney Problems

If you have kidney impairment, your doctor will need to adjust your dose.

• Creatinine Clearance (CrCl) less than 20 ml/min: The maximum dose is 200 mg daily.

Important Considerations

Do Not Use If:

• You are allergic to cephalosporin antibiotics.

Use With Caution If You Have:

• A history of allergic reactions to penicillins.
• Kidney failure.
• Gastrointestinal disease.

Pregnancy & Breastfeeding:

• Pregnancy: Use with caution.
• Breastfeeding: It’s not known if Cefixime passes into breast milk.

Drug Interactions

• Probenecid: Can increase the concentration of Cefixime in your body.
• Anticoagulants (blood thinners): Kafxim DT may increase your risk of bleeding by prolonging prothrombin time. This interaction can be serious.

Possible Side Effects

Very Common (More than 10% of people):

• Diarrhea (16%)

Other Side Effects (Frequency Not Defined):

• Abdominal pain, candidiasis (yeast infection), dizziness, dyspepsia (indigestion), elevated transaminases (liver enzymes), eosinophilia (increased white blood cells), erythema multiforme (a severe skin reaction), fever, flatulence (gas), headache, increased blood urea nitrogen (BUN) and creatinine levels, leukopenia (low white blood cell count), nausea, prolonged prothrombin time (PT), pruritus (itching), pseudomembranous colitis (a serious colon inflammation), rash, serum sickness-like reaction (a severe allergic reaction), Stevens-Johnson syndrome (another severe skin reaction), thrombocytopenia (low platelet count), urticaria (hives), vaginitis (vaginal inflammation), and vomiting.

Potentially Life-Threatening Side Effect:

• Pseudomembranous colitis.

How Kafxim Works

Kafxim (Cefixime) is an antibiotic that works by interfering with the synthesis of the bacterial cell wall. It binds to specific proteins called penicillin-binding proteins (PBPs), which are essential for building and maintaining the cell wall. By inhibiting this process, Kafxim prevents the bacteria from forming a complete cell wall, ultimately leading to bacterial cell death.