₨ NPR
Flubex
Flubex Capsule (Flucloxacillin 500mg)
Manufactured by: Beximco Pharmaceuticals Ltd. Price in Damak, Koshi Province, Nepal: NPR 23.50
This capsule contains Flucloxacillin, an antibiotic mainly for infections caused by Staphylococci.
What it Treats:
- Respiratory: Pneumonia, Sinusitis, Tonsillitis.
- Skin/Tissue: Staph skin infections, Boils, Wounds, Abscesses, Infected eczema/acne, Burns.
- Serious Infections: Meningitis, Endocarditis, Septicaemia, Osteomyelitis, Enteritis.
- Prevention: Surgical Prophylaxis.
How to Take:
- Adults (Oral): 250-500mg, 3-4 times daily.
- Adults (IV): 0.25-1g, 4 times daily (higher for severe cases/specific infections).
- Children: Doses based on weight (12.5-25 mg/kg body weight, 4 times daily orally; half/quarter adult IV dose for older/younger children).
- Take on an empty stomach, 30-60 minutes before meals.
- Kidney Impairment: Dose adjustment may be needed.
Important Warnings:
- Do not use if allergic to penicillins or have porphyria.
- Use with caution in poor kidney function or heart failure.
- Not recommended for pregnancy or breastfeeding without doctor’s advice.
- Can interact with other drugs like warfarin, oral contraceptives, and methotrexate.
Possible Side Effects:
Commonly include allergic reactions (rashes, fever), GI upset, and blood disorders. Serious but rare side effects include severe skin reactions (Stevens-Johnson syndrome) and anaphylaxis
₨23.50
Ask about productDescription
Flubex Capsule
Flucloxacillin
500mg
Beximco Pharmaceuticals Ltd.
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| Retail Price | 23.50 NPR |
Indications
Flubex Capsule is used for: Pneumonia, Burns, Meningitis, Endocarditis, Sinusitis, Septicaemia, Tonsillitis, Surgical Prophylaxis, Staphylococcal skin infections, Boils, Osteomyelitis, Enteritis,Wounds, Abscesses, Infected eczema, Infected acne
Adult Dose
Adults (including elderly patients): Oral: 250-500mg three to four times a day. Intravenous IV 0.25-1 g 4 times/day, may double in severe cases. Up to 8 g/day in 3-4 divided doses may be given for osteomyelitis. Up to 8 g/day in 4 divided doses for endocarditis in patients weighing <85 kg and 12 g/day in 6 divided doses for patients weighing >85 kg.
Child Dose
Children have been given doses of 12.5-25 mg/kg body weight four times a day. Intravenous 2-10 years: Half of adult dose Under 2 years: One fourth of adult dose
Renal Dose
Renal impairment: CrCl (ml/min) <10 Dosage adjustment may be necessary.
Administration
Should be taken on an empty stomach. Take on an empty stomach ½-1 hr before meals. Reconstitution: Dissolve 250-500 mg in 5-10 mL water for inj or 1 g in 15-20 mL water for inj. For IV infusion, further dilute in suitable IV fluids (e.g. water for inj, NaCl 0.9%, glucose 5%, NaCl 0.18% w/ glucose 4%).
Contra Indications
Hypersensitivity to penicillins. Porphyria.
Precautions
Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route; elderly. Hepatic impairment.
Pregnancy-Lactation
Interactions
May increase the risk of methotrexate toxicity. May decrease the efficacy of oestrogen-containing OC. Enhanced plasma concentrations w/ probenecid. Bacteriostatic drugs (e.g. chloramphenicol, tetracycline) may interfere w/ the bactericidal effect of flucloxacillin. May prolong bleeding time in patients on oral anticoagulants.
Adverse Effects
Side effects of Flucloxacillin : Hypersensitivity reactions including urticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis; hepatitis, cholestatic jaundice; agranulocytosis; phlebitis (IV infusion). Potentially Fatal: Anaphylaxis. Stevens-Johnson syndrome
Mechanism of Action
Flucloxacillin inhibits the 3rd and last step of bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. It is active against penicillinase-producing and non-penicillinase-producing staphylococci.
Note
Flubex 500mg Capsule manufactured by Beximco Pharmaceuticals Ltd.. Its generic name is Flucloxacillin. Flubex is availble in Nepal. Farmaco Nepal drug index information on Flubex Capsule is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
Additional information
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