DOX CTL

Description

Here’s a rewritten version of the information about DOX CTL Capsule, aiming for clarity, conciseness, and an engaging tone:

DOX CTL Capsule (Doxycycline 100mg)

Manufactured by: CTL Pharmaceuticals Pvt. Ltd. Retail Price: NPR 6.00 Available as: 100mg Capsule

What is DOX CTL Capsule Used For?

DOX CTL Capsule, containing Doxycycline, is a versatile antibiotic used to treat a wide range of bacterial infections. It’s commonly prescribed for:

• Acne & Rosacea: Helps manage inflammatory skin conditions.
• Various Infections: Effective against susceptible bacterial infections, including those affecting the respiratory tract.
• Sexually Transmitted Diseases (STDs): Treats uncomplicated gonorrhea, Chlamydia infections, and syphilis (especially for those allergic to penicillin).
• Rickettsial Infections: Addresses diseases like Rocky Mountain spotted fever and typhus.
• Malaria Prophylaxis: Used to prevent malaria, particularly for travelers to high-risk areas.
• Other Conditions: Also indicated for brucellosis, cholera, acute bacterial rhinosinusitis, anthrax post-exposure, and as an adjunctive therapy for intestinal amebiasis and certain cases of infective endocarditis.

How to Take DOX CTL Capsule

Adult Dosing:

• General Infections: Typically, 200 mg on the first day (single or divided doses), followed by 100 mg once daily. For severe infections, the initial dose may be maintained.
• Sexually Transmitted Diseases (STDs):
  • Uncomplicated Gonorrhea/Chlamydia: 100 mg by mouth twice daily for 7 days.
  • Syphilis (Early, Penicillin-Allergic): 100 mg by mouth twice daily for 2 weeks.
  • Syphilis (Duration >1 year, Penicillin-Allergic): 100 mg by mouth twice daily for 4 weeks.
  • Acute Epididymo-orchitis: 100 mg by mouth twice daily for at least 10 days.
• Acne, Rosacea: 50 mg daily for 6-12 weeks.
• Malaria Prophylaxis: 100 mg by mouth once daily, starting 1-2 days before travel and continuing daily during travel, plus 4 weeks after leaving the malaria-infested area.
• Intestinal Amebiasis, Respiratory Tract Infections, Rickettsial Infections: 100 mg by mouth twice daily on day 1, then 100 mg once daily.
• Brucellosis: 100 mg by mouth twice daily for 6 weeks, in combination with rifampin or streptomycin.
• Cholera: 300 mg by mouth once (as an adjunct to fluid and electrolyte replacement).
• Acute Bacterial Rhinosinusitis: 200 mg/day by mouth (once daily or divided twice daily) for 5-7 days.
• Anthrax (Post-exposure prophylaxis): 100 mg by mouth twice daily for 60 days.
• Infective Endocarditis (Bartonella): 100 mg by mouth twice daily for 6 weeks, often combined with other antibiotics (gentamicin, ceftriaxone, or rifampin).

Child Dosing:

• For children over 8 years old and under 45 kg: 2–4 mg/kg per day, divided every 12 hours.

Important Administration Notes:

• DOX CTL can be taken with or without food.
• Always take it with a full glass of water and remain upright for at least 30 minutes after taking to prevent esophageal irritation.
• If you experience stomach upset (GI irritation), try taking it with food or milk.

Important Considerations & Warnings

Do Not Use If:

• You have a known allergy to doxycycline or any tetracycline antibiotics.
• You have a severe liver disorder.
• You have systemic lupus erythematosus.
• You are taking alkalis, antacids, or iron supplements concurrently, as these can reduce absorption.
• It’s generally advised to avoid concurrent use with penicillin.

Special Precautions:

• Tooth Discoloration: Doxycycline (and other tetracyclines) can cause permanent tooth discoloration in children under 12 and during the last half of pregnancy. It should only be used in these age groups if other treatments are ineffective or contraindicated.
• Pregnancy & Breastfeeding:
  • Pregnancy: Generally not recommended during pregnancy unless your doctor determines it’s absolutely essential for your health.
  • Lactation: Doxycycline enters breast milk and is therefore not recommended for breastfeeding mothers.
• Drug Interactions:
  • Avoid concurrent use with isotretinoin due to a risk of pseudotumor cerebri.
  • Can increase the effect of blood thinners like warfarin.
  • May reduce the effectiveness of penicillin and oral contraceptives.
  • Absorption can be impaired by antacids (aluminum, calcium, magnesium), zinc, iron, and bismuth preparations.
  • Metabolism can be increased by phenobarbital, carbamazepine, primidone, and phenytoin.
  • Can increase cyclosporine levels.
  • Concurrent use with methoxyflurane (an anesthetic) can be fatal due to severe kidney toxicity.

Potential Side Effects

Like all medications, DOX CTL can cause side effects. Some common and serious ones include:

Common/Less Severe:

• Headache, blurred vision, ringing in ears
• Stomach pain, nausea, vomiting, diarrhea, indigestion
• Esophageal ulceration, tooth discoloration
• Rashes, sensitivity to sunlight (photosensitivity)
• Joint and muscle pain
• Vaginitis

Serious (Seek immediate medical attention if you experience):

• Severe Allergic Reactions: Anaphylactoid reactions, angioneurotic edema (swelling of face/throat), difficulty breathing, severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis).
• Liver Problems: Jaundice, transient increases in liver function tests, hepatotoxicity (potentially fatal).
• Kidney Problems: Increased BUN (blood urea nitrogen).
• Blood Disorders: Hemolytic anemia, thrombocytopenia, neutropenia, porphyria, eosinophilia.
• Intracranial Hypertension: Increased pressure in the head (can cause bulging soft spot in infants, severe headache, vision changes in adults).
• Clostridium difficile-Associated Disease (CDAD): Severe diarrhea.

How Does DOX CTL Work? (Mechanism of Action)

Doxycycline works by stopping bacteria from producing essential proteins needed for their growth and multiplication. It attaches to a specific part of bacterial cells (the 30S ribosomal subunit), which prevents protein synthesis. This action makes it effective against a broad range of Gram-positive and Gram-negative bacteria.

Disclaimer: This information about DOX CTL 100mg Capsule is for informational purposes only and is not intended as medical advice. Always consult with a healthcare professional for diagnosis, treatment, and any questions regarding your medical condition or medication.