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Bestocef
Bestocef Syrup: Cefixime (100 mg/5 ml)
Bestocef Syrup, made by Curex Pharmaceuticals Pvt. Ltd., contains Cefixime, an antibiotic used to treat various bacterial infections like pneumonia, typhoid fever, sinusitis, tonsillitis, and bronchitis. It comes in a 60 ml bottle.
Dosing & Administration
- Adults: Typically 200-400 mg daily. For gonorrhea, it’s a single 400 mg dose. Typhoid fever is 20 mg/kg/day, usually for 7-14 days.
- Children: 8 mg/kg/day for most infections; 15-20 mg/kg/day for typhoid fever (not exceeding 400 mg/day). Not for infants under 6 months.
- Kidney Impairment: Dose reduction needed; maximum 200 mg daily if CrCl < 20 ml/min.
- Take with or without food; food or milk can lessen stomach upset.
Important Notes
- Do not use if allergic to cephalosporins.
- Use with caution if you have a history of penicillin allergy, kidney failure, or GI disease.
- Interactions: Can increase levels of probenecid and may dangerously increase bleeding risk with anticoagulants.
- Common Side Effect: Diarrhea (16%).
- Serious Side Effect: Pseudomembranous colitis.
Bestocef works by stopping bacteria from building their cell walls, leading to bacterial death. This information is for general knowledge and not a substitute for medical advi
Description
Bestocef Syrup (Cefixime 100 mg/5 ml)
Bestocef Syrup is an antibiotic manufactured by Curex Pharmaceuticals Pvt. Ltd. and is available in Nepal. Its active ingredient is Cefixime, a cephalosporin antibiotic used to treat a variety of bacterial infections.
Availability and Dosage Forms
Bestocef Syrup comes in a 60 ml pack size containing 100 mg of Cefixime per 5 ml.
Cefixime is also available in other forms:
- Tablets: 100 mg, 200 mg, and 400 mg
- Syrup: 50 mg/5 ml
Indications: What Bestocef Syrup is Used For
Bestocef Syrup is prescribed for various susceptible infections, including:
- Respiratory Tract Infections: Pneumonia, Pharyngitis, Sinusitis, Otitis media, Tonsillitis, Acute Bronchitis, and Acute Exacerbations of Chronic Bronchitis.
- Typhoid Fever
- Soft Tissue Infections
- Gonococcal Urethritis
Dosing Information
Always follow your doctor’s instructions regarding dosage.
Adult Dose
- Acute Bronchitis, Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated Urinary Tract Infections: 200 mg or 400 mg once daily, or in two divided doses.
- Gonorrhea: A single 400 mg dose.
- Typhoid Fever: 20 mg/kg body weight daily, divided into two doses. The usual treatment duration is 7 days, which may be extended up to 14 days based on the infection’s severity.
Child Dose
- For children weighing less than 50 kg: 8 mg/kg/day, given every 12 to 24 hours.
- For convalescent oral therapy of serious infections: Up to 20 mg/kg/day.
- Powder for Suspension & DS Powder for Suspension:
- Children above 6 months: 8 mg/kg daily in 1-2 divided doses.
- 6 months to 1 year: 75 mg daily.
- 1-4 years: 100 mg daily.
- 5-10 years: 200 mg daily.
- Typhoid Fever (children): 15-20 mg/kg/day orally, divided every 12 hours for 7-14 days. Do not exceed 400 mg/day.
- Note: Safety and efficacy have not been established for children under 6 months of age.
Renal Impairment (Kidney Issues)
Dose reduction is necessary for individuals with kidney impairment. If your Creatinine Clearance (CrCl) is less than 20 ml/min, the maximum daily dose should be 200 mg.
Administration
Bestocef Syrup can be taken with or without food. Taking it with food or milk may help reduce gastrointestinal discomfort.
Important Considerations
Contraindications
Do not take Bestocef Syrup if you have a known hypersensitivity to cephalosporin antibiotics.
Precautions
Inform your doctor if you have:
- A history of allergy to penicillins.
- Kidney failure.
- Gastrointestinal disease.
Pregnancy and Lactation
- Pregnancy: Use with caution and only if clearly needed.
- Lactation: It’s unknown if Cefixime is excreted in breast milk. Consult your doctor before using if you are breastfeeding.
Drug Interactions
- Probenecid: May increase the concentration of Cefixime in the body.
- Anticoagulants (blood thinners): Cefixime may potentially increase prothrombin time (PT), which could be fatal. Close monitoring is required.
Possible Side Effects
The most common side effect of Cefixime is diarrhea (16%).
Other reported side effects include:
- Abdominal pain
- Candidiasis
- Dizziness
- Dyspepsia
- Elevated transaminases
- Eosinophilia
- Erythema multiforme
- Fever
- Flatulence
- Headache
- Increased blood urea nitrogen (BUN)
- Increased creatinine
- Leukopenia
- Nausea
- Prolonged prothrombin time (PT)
- Pruritus
- Rash
- Serum sickness-like reaction
- Stevens-Johnson syndrome
- Thrombocytopenia
- Urticaria
- Vaginitis
- Vomiting
Potentially Fatal Side Effect: Pseudomembranous colitis. Seek immediate medical attention if you experience severe diarrhea, abdominal pain, or fever.
Mechanism of Action
Cefixime works by binding to penicillin-binding proteins (PBPs) in bacteria. This action inhibits the final step of peptidoglycan synthesis, which is crucial for bacterial cell wall formation. By disrupting cell wall assembly, Cefixime leads to the death of the bacterial cells.
Disclaimer: The information provided here about Bestocef Syrup is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.
Additional information
| form | Oral Tablets |
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