Triad 25mg

Description

Triad 25mg, containing Amitriptyline Hydrochloride, belongs to a class of medications called tricyclic antidepressants (TCAs). It works by affecting chemical messengers in the brain, specifically by inhibiting the reuptake of norepinephrine and serotonin in the central nervous system. This action helps to increase the levels of these neurotransmitters in the brain, which is believed to contribute to its therapeutic effects.

Amitriptyline 25mg has a sedative effect, which often leads to it being prescribed for evening or bedtime administration. It is well-absorbed orally, reaching peak plasma concentrations within a few hours. The medication undergoes significant metabolism in the liver.

Due to its mechanism of action, Amitriptyline can influence various bodily functions, leading to a range of potential side effects, including anticholinergic effects (e.g., dry mouth, blurred vision, constipation, urinary retention), cardiovascular effects (e.g., orthostatic hypotension, tachycardia, arrhythmias), and central nervous system effects (e.g., drowsiness, dizziness, confusion, tremors). It can also cause weight gain and affect sexual function.

Important Considerations:

• Not for sudden discontinuation: Amitriptyline therapy should not be interrupted abruptly, as this can lead to withdrawal symptoms (e.g., nausea, headache, tiredness). Dosage should be gradually reduced under medical supervision.
• Suicidal thoughts: Like other antidepressants, Amitriptyline can increase the risk of suicidal thoughts and behavior, especially in children, adolescents, and young adults. Close monitoring is essential for all patients, particularly at the beginning of treatment or after dose changes.
• Interactions: Amitriptyline interacts with numerous other medications, including monoamine oxidase inhibitors (MAOIs), CNS depressants, and certain heart medications. It’s crucial to inform your doctor about all other medications you are taking.
• Contraindications: It is contraindicated in individuals with hypersensitivity to TCAs, during the acute recovery phase of a myocardial infarction, and in conjunction with MAOIs. Caution is advised for patients with heart problems, liver disease, or conditions predisposing them to seizures.