Valparin Chrono
Valparin Chrono Tablet is a medication primarily used to treat various types of epilepsy and bipolar disorder. It can also be used for migraine prevention.
Valproate, the active ingredient in Valparin Chrono, is a carboxylic acid anticonvulsant. Its exact mechanism of action isn’t fully understood, but it’s believed to increase levels of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter that helps calm nerve activity, which can reduce seizures.
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Valparin Chrono Tablet: Uses, Dosage, and Important Information
Valparin Chrono Tablet is a medication primarily used to treat various types of epilepsy and bipolar disorder. It can also be used for migraine prevention.
What Valparin Chrono Tablet is Used For:
- Epilepsy:
- Partial seizures (complex, simple)
- Absence seizures (petit mal)
- Generalized tonic-clonic seizures (grand mal)
- Myoclonic seizures
- Atonic seizures
- Mixed seizures (including those with absence seizures)
- Migraine: For the prevention of migraine headaches (not for acute treatment).
- Bipolar Disorder: To treat manic episodes associated with bipolar disorder.
Please note: While listed in the original text, there is no strong evidence for the use of Valparin Chrono for Anxiety disorder, Posttraumatic stress disorder, Febrile convulsion, Anorexia nervosa, or Panic attacks.
Dosage Information
The dosage of Valparin Chrono Tablet varies depending on the condition being treated and the patient’s age and response. Always follow your doctor’s instructions.
Adult Dosing
- Complex Partial Seizures (Monotherapy or Adjunctive Therapy):
- Initial: 10-15 mg/kg per day by mouth.
- Increase: By 5-10 mg/kg per day weekly, as directed by your doctor.
- Maximum: Up to 60 mg/kg per day.
- Simple & Complex Absence Seizures (Monotherapy or Adjunctive Therapy):
- Initial: 15 mg/kg per day by mouth, divided into 2 doses (every 6-12 hours).
- Increase: By 5-10 mg/kg per day weekly, as directed by your doctor.
- Maximum: Up to 60 mg/kg per day.
- Migraine Prophylaxis:
- Initial: 250 mg by mouth twice daily (every 12 hours).
- Adjustment: Your doctor will adjust the dose based on your response.
- Maximum: 1000 mg per day.
- Bipolar Mania:
- Initial: 750 mg per day by mouth, in divided doses.
- Adjustment: Your doctor will adjust the dose rapidly to achieve the desired effect.
- Maximum: Not to exceed 60 mg/kg per day.
Child Dosing
- Children under 10 years: The safety and effectiveness of Valparin Chrono Tablet have not been established.
- Complex Partial Seizures (>10 years): Same as adult dosage (10-15 mg/kg per day initially, increasing up to 60 mg/kg per day).
- Simple & Complex Absence Seizures (>10 years): 250 mg by mouth twice daily (every 12 hours); adjust dose based on clinical response up to 1000 mg per day.
Special Populations
- Hepatic Impairment (Liver Problems): Lower doses are administered. Valparin Chrono is contraindicated in severe hepatic impairment.
- Renal Impairment (Kidney Problems): No dosage adjustment is typically necessary.
Important Considerations & Precautions
How to Take
Valparin Chrono Tablet can be taken with meals to help reduce gastrointestinal side effects. Starting with a low dose and using enteric-coated formulations can also help.
When Not to Take (Contraindications)
Do not take Valparin Chrono Tablet if you have:
- A pre-existing or family history of hepatic dysfunction (liver problems).
- Active liver disease.
- Porphyria.
- Mitochondrial or urea cycle disorders.
- Severe hepatic impairment.
- Are pregnant.
Warnings & Precautions
- Liver Toxicity: There’s an increased risk of liver toxicity, especially in children under 2 years old, or those with congenital metabolic disorders, organic brain disease, or severe seizure disorders.
- Monitoring: Regular monitoring of liver function tests (especially during the first 6 months), blood cell counts (including platelets), bleeding time, and coagulation tests is crucial.
- Symptoms to Watch For: Seek immediate medical advice if you experience signs of pancreatitis (e.g., abdominal pain, nausea, vomiting, anorexia) or signs of blood/liver toxicity.
- Behavioral Changes: Monitor for unusual behavior, including suicidal thoughts or actions, during and after treatment.
- Hyperammonemia: If unexplained lethargy, vomiting, or changes in mental status occur, suspect hyperammonemic encephalopathy and measure ammonia levels.
- Bone Health: Patients who are immobilized or have insufficient sun exposure or calcium intake should consider vitamin supplementation.
- Withdrawal: Do not stop taking Valparin Chrono abruptly. Withdrawal should be gradual and supervised by a doctor.
- Pregnancy & Breastfeeding: Valparin Chrono is contraindicated in pregnancy. Discuss the risks and benefits with your doctor if you are breastfeeding.
Potential Drug Interactions
Valparin Chrono can interact with many other medications. Be sure to tell your doctor about all medicines you are taking, including over-the-counter drugs and herbal supplements.
Some key interactions include:
- Increased toxicity with: Bupropion.
- Increased risk of convulsions with: Mefloquine.
- Increased risk of carnitine deficiency with: Pivmecillinam and pivampicillin.
- Carbamazepine: Can lead to decreased valproic acid levels and increased carbamazepine toxicity. Concurrent use is not recommended.
- Decreased Valproic Acid levels with: Carbapenems (potentially fatal interaction, avoid concurrent use), rifampicin, phenytoin, phenobarbital (or primidone), and certain antineoplastic drugs.
- Increased Valproic Acid levels with: Felbamate and aspirin (avoid concurrent salicylates in children under 3 due to hepatotoxicity risk).
- Increased levels of other drugs with Valproate: Phenobarbital, nimodipine, nifedipine, lamotrigine, zidovudine, amitriptyline, nortriptyline, and benzodiazepines.
- Decreased levels of other drugs with Valproate: Tiagabine and clozapine.
- Increased risk of absence status with: Clonazepam.
- Increased risk of hyperammonemia with: Topiramate.
- Ethanol (alcohol): Avoid concurrent use as it may increase CNS depression.
Possible Side Effects
Like all medications, Valparin Chrono Tablet can cause side effects. Many are mild and resolve on their own, but some can be serious.
Very Common (more than 10% of users):
- Nausea
- Headache
- Increased bleeding time
- Thrombocytopenia (low platelet count)
- Tremor
- Alopecia (hair loss)
- Asthenia (weakness)
- Infection
- Somnolence (drowsiness)
- Amblyopia (lazy eye)
- Diarrhea
- Diplopia (double vision)
- Dizziness
- Dyspepsia (indigestion)
- Nystagmus (involuntary eye movements)
- Tinnitus (ringing in the ears)
- Vomiting
Common (1-10% of users):
- Ataxia (impaired coordination)
- Increased appetite
- Rash
- Abdominal pain
- Back pain
- Mood changes
- Anxiety
- Confusion
- Abnormal gait (walking)
- Paresthesia (numbness/tingling)
- Hallucinations
- Catatonia
- Dysarthria (difficulty speaking)
- Tardive dyskinesia (involuntary movements)
- Vertigo
- Irregular menstrual periods
- Weight gain
Frequency Not Defined (may occur, but exact frequency is unknown):
- Anorexia (loss of appetite)
- Acute pancreatitis (can be life-threatening)
- Hepatic toxicity (liver damage)
- Hyperammonemia (high ammonia levels)
- Weight loss
- Fractures
- Osteoporosis (bone thinning)
- Osteopenia (reduced bone density)
- Cerebral pseudoatrophy (apparent brain shrinkage)
How Valparin Chrono Works (Mechanism of Action)
Valproate, the active ingredient in Valparin Chrono, is a carboxylic acid anticonvulsant. Its exact mechanism of action isn’t fully understood, but it’s believed to increase levels of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter that helps calm nerve activity, which can reduce seizures.
General Information
- Valparin Chrono 133mg Tablet is manufactured by Sanofi India Ltd.
- Its generic name is Sodium Valproate (valproic acid).
- Valparin Chrono is available in Nepal.
Disclaimer: This information is for general knowledge only and is not intended for diagnosis, medical advice, or treatment. It is not a substitute for professional medical judgment. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.
Additional information
form | Oral Tablets |
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