Infixime

Description

Infixime Tablet

Generic Name: Cefixime

Manufacturer: Asian Pharmaceuticals Pvt. Ltd. (Nepal)

Indications

Infixime Tablet is used to treat a variety of susceptible bacterial infections, including:

• Respiratory Tract Infections: Pneumonia, Pharyngitis, Sinusitis, Tonsillitis, Acute Bronchitis, Acute Exacerbations of Chronic Bronchitis.
• Ear Infections: Otitis Media.
• Soft Tissue Infections.
• Typhoid Fever.
• Gonococcal Urethritis (uncomplicated).
• Uncomplicated Urinary Tract Infections.

Dosage and Administration

Infixime may be taken with or without food. Taking it with food or milk may help reduce gastrointestinal discomfort.

Adult Dose

• Acute Bronchitis, Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated Urinary Tract Infections: 200 mg or 400 mg daily, as a single dose or in two divided doses.
• Gonorrhea: 400 mg as a single dose.
• Typhoid Fever: 20 mg/kg body weight daily in two divided doses. The usual treatment duration is 7 days, and may be extended up to 14 days based on infection severity.

Child Dose

• For children weighing less than 50 kg: 8 mg/kg/day orally, administered every 12 to 24 hours.
• For convalescent oral therapy of serious infections: Up to 20 mg/kg/day.

Powder for Suspension & DS Powder for Suspension (Children):

• Children above 6 months: 8 mg/kg daily in 1-2 divided doses.
• 6 months – 1 year: 75 mg daily.
• 1-4 years: 100 mg daily.
• 5-10 years: 200 mg daily.

Typhoid Fever (Children):

• 15-20 mg/kg/day orally, divided every 12 hours for 7-14 days. Do not exceed 400 mg/day.

Note: Safety and efficacy have not been established for children under 6 months of age.

Renal Dose

Dose reduction is necessary for patients with renal impairment:

• Creatinine Clearance (CrCl) < 20 ml/min: Maximum 200 mg daily.

Contraindications

• Hypersensitivity to cephalosporins.

Precautions

Exercise caution in patients with:

• A history of allergy to penicillins.
• Renal failure.
• Gastrointestinal disease.

Pregnancy and Lactation:

• Pregnancy: Use with caution.
• Lactation: It is unknown whether Cefixime is excreted in breast milk.

Interactions

• Probenecid: May increase Cefixime concentrations.
• Anticoagulants: May potentially increase prothrombin time. (Potentially Fatal)

Adverse Effects

Common ( >10%):

• Diarrhea (16%)

Frequency Not Defined (may include, but are not limited to):

• Abdominal pain
• Candidiasis
• Dizziness
• Dyspepsia
• Elevated transaminases
• Eosinophilia
• Erythema multiforme
• Fever
• Flatulence
• Headache
• Increased blood urea nitrogen (BUN)
• Increased creatinine
• Leukopenia
• Nausea
• Prolonged prothrombin time (PT)
• Pruritus
• Rash
• Serum sickness-like reaction
• Stevens-Johnson syndrome
• Thrombocytopenia
• Urticaria
• Vaginitis
• Vomiting

Potentially Fatal:

• Pseudomembranous colitis.

Mechanism of Action

Cefixime works by binding to penicillin-binding proteins (PBPs) in bacterial cells. This action inhibits the final transpeptidation step of peptidoglycan synthesis, which is crucial for bacterial cell wall formation. By disrupting cell wall assembly, Cefixime causes bacterial cell death.

Disclaimer: This information about Infixime Tablet is for general knowledge and is not intended for diagnosis, medical advice, or treatment. It should not be considered a substitute for professional medical judgment.