HUMINSULIN 30/70 VIAL (40IU/ML)

HUMINSULIN 30/70 VIAL (40IU/ML): A Premixed Insulin for Diabetes Management

HUMINSULIN 30/70 Vial (40IU/ML) is a premixed suspension of human insulin, used for the treatment of diabetes mellitus (both Type 1 and Type 2) in adults and children. This formulation provides a convenient way to manage blood sugar levels by combining both a short-acting (soluble) insulin and an intermediate-acting (isophane NPH) insulin in a single injection. The “30/70” indicates the ratio: 30% short-acting insulin and 70% intermediate-acting insulin. The “40IU/ML” specifies its concentration – 40 International Units of insulin per milliliter, which requires a specific U-40 syringe for accurate dosing.

How it Works: A Dual Action Approach

HUMINSULIN 30/70 works by mimicking the body’s natural insulin response to control blood glucose levels. Its effectiveness comes from its two components:

• 30% Soluble Human Insulin (Short-Acting): This part begins to lower blood sugar levels relatively quickly, typically within 30 minutes after injection. It’s designed to manage the rapid rise in blood glucose that occurs after meals.
• 70% Isophane Human Insulin (NPH – Intermediate-Acting): This component has a prolonged action. It is combined with protamine to slow its absorption, providing a more sustained effect. This part helps to control blood sugar levels between meals and overnight, offering a basal level of insulin.

Together, these two insulins work to provide both immediate mealtime coverage and longer-lasting background glucose control, simplifying the insulin regimen for many patients.

Onset, Peak, and Duration of Action:

While individual responses can vary, generally for premixed human insulins like Huminsulin 30/70:

• Onset of Action: Approximately 30-60 minutes after injection.
• Peak Effect: Typically between 2 and 8 hours after injection.
• Duration of Action: Can last for about 18 to 24 hours.

Key Features and Benefits:

• Convenience: The premixed formulation reduces the number of injections needed daily compared to separate short-acting and intermediate-acting insulins.
• Comprehensive Control: Addresses both post-meal glucose spikes and provides sustained basal insulin coverage.
• Established Efficacy: Human insulins have a long history of safe and effective use in diabetes management.
• Vial Format: Allows for withdrawal of insulin using a syringe, offering flexibility in dosing based on specific prescription (it’s crucial to use a U-40 syringe for this specific concentration).

Important Usage and Administration:

• Subcutaneous Injection: HUMINSULIN 30/70 is administered by injecting it under the skin (subcutaneously). Common injection sites include the abdominal wall, thigh, upper arm, or buttocks.
• Thorough Mixing is CRUCIAL: As it is a suspension, the vial must be gently rolled between the palms at least 10 times and inverted 10 times immediately before every injection until the contents are uniformly mixed (appearing uniformly cloudy white or milky). Do not shake vigorously, as this can create foam and affect dose accuracy.
• Specific Syringe Required (U-40): The “40IU/ML” concentration means that you must use a U-40 insulin syringe for accurate dosing. Using a U-100 syringe (the most common type) with U-40 insulin will result in an incorrect and potentially dangerous dose. Always confirm you have the correct syringe for your insulin concentration.
• Timing of Injection: It is typically administered approximately 30 minutes before a meal. Ensure a meal containing carbohydrates is consumed within this timeframe.
• Injection Site Rotation: To prevent skin issues like lipodystrophy (thickening or pitting of the skin), it is essential to rotate injection sites regularly within the chosen injection area.
• Never Share: Vials and syringes are for single-patient use only. Sharing can lead to the transmission of infections.

Storage:

• Unopened Vials: Should be stored in a refrigerator (2°C – 8°C). Do not freeze. Do not use if the insulin has been frozen.
• Opened (In-Use) Vials: Once opened, the vial can be kept at room temperature (below 30°C) for up to 28 days (4 weeks). Protect it from light and excessive heat. Do not refrigerate an in-use vial.
• Inspect Before Use: Always visually inspect the insulin before each use. After mixing, it should appear uniformly cloudy. Do not use if it looks clear, contains particles, or is discolored.

Potential Side Effects:

The most common and serious side effect is hypoglycemia (low blood sugar). Symptoms can include:

• Sweating, cold sweats
• Shakiness, trembling
• Dizziness, lightheadedness, headache
• Confusion, irritability, anxiety
• Rapid heartbeat
• Hunger
• Blurred vision

It is vital to recognize and treat hypoglycemia promptly by consuming a fast-acting source of sugar (e.g., glucose tablets, fruit juice, regular soda).

Other possible side effects include:

• Injection site reactions: Pain, redness, itching, swelling, or bruising at the injection site.
• Lipodystrophy: Changes in the fatty tissue under the skin at injection sites (lumps or depressions) if sites are not rotated.
• Weight gain.
• Fluid retention (edema), particularly in the hands or feet.
• Allergic reactions: Rarely, severe allergic reactions (e.g., widespread rash, difficulty breathing, wheezing, significant drop in blood pressure) can occur and require immediate medical attention.
• Hypokalemia (low blood potassium): Insulin can cause a shift of potassium into cells.

Important Warnings and Precautions:

• Dose Accuracy: Always double-check your dose and ensure you are using the correct U-40 syringe for this specific concentration (40IU/ML). Medication errors related to insulin concentration are a significant risk.
• Blood Glucose Monitoring: Regular monitoring of blood glucose levels is essential to adjust insulin doses and prevent both hypoglycemia and hyperglycemia.
• Medical Supervision: Always use HUMINSULIN 30/70 under the guidance of a healthcare professional. Do not change your dose or type of insulin without consulting your doctor.
• Interactions: Inform your doctor about all medications you are taking, as some drugs can affect blood sugar levels and may require insulin dose adjustments.
• Alcohol Consumption: Alcohol can significantly affect blood sugar levels and increase the risk of hypoglycemia.
• Driving/Operating Machinery: Be cautious if you experience symptoms of hypoglycemia, as your ability to concentrate and react may be impaired.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as insulin needs may change.

HUMINSULIN 30/70 Vial (40IU/ML) is an effective tool in managing diabetes, but careful adherence to its specific administration instructions, vigilant blood glucose monitoring, and regular consultation with your healthcare provider are crucial for safe and optimal outcomes.