Dortsil

Description

Dortsil Tablet: Quick Guide

Dortsil Tablet is an antispasmodic medication available in Nepal, manufactured by Psycormedies. Its active ingredient is Drotaverine Hydrochloride.

What is it used for?

Dortsil Tablet is used to relieve muscle spasms and associated pain in various conditions, including:

• Gastrointestinal (GI) tract spasms
• Irritable Bowel Syndrome (IBS)
• Dysmenorrhea (painful menstrual periods)
• Biliary colics (pain related to the gallbladder or bile ducts)
• Renal colics (pain related to the kidneys or urinary tract, often from kidney stones)

Dosage and Administration:

Adults:

• Oral (Tablets): Take 1 to 2 tablets, three times daily, as needed for spasm relief.
• Injection (for acute cases): A healthcare professional may administer 1 to 2 ampoules via intramuscular (IM) or subcutaneous (SC) injection, 1-3 times daily. For acute stone colics, it can be given as 1 or 2 ampoules by slow intravenous (IV) injection.

Children (Oral – as an antispasmodic):

• Children over 6 years: 1/2 to 1 tablet, 1-2 times daily (equivalent to 40 mg 1-2 times daily).
• Children 1-6 years: 1/4 to 1/2 tablet, 1-2 times daily (equivalent to 20 mg 1-2 times daily).

Dortsil Tablet can be taken with or without food.

Important Precautions and Contraindications:

Do NOT use Dortsil Tablet if you have:

• Severe kidney, liver, or heart dysfunction.
• Porphyria (a rare genetic disorder).

Use with Caution if you have:

• Any existing kidney, liver, or heart problems.
• If you are pregnant or breastfeeding. (Excretion into breast milk is unknown.)

Drug Interactions:

• Dortsil may weaken the effect of levodopa (a medication for Parkinson’s disease).
• Concurrent use with analgesics (painkillers), antimuscarinics, or benzodiazepines may lead to an additive beneficial effect (increased spasm relief).

Possible Side Effects:

Common side effects include:

• Vertigo (dizziness)
• Nausea
• Vomiting
• Dry mouth

How it Works (Mechanism of Action):

Drotaverine, the active component of Dortsil, is an antispasmodic that directly acts on smooth muscles. It works by inhibiting phosphodiesterase-IV, which helps to correct imbalances in cyclic AMP and calcium at the site of the spasm, thereby relaxing the smooth muscle and relieving pain.