Infexim

Description

Infexim D-SY (Cefixime)

Infexim D-SY is an antibiotic manufactured by Asian Pharmaceuticals Pvt. Ltd. and available in Nepal. Its generic name is Cefixime.

Availability & Pricing

Infexim D-SY is available as a suspension in two pack sizes:

• 30ml: Retail Price: ₨ 58.00 NPR
• 60ml: Retail Price: ₨ 120.00 NPR

Other brands of Cefixime are also available in various strengths and forms, including:

• 50mg – DT Tablet
• 50mg – Tablet
• 100mg – Tablet
• 200mg – Tablet
• 400mg – Tablet

Indications: What is Infexim D-SY used for?

Infexim D-SY is used to treat a variety of bacterial infections, including:

• Respiratory Tract Infections: Pneumonia, Pharyngitis, Sinusitis, Otitis media, Tonsillitis, Acute Bronchitis, and Acute Exacerbations of Chronic Bronchitis.
• Other Susceptible Infections: Typhoid fever, Soft tissue infections, and Gonococcal urethritis.

Dosage Information

Adult Dose:

• Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated Urinary Tract Infections: 200 mg or 400 mg daily, taken as a single dose or divided into two doses.
• Gonorrhea: A single dose of 400 mg.
• Typhoid Fever: 20 mg/kg body weight daily, divided into two doses. The usual treatment duration is 7 days, but it may be extended up to 14 days depending on the severity of the infection.

Child Dose (Oral):

• General Dosing (for children weighing <50 kg): 8 mg/kg/day, given every 12–24 hours.
• Convalescent Oral Therapy for Serious Infections: Up to 20 mg/kg/day.

Specific Dosing for Powder for Suspension & DS Powder for Suspension:

• Children above 6 months: 8 mg/kg daily in 1-2 divided doses.
• 6 months – 1 year: 75 mg daily.
• 1 – 4 years: 100 mg daily.
• 5 – 10 years: 200 mg daily.

Typhoid Fever (Child Dose):

• 15-20 mg/kg/day orally, divided every 12 hours for 7-14 days. Do not exceed 400 mg/day.
• Note: Safety and efficacy have not been established for children under 6 months of age.

Renal Dose:

• Renal Impairment: Dose reduction is necessary.
• Creatinine Clearance (CrCl) <20 ml/min: Maximum dose is 200 mg daily.

Administration

Infexim D-SY can be taken with or without food. Taking it with food or milk may help reduce gastrointestinal discomfort.

Contraindications

Do not use Infexim D-SY if you have a known hypersensitivity to cephalosporin antibiotics.

Precautions

Exercise caution if you have:

• A history of allergy to penicillins.
• Pregnancy and Lactation: It’s unknown whether the drug is excreted in breast milk.
• Renal failure.
• Gastrointestinal disease.

Interactions

• Increased Drug Concentrations: Levels of Cefixime may increase when taken with probenecid.
• Potentially Fatal Interaction: Cefixime may increase prothrombin time when taken with anticoagulants.

Adverse Effects (Side Effects)

Common Side Effects (>10%):

• Diarrhea (16%)

Less Common Side Effects (Frequency Not Defined):

• Abdominal pain
• Candidiasis
• Dizziness
• Dyspepsia
• Elevated transaminases
• Eosinophilia
• Erythema multiforme
• Fever
• Flatulence
• Headache
• Increased blood urea nitrogen (BUN)
• Increased creatinine
• Leukopenia
• Nausea
• Prolonged prothrombin time (PT)
• Pruritus
• Rash
• Serum sickness-like reaction
• Thrombocytopenia
• Urticaria
• Vaginitis
• Vomiting

Potentially Fatal Adverse Effect:

• Pseudomembranous colitis

Mechanism of Action

Cefixime works by binding to penicillin-binding proteins (PBPs) in bacterial cell walls. This action inhibits the final step of peptidoglycan synthesis, which is crucial for bacterial cell wall formation. By disrupting cell wall assembly, Cefixime ultimately leads to bacterial cell death.

Important Note: The information provided here about Infexim D-SY is for general knowledge and is not intended for diagnosis, medical advice, or treatment. It should not be used as a substitute for professional medical judgment. Always consult with a healthcare professional for any health concerns or before making any decisions related to your health or treatment.