Lanzol

Description

Lanzol Capsule

Lanzol Capsule, with the generic name Lansoprazole, is a proton pump inhibitor (PPI) manufactured by Cipla Ltd. It’s available in Nepal.

Uses (Indications)

Lanzol Capsule is used to treat conditions caused by excessive stomach acid, including:

• Peptic ulcer (duodenal and gastric ulcers)
• H. pylori infection (in combination therapy)
• Gastro-oesophageal reflux disease (GERD)
• Hypersecretory conditions (e.g., Zollinger-Ellison syndrome)
• Acid-related dyspepsia (indigestion)
• NSAID-induced ulcers (both treatment and prevention)
• Erosive oesophagitis (inflammation of the esophagus due to acid reflux)

How It Works (Mechanism of Action)

Lansoprazole is a substituted benzimidazole, also known as a PPI. It works by blocking the final step of acid secretion in the stomach. It does this by inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells, effectively reducing both basal (resting) and stimulated acid production.

Dosage Information

Administration: Lanzol Capsule should be taken on an empty stomach, preferably before meals.

Adults:

• Peptic Ulcer:
  • Duodenal ulcer: 30 mg once daily in the morning for up to 4 weeks.
  • Gastric ulcer: 30 mg once daily in the morning for up to 8 weeks.
  • Maintenance: 15 mg once daily.
• Zollinger-Ellison Syndrome: Initially, 60 mg once daily in the morning. Doses greater than 120 mg daily should be given in two divided doses. Adjust as required based on response.
• Acid-Related Dyspepsia: 15-30 mg once daily in the morning for 2-4 weeks.
• Gastro-oesophageal Reflux Disease (GERD): 15-30 mg once daily in the morning for 4-8 weeks.
  • Maintenance: 15-30 mg once daily, adjusted according to response.
• Prophylaxis of NSAID-Induced Ulcers: 15-30 mg once daily in the morning.
• H. pylori Infection (Triple Therapy – 1 week): 30 mg twice daily combined with:
  • Clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily, OR
  • Clarithromycin 250 mg twice daily and metronidazole 400 mg twice daily.
• Erosive Oesophagitis: 30 mg once daily in the morning for up to 8 weeks. An additional 8 weeks may be needed if not healed.
  • Maintenance: 15 mg once daily.
• NSAID-Associated Ulceration (Treatment): 30 mg once daily in the morning for 4-8 weeks.
• Elderly: No dosage adjustment is typically needed.
• Severe Hepatic Impairment: Maximum daily dose is 30 mg.

Children:

• Gastro-oesophageal Reflux Disease (GERD) & Erosive Oesophagitis:
  • 1-11 years:
    • Weight < 30 kg: 15 mg once daily in the morning for up to 12 weeks.
    • Weight > 30 kg: 30 mg once daily in the morning for up to 12 weeks.
    • Doses may be increased up to 30 mg twice daily if the patient remains symptomatic after two or more weeks of treatment.
  • 12-17 years: 15 mg once daily for up to 8 weeks (for GERD); 30 mg once daily for up to 8 weeks (for erosive oesophagitis).
• Renal Impairment: No dosage adjustment is typically needed.

Important Considerations

Do Not Use If You Have (Contraindications):

• Hypersensitivity (allergy) to Lansoprazole or any of its ingredients.

Use with Caution If You Have (Precautions):

• Hepatic impairment (liver disease).
• Gastric malignancy (stomach cancer) should be ruled out before starting treatment, as Lanzol can mask symptoms.
• Pregnancy and lactation: Use with caution. It’s not known if Lanzol is distributed into breast milk; nursing is generally not recommended.

Potential Drug Interactions

• Increased Risk:
  • Hypomagnesaemia: Increased risk with diuretics and digoxin.
  • Cilostazol and Methotrexate: May increase their plasma concentrations.
• Decreased Effectiveness:
  • Erlotinib, Dasatinib, Lapatinib: May decrease their plasma concentrations.
  • Itraconazole and Ketoconazole: May decrease their bioavailability.
  • Antacids and Sucralfate: May reduce the bioavailability of Lanzol; take Lanzol at least 30 minutes before these medications.
• Potentially Fatal Interactions: May significantly decrease serum levels and pharmacological effects of rilpivirine and atazanavir.

Possible Side Effects (Adverse Effects)

Common (1-10%):

• Headache (3-7%)
• Diarrhea (1-5%)
• Constipation (1-5%)
• Nausea (1-3%)
• Abdominal pain (1-3%)

Less Common (<1%):

• Anxiety
• Angina (chest pain)
• Palpitations (fast heartbeats)
• Syncope (fainting)
• Edema (swelling)
• Anorexia (loss of appetite)
• Dry mouth
• Tenesmus (straining during bowel movements)
• Flatulence (gas)
• Melena (dark, tarry stools)
• Myalgia (muscle pain)
• Tinnitus (ringing in the ears)
• Allergic reaction

Disclaimer: This information about Lanzol Capsule is for general knowledge and informational purposes only, and does not constitute medical advice. It is not intended for diagnosis, treatment, or to be a substitute for the professional judgment of a healthcare provider. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatmen