₨ NPR
Umetac
Umetac 50mg Injection, manufactured by Umedica, contains the active ingredient Ranitidine. It’s available in Nepal and is primarily used to treat conditions caused by excessive stomach acid. A 2ml pack size retails for 10.00 NPR.
Key Uses (Indications)
Umetac Injection is prescribed for:
- Dyspepsia (indigestion)
- H. pylori infection (in combination with other medications)
- Benign gastric and duodenal ulceration
- Gastro-oesophageal reflux disease (GERD)
- Acid aspiration during general anesthesia (prophylaxis)
₨10.00
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Contraindications
- Porphyria
Precautions
- Before starting treatment, your doctor should rule out the possibility of malignancy, as Ranitidine can mask symptoms and delay diagnosis of gastric cancer.
- Use with caution in patients with difficulty swallowing.
- Requires careful consideration in patients with renal and hepatic impairment.
- Pregnancy and lactation: Use with caution. The drug crosses into breast milk; consider discontinuing the drug or using an alternative.
Interactions
- Propantheline bromide can delay absorption and increase peak serum concentration of Ranitidine.
- Ranitidine minimally inhibits the metabolism of coumarin anticoagulants, theophylline, diazepam, and propanolol.
- May alter the absorption of pH-dependent drugs (e.g., ketoconazole, midazolam, glipizide).
- May reduce bioavailability when taken with antacids.
Possible Side Effects
Common (1-10%):
- Headache (3%)
Less Common (<1%):
- Abdominal pain, agitation, alopecia, confusion, constipation, diarrhea, dizziness, hypersensitivity reaction, nausea, vomiting.
Rare (Frequency Not Defined, but potentially serious):
- Anemia, necrotizing enterocolitis (in fetus or newborn), pancreatitis, thrombocytopenia, pancytopenia, agranulocytosis, acquired immune hemolytic anemia, arthralgia, myalgia.
Potentially Fatal:
- Anaphylaxis, severe hypersensitivity reactions.
Mechanism of Action
Ranitidine works by competitively blocking histamine at the H2-receptors located on the gastric parietal cells. This action inhibits the secretion of gastric acid. It does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion, or serum gastrin levels.
Other Brands of Ranitidine in Nepal
- Tablets:
- Tagon 150mg (Apex Pharmaceuticals Pvt. Ltd.)
- Acidin 150mg (S.R. Drug Laboratories Pvt. Ltd.)
- Aciloc 150mg (Cadila Pharmaceuticals Limited.)
- Aciloc 300mg (Cadila Pharmaceuticals Limited.)
- Injection:
- Aciloc (Cadila Pharmaceuticals Limited.)
Additional information
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