Anadol INJ 2ML

Description

Anadol INJ 2ML Injection: Key Information

Anadol INJ 2ML Injection is a medication containing Tramadol Hydrochloride 100mg. It is manufactured by Square Pharmaceuticals Ltd. and is available in a 1’s pack for a retail price of NPR 49.50.

Other Available Forms

Tramadol Hydrochloride is also available as:

• 50mg Capsules
• 50 mg/ml IM/IV Injection

Uses (Indications)

Anadol INJ 2ML Injection is primarily used for:

• Moderate to severe pain
• Postoperative pain

Dosage Information

Important Note: Always follow your doctor’s instructions for dosage. This information is for general understanding only.

Adult Dosing

• Oral (by mouth) for Moderate to Severe Pain:
  • Immediate Release:
    • Chronic Pain: Start with 25 mg every morning, increasing by 25-50 mg daily every 3 days. Doses can be taken as 50-100 mg every 4-6 hours as needed, but do not exceed 400 mg per day.
    • Acute Pain: Take 50-100 mg every 4-6 hours as needed, not to exceed 400 mg per day.
  • Extended Release: Start with 100 mg once daily, increasing by 100 mg daily every 5 days. Do not exceed 300 mg per day.
• Parenteral (IM/IV Injection) for Moderate to Severe Pain:
  • Administer 50-100 mg every 4-6 hours over 2-3 minutes.
• Parenteral (IM/IV Injection) for Postoperative Pain:
  • Initially, 100 mg, followed by 50 mg every 10-20 minutes if necessary, up to a total of 250 mg in the first hour (including the initial dose). Thereafter, 50-100 mg every 4-6 hours, up to a total daily dose of 600 mg.

Special Populations

• Elderly (over 75 years): The dosing interval may need to be increased.
• Hepatic (Liver) Impairment:
  • Severe Impairment: For immediate release, 50 mg every 12 hours. Extended release is not recommended.

Child Dosing

• Moderate to Severe Pain (Immediate Release):
  • Under 17 years: Safety and efficacy have not been established.
  • Over 17 years (Acute): 50-100 mg every 4-6 hours as needed, not to exceed 400 mg per day.
  • Over 17 years (Chronic): Start with 25 mg every morning, increasing by 25-50 mg daily every 3 days in separate doses up to 50-100 mg every 4-6 hours as needed. Do not exceed 400 mg per day.
• Extended Release:
  • Under 18 years: Safety and efficacy have not been established.

Renal (Kidney) Impairment

Administration

Anadol INJ 2ML Injection can be taken with or without food.

Contraindications (Who should NOT use this medication)

Do not use Anadol INJ 2ML Injection if you have:

• Suicidal tendencies
• Acute alcoholism
• Head injuries
• Raised intracranial pressure
• Severe renal impairment
• Are lactating (breastfeeding)

Precautions (Use with caution)

Use with caution if you have:

• Emotional disturbance or depression
• A history of epilepsy or risk of seizures
• A head injury
• Increased intracranial pressure
• Renal (kidney) or hepatic (liver) impairment
• Are elderly
• Are pregnant or lactating

Patient Counseling: This medication may impair your ability to drive or operate machinery.

Monitoring Parameters: Your doctor may monitor your pain relief, respiratory rate, blood pressure, pulse rate, and signs of tolerance, abuse, or suicidal ideation.

Pregnancy and Lactation

• Lactation: The drug is excreted in breast milk at high concentrations and is not recommended during breastfeeding.

Drug Interactions

Taking Anadol INJ 2ML Injection with certain other medications can increase the risk of side effects:

• Increased risk of convulsions or serotonin syndrome: When taken with SSRIs, SNRIs, TCAs, and other seizure-threshold-lowering drugs (e.g., bupropion, mirtazapine, tetrahydrocannabinol).
• Decreased serum concentrations of Anadol: When taken with carbamazepine.
• May potentiate the antidepressant effect of norepinephrine, 5-HT agonists, or lithium.
• Increased INR and ecchymoses: When taken with coumarin derivatives (e.g., warfarin).

Potentially Fatal Interactions:

• Increased risk of seizure and serotonin syndrome with MAOIs.

Possible Side Effects

Common side effects of Tramadol Hydrochloride include:

>10% (Very Common):

• Constipation (24-46%)
• Nausea (24-40%)
• Dizziness (10-33%)
• Vertigo (26-33%)
• Headache (18-32%)
• Somnolence (7-25%)
• Vomiting (9-17%)
• Agitation (7-14%)
• Anxiety (7-14%)
• Emotional lability (7-14%)
• Euphoria (7-14%)
• Hallucinations (7-14%)
• Nervousness (7-14%)
• Spasticity (7-14%)
• Dyspepsia (5-13%)
• Asthenia (6-12%)
• Pruritus (8-11%)

1-10% (Common):

• Diarrhea (5-10%)
• Dry mouth (5-10%)
• Sweating (6-9%)
• Hypertonia (1-5%)
• Malaise (1-5%)
• Menopausal symptoms (1-5%)
• Rash (1-5%)
• Urinary frequency (1-5%)
• Urinary retention (1-5%)
• Vasodilation (1-5%)
• Visual disturbance (1-5%)

<1% (Less Common):

• Abnormal gait, Amnesia, Cognitive dysfunction, Depression, Difficulty in concentration, Dysphoria, Dysuria, Fatigue, Hallucinations, Menstrual disorder, Motor system weakness, Orthostatic hypotension, Paresthesia, Seizures, Suicidal tendencies, Syncope, Tachycardia, Tremor

Frequency Not Defined:

• Abnormal electrocardiogram (ECG), Angioedema, Bronchospasm, Flushing, Hypertension, Hypotension, Myocardial ischemia, Palpitation, Urticaria, Withdrawal syndrome

Potentially Fatal Side Effect:

• Respiratory depression

How it Works (Mechanism of Action)

Tramadol works by inhibiting the reuptake of norepinephrine and serotonin, and by enhancing serotonin release. It also alters the perception and response to pain by binding to mu-opiate receptors in the central nervous system (CNS).

Disclaimer

This information about Anadol INJ 2ML Injection from Farmaco Nepal drug index is for general information only and is not intended for diagnosis, medical advice, or treatment. It is not a substitute for professional medical judgment. Always consult with a healthcare professional for any health concerns or before making any decisions related to your health or treatment.