Vomistop

Description

Vomistop (Domperidone) 10mg Tablet: Patient Information

Description

Vomistop is a medication containing the active ingredient Domperidone. It is manufactured by Curex Pharmaceuticals Pvt. Ltd. and is available in Nepal. Vomistop works by blocking peripheral dopamine receptors, which helps to regulate the movement of the esophagus and stomach. This action increases the downward contractions of the esophagus, improves the coordination between the stomach and the small intestine, and helps to empty the stomach more efficiently.

This information is for educational purposes and should not be used as a substitute for professional medical advice.

Uses

Vomistop tablets are indicated for the relief of the following conditions:

• Nausea and vomiting
• Gastritis (inflammation of the stomach lining)
• Gastroparesis (delayed stomach emptying)
• Non-ulcer dyspepsia (indigestion not caused by an ulcer)
• Migraine-related nausea
• To promote lactation

Dosage and Administration

It is important to take Vomistop 15-30 minutes before meals on an empty stomach.

Adult Dosage:

• For Nausea and Vomiting:
  • Oral: 10-20 mg every 4-8 hours. The maximum daily dose is 80 mg.
  • Rectal: 60 mg twice daily.
• For Non-Ulcer Dyspepsia:
  • Oral: 10 mg taken 3-4 times a day. The dosage may be increased to a maximum of 20 mg, 3-4 times daily. The final dose of the day should be taken at bedtime.
• For Migraine:
  • Oral: 20 mg every 4 hours. Do not exceed 4 doses in a 24-hour period.

Pediatric Dosage:

• Oral: 0.2 – 0.4 mg per kilogram of body weight, given every 4-8 hours.
• Rectal:
  • Children under 12 years (weighing more than 15 kg): 30 mg twice daily.
  • Children over 12 years (weighing more than 35 kg): 60 mg twice daily.

Special Populations:

• Elderly: No dose adjustment is necessary.
• Liver Impairment: No dose adjustment is necessary.
• Kidney Impairment:
  • Mild to Moderate: No dose adjustment is needed.
  • Severe: The frequency of dosing should be reduced to once or twice daily for long-term treatment.

Important Safety Information

Contraindications (Do not take Vomistop if you have):

• An allergy or hypersensitivity to Domperidone.
• Gastrointestinal bleeding, blockage, or a tear in the intestinal wall.
• A prolactin-releasing pituitary tumor.
• This medication should not be used for chronic treatment or for the routine prevention of nausea and vomiting after surgery.

Precautions:

Consult your doctor before taking Vomistop if you have any of the following conditions:

• Pheochromocytoma (a type of tumor on the adrenal glands).
• Kidney or liver problems.
• A history of heart rhythm problems or low potassium levels, especially when the medication is given intravenously.
• Are pregnant or breastfeeding.
• Use in children under 2 years of age and the elderly should be done with caution.

Pregnancy and Lactation:

Please consult your healthcare provider before using Vomistop during pregnancy or while breastfeeding.

Drug Interactions:

• Vomistop may interfere with the effects of bromocriptine.
• The effectiveness of Vomistop may be reduced by opioid pain relievers and antimuscarinic drugs.
• Potentially Serious Interaction: Taking Vomistop with strong CYP3A4 inhibitors (such as ketoconazole, erythromycin, or ritonavir) can increase the level of Domperidone in the blood, which may lead to a higher risk of a serious heart rhythm problem known as QT prolongation.

Possible Side Effects:

Common Side Effects:

• Drowsiness
• Constipation or diarrhea
• Fatigue (lassitude)
• Decreased sex drive
• Skin rash or itching
• Involuntary muscle movements (extrapyramidal reactions)
• Milk production in men or women who are not breastfeeding (galactorrhea)
• Breast enlargement in men (gynecomastia)

Potentially Serious Side Effects:

• Seizures
• Irregular heartbeats (arrhythmias) and, in rare cases, cardiac arrest. This risk is higher in individuals with existing cardiovascular disease, low potassium levels, or those undergoing cancer chemotherapy.
• A hypertensive crisis (a sudden, severe increase in blood pressure) may occur in patients with pheochromocytoma.

If you experience any severe or concerning side effects, seek immediate medical attention.