Altramox

Description

Altramox Drop (Amoxicillin)

Indications:

Altramox Drop is used to treat a wide range of bacterial infections, including:

• Sore throat (Pharyngitis)
• Ear infections (Acute otitis media)
• Sinus infections (Acute bacterial sinusitis)
• Heart valve infections (Endocarditis)
• Anthrax
• Certain sexually transmitted infections like Chlamydial cervicitis and Chlamydial urethritis
• Lyme disease
• Dental abscesses
• Salmonella infections (Salmonellosis)
• Typhoid fever
• Uncomplicated gonorrhea
• Infections affecting the lower respiratory tract, skin and skin structures, genitourinary tract, ear, nose, and throat.

Dosage and Administration:

Adults:

• For most susceptible infections (by mouth): 250-500 mg every 8 hours.
• For uncomplicated gonorrhea (by mouth, with probenecid): A single dose of 3 grams.
• For dental abscesses (by mouth): 3 grams initially, then repeat once 8 hours later.
• For uncomplicated acute urinary tract infections (UTI) (by mouth): 3 grams initially, then repeat once 10-12 hours later.
• For endocarditis prevention (prophylaxis) before dental procedures (by mouth): 2 or 3 grams as a single dose, 1 hour before the procedure.
• For severe or recurrent respiratory tract infections (by mouth): 3 grams twice daily.
• For H. pylori infection (by mouth): 500 mg three times a day, typically in combination with metronidazole or clarithromycin, and a bismuth compound or an acid-reducing medication.
• For susceptible infections (by injection – IV/IM): 500 mg every 8 hours.
• For Listerial meningitis (by injection – IV, with other antibiotics): 2 grams every 4 hours for 10-14 days.

Children (by mouth):

• Standard dose: 40–45 mg per kg of body weight per day, divided into doses given every 8-12 hours.
• High dose: 80–90 mg per kg of body weight per day, with a maximum of 4 grams per day, divided into doses given every 12 hours.
• For penicillin-resistant S. pneumoniae otitis media: 150 mg per kg of body weight per day, divided into doses given every 8 hours.

Renal Impairment (Kidney Problems):

• Patients on hemodialysis: Should receive 250-500 mg every 24 hours, plus an additional dose during and after each dialysis session.
• Creatinine Clearance (CrCl) 10-30 ml/min: 250-500 mg every 12 hours.
• Creatinine Clearance (CrCl) <10 ml/min: 250-500 mg every 24 hours.

Administration:

Altramox can be taken with or without food. Taking it with meals may improve absorption and help reduce stomach discomfort.

Contraindications (When Not to Use):

• Do not use if you have a hypersensitivity (allergic reaction) to amoxicillin or any other penicillin.

Precautions (Use with Caution):

• If you have kidney or liver disease.
• If you are pregnant or breastfeeding. Amoxicillin is excreted in breast milk, so caution is advised.
• If you have infectious mononucleosis, as there’s an increased risk of rash.

Interactions with Other Medications:

• May reduce the effectiveness of oral contraceptives (birth control pills).
• May increase the effect of anticoagulants (blood thinners).
• Increased risk of allergic reactions when taken with allopurinol.
• Increased and prolonged blood levels of amoxicillin when taken with probenecid.
• Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effect of amoxicillin.

Adverse Effects (Side Effects):

• Common: Hyperactivity, agitation, insomnia, dizziness; skin rashes (maculopapular rash, exfoliative dermatitis, urticaria, hypersensitivity vasculitis); diarrhea, nausea, vomiting; changes in blood counts like anemia, thrombocytopenia (low platelets), leucopenia (low white blood cells), and agranulocytosis.
• Potentially Fatal: Neuromuscular hypersensitivity (severe allergic reaction affecting nerves and muscles); pseudomembranous colitis (a severe type of colon inflammation).

Mechanism of Action:

Amoxicillin works by targeting bacteria’s cell walls. It binds to specific proteins (penicillin-binding proteins or PBPs) that are crucial for building the bacterial cell wall. By doing so, it prevents the final step of cell wall synthesis, leading to the bacterial cells breaking apart (lysis) and dying.

Note:

Altramox 100mg Drop is manufactured by Alliance Pharmaceuticals Pvt. Ltd. Its generic name is Amoxicillin, and it is available in Nepal.

Important Disclaimer: The information provided here about Altramox Drop is for general informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.