Tildom

Description

Tildom 10mg Tablet: An Overview

Tildom 10mg Tablet is a medication manufactured by Tablets India Limited. Its active ingredient is Domperidone.

This information is for general knowledge and should not replace professional medical advice. Always co`sult a healthcare provider for diagnosis, treatment, or any medical concerns.

Key Information

• Generic Name: Domperidone
• Strength: 10mg
• Pack Size: 100 tablets
• Retail Price: 4.76 NPR
• Availability: Available in Nepal

Uses (Indications)

Tildom Tablet (Domperidone) is primarily used to treat:

• Nausea and Vomiting
• Gastritis
• Gastroparesis (delayed stomach emptying)
• Non-ulcer Dyspepsia (indigestion not caused by ulcers)
• Migraine (for associated nausea and vomiting)
• Lactation (to promote milk production, though this is an off-label use and should be discussed with a doctor)

Dosage Information

Tildom should generally be taken on an empty stomach, about 15-30 minutes before meals.

Adult Dosing

• Nausea and Vomiting: 10-20 mg, taken 4-8 hourly. Do not exceed 80 mg per day.
  • Rectal Administration: 60 mg twice daily.
• Non-ulcer Dyspepsia: 10 mg, 3-4 times daily. Maximum of 20 mg, 3-4 times daily, with the last dose taken at bedtime.
• Migraine: 20 mg, every 4 hours. Do not exceed 4 doses within 24 hours.

Child Dosing

• Oral: 0.2 – 0.4 mg/kg, every 4 – 8 hours daily.
• Rectal:
  • Children under 12 years old weighing more than 15 kg: 30 mg twice daily.
  • Children over 12 years old weighing more than 35 kg: 60 mg twice daily.

Special Populations

• Elderly: No dosage adjustment is typically needed.
• Hepatic (Liver) Impairment: No dosage adjustment is typically needed.
• Renal (Kidney) Impairment:
  • Mild to moderate impairment: No dosage adjustment needed.
  • Severe impairment: Dosing should be reduced to 1-2 times daily with prolonged treatment.

Important Considerations

Contraindications (Who should NOT take Tildom)

Do not take Tildom if you have:

• Hypersensitivity (allergy) to Domperidone.
• Gastrointestinal hemorrhage, obstruction, or perforation.
• A prolactin-releasing pituitary hormone tumor.
• Chronic administration or routine prophylaxis for postoperative nausea and vomiting.

Precautions (Use with caution)

Discuss with your doctor before taking Tildom if you have:

• Phaeochromocytoma (a tumor of the adrenal gland).
• Children under 2 years old (use with extreme caution).
• Renal or hepatic impairment.
• A history of cardiac arrhythmias or hypokalemia, especially if administered intravenously (IV administration of Domperidone carries a higher risk of cardiac issues).
• Pregnancy or are breastfeeding.

Interactions with Other Medications

• May reduce the effectiveness of bromocriptine (used for high prolactin levels).
• Opioid analgesics and antimuscarinics may reduce Domperidone’s prokinetic (motility-enhancing) effect.
• Potentially Fatal Interaction: Concomitant use with potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir) can significantly increase Domperidone levels in the blood, increasing the risk of serious heart problems (QT prolongation).

Potential Side Effects

While generally well-tolerated, Domperidone can cause side effects, including:

• Drowsiness
• Extrapyramidal reactions (involuntary muscle movements)
• Galactorrhea (unexplained milk production)
• Gynecomastia (breast enlargement in males)
• Constipation or diarrhea
• Lassitude (lack of energy)
• Decreased libido
• Skin rash, itching

Potentially Fatal Side Effects (Rare but serious)

Seek immediate medical attention if you experience:

• Convulsions (seizures)
• Arrhythmias (irregular heartbeats) and cardiac arrest, especially in patients with pre-existing cardiovascular disease or hypokalemia.
• Dysrhythmias in patients with cardiovascular disease or hypokalemia.
• Hypertensive crisis in patients with phaeochromocytoma.

How Tildom Works (Mechanism of Action)

Domperidone works as a peripheral dopamine-receptor blocker. This means it primarily acts on dopamine receptors outside the brain. By doing so, it:

• Increases esophageal peristalsis (muscle contractions in the esophagus).
• Enhances gastroduodenal coordination (improves muscle coordination between the stomach and small intestine).
• Lowers esophageal sphincter pressure.
• Increases gastric motility and peristalsis (stomach muscle movement), which helps facilitate gastric emptying and decreases the time it takes for food to pass through the small bowel.