Tretino 0.025

Description

Tretino 0.025 Cream is used to treat:

• Acne
• Mottled hyperpigmentation (uneven dark spots)
• Roughness and fine wrinkling of photodamaged skin (skin damaged by sun exposure)

How to Use

For Adults (Topical/Cutaneous Application):

• Acne vulgaris: Apply once daily, typically at bedtime, to the affected area after it has been cleansed to remove excess oiliness and dried. You may see a therapeutic response after 6-8 weeks.
• Mottled hyperpigmentation, roughness, and fine wrinkling of photodamaged skin: Apply a pea-sized amount onto the entire face once daily at night. A therapeutic response may be seen after 6 months.

For Children (Topical/Cutaneous Application):

• Acne Vulgaris:
  • Under 12 years: Safety and efficacy have not been established.
  • Over 12 years: Apply once daily, usually at bedtime, onto the affected area.

Important Precautions

• Do not use if you have a hypersensitivity to retinoids, or if the skin is eczematous (inflamed), sunburnt, or abraded (scraped/damaged).
• Avoid use during pregnancy or lactation.
• Avoid concomitant topical applications, especially keratolytic agents (products that promote peeling of the skin).
• Limit exposure to sunlight, UV light, and weather extremes (e.g., cold).
• Keep away from your eyes, mouth, corners of your nose, mucous membranes, or open wounds.
• If you experience severe local erythema (redness), oedema (swelling), blistering, or crusting, use less frequently or discontinue the application.
• Avoid medicated or drying soaps, abrasive soaps and cleansers, frequent washing, and harsh scrubbing.
• Do not use topical preparations with high concentrations of alcohol, menthol, spices, or lime.

Potential Side Effects

Common side effects of Tretinoin Topical include:

• Initial worsening of symptoms
• Skin irritation
• Stinging on application
• Oedema (swelling)
• Blistering
• Crusting of the skin
• Erythema (redness)
• Scaling
• Photosensitivity (increased sensitivity to light)
• Temporary hypo/hyperpigmentation (lighter or darker skin patches)

Drug Interactions

Tretinoin Topical can interact with other medications:

• It enhances percutaneous absorption of minoxidil.
• There’s an increased risk of fatal thrombotic complications with antifibrinolytic medications.
• Increased tretinoin concentrations can occur with azole antifungals.
• It enhances the peeling action of sulfur, resorcinol, benzoyl peroxide, and salicylic acid.
• There’s increased photosensitivity with photosensitizing medications (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines, and sulfonamides).
• Potentially Fatal: There is an increased risk of intracranial pressure with tetracyclines.