Cefexim

Description

Cefexim Tablet (Cefixime)

Description: Cefexim Tablet contains Cefixime, a cephalosporin antibiotic.

Indications: Cefexim Tablet is used to treat various susceptible bacterial infections, including:

• Respiratory Tract Infections: Pneumonia, pharyngitis, sinusitis, tonsillitis, acute bronchitis, and acute exacerbations of chronic bronchitis.
• Ear Infections: Otitis media.
• Soft Tissue Infections.
• Typhoid Fever.
• Uncomplicated Gonococcal Urethritis.

Dosage and Administration:

Adults:

• Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated Urinary Tract Infections: 200 mg or 400 mg once daily as a single dose, or in two divided doses.
• Gonorrhea (Uncomplicated): 400 mg as a single dose.
• Typhoid Fever: 20 mg/kg body weight daily, divided into two doses. Treatment usually lasts 7 days but can be extended up to 14 days depending on the infection’s severity.

Children:

• General Dosing (for children weighing less than 50 kg): 8 mg/kg/day orally, given every 12–24 hours.
• For Convalescent Oral Therapy of Serious Infections: Up to 20 mg/kg/day.
• Powder for Suspension & DS Powder for Suspension (Specific Age-Based Dosing):
  • Children above 6 months: 8 mg/kg daily in 1-2 divided doses.
  • 6 months – 1 year: 75 mg daily.
  • 1 – 4 years: 100 mg daily.
  • 5 – 10 years: 200 mg daily.
• Typhoid Fever: 15-20 mg/kg/day orally, divided every 12 hours for 7-14 days; do not exceed 400 mg/day.
• Children < 6 months: Safety and efficacy have not been established.

Renal Impairment: A dose reduction is necessary.

• Creatinine Clearance (CrCl) < 20 mL/min: Maximum 200 mg daily.

Administration: Cefexim Tablet can be taken with or without food. Taking it with food or milk may help reduce gastrointestinal discomfort.

Contraindications:

• Hypersensitivity to cephalosporins.

Precautions:

• Patients with a history of allergy to penicillins.
• Pregnancy and lactation.
• Renal failure.
• Gastrointestinal (GI) disease.

Lactation: It’s unknown whether this drug is excreted in breast milk.

Interactions:

• Probenecid: May increase Cefixime concentrations.
• Anticoagulants: May potentially increase prothrombin time; close monitoring is advised.

Adverse Effects:

• Common (>10%): Diarrhea (16%).
• Frequency Not Defined (may include): Abdominal pain, candidiasis, dizziness, dyspepsia, elevated transaminases, eosinophilia, erythema multiforme, fever, flatulence, headache, increased blood urea nitrogen (BUN), increased creatinine, leukopenia, nausea, prolonged prothrombin time (PT), pruritus, pseudomembranous colitis, rash, serum sickness-like reaction, Stevens-Johnson syndrome, thrombocytopenia, urticaria, vaginitis, and vomiting.
• Potentially Fatal: Pseudomembranous colitis.

Mechanism of Action: Cefixime works by binding to penicillin-binding proteins (PBPs) in bacteria. This action inhibits the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall, which is essential for cell wall formation. By inhibiting biosynthesis and arresting cell wall assembly, Cefixime leads to bacterial cell death.

Note: Cefexim 200Mg Tablet is manufactured by Gracure Pharmaceuticals Ltd. Its generic name is Cefixime. Cefexim is available in Nepal. Please remember that this drug information is not a substitute for professional medical judgment and is not intended for diagnosis, medical advice, or treatment.