Clindacin gel

Description

Clindamycin phosphate in the gel formulation works by inhibiting bacterial protein synthesis. It binds to the 50S ribosomal subunit of susceptible bacteria, particularly Propionibacterium acnes (now often referred to as Cutibacterium acnes), which is a key bacterium implicated in the development of acne. By interfering with the formation of essential proteins, clindamycin stops the growth and multiplication of these bacteria on the skin, thus reducing their numbers. This action helps to decrease inflammation and prevent the formation of new acne lesions.

Clindacin gel typically comes as a clear, colorless gel containing clindamycin phosphate equivalent to 10 mg clindamycin per gram (1%). It is formulated with excipients like carbomer, methylparaben, polyethylene glycol, propylene glycol, and sodium hydroxide, which contribute to its gel consistency and stability.

When applied topically, a very small amount of clindamycin can be absorbed into the bloodstream, though systemic effects are rare with proper topical use. However, it’s important to note that oral and parenterally administered clindamycin have been associated with severe colitis (inflammation of the colon), including pseudomembranous colitis, which can be life-threatening. While this is less common with topical application, diarrhea, bloody diarrhea, and colitis have been reported, so patients with a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis should use it with caution or avoid it entirely.

For effective treatment, Clindacin gel should be applied as a thin film to the entire affected area, not just individual pimples, to prevent new breakouts. It’s usually applied once or twice daily, as directed by a healthcare professional, after cleansing and drying the skin. Consistent use over several weeks or even months is often necessary to see significant improvement, as topical clindamycin does not cure acne but helps to keep it under control. It is often used in combination with other acne treatments, such as benzoyl peroxide or retinoids, for enhanced efficacy and to reduce the risk of antibiotic resistance.

Side effects commonly include mild skin irritation, dryness, redness, peeling, or stinging at the application site. Patients should avoid contact with eyes, nose, mouth, or other mucous membranes.