Tenof

Description

Tenof Tablet: Your Guide to Use

Tenof Tablet is an antiviral medication used to treat HIV-1 infection and chronic hepatitis B. For HIV-1, you’ll always use it with other anti-retroviral medications.

How to Use

You can take Tenof Tablet with or without food. It’s best to be consistent—always take it with food or always without—to keep the medication levels steady in your body.

Adult Dosing:

• Chronic Hepatitis B & HIV-1 Infection: Take 300 mg once daily.

Child Dosing:

• HIV-1 Infection:
  • Under 2 years: We don’t know the safety and effectiveness for this age group.
  • Over 2 years: Give 8 mg per kg of body weight by mouth once daily. Don’t exceed 300 mg per day.
• Hepatitis B Infection:
  • Under 12 years: We don’t know the safety and effectiveness for this age group.
  • Over 12 years and under 35 kg: We don’t know the safety and effectiveness for this age group.
  • Over 12 years and over 35 kg: Give 300 mg by mouth once daily.

Special Dosing for Kidney Impairment

If you have kidney problems, your doctor will adjust your dose.

HIV Infection & Chronic Hepatitis B with Kidney Impairment:

Important Considerations

Do Not Use If:

• You have a known hypersensitivity or allergy to Tenofovir or any ingredient in Tenof Tablet.

Precautions:

• Liver Health: Use caution if you have liver enlargement (hepatomegaly) or other risk factors for liver disease. Your liver function will be monitored for several months after you stop the medication.
• Kidney Impairment: Be cautious if you have kidney problems. Your kidney function and serum phosphate levels will be checked before you start therapy, weekly for the first week, and then every 3 months.
• HIV Status: If you have hepatitis B, your doctor will determine your HIV status before starting treatment with Tenof Tablet.
• Pregnancy: If you are pregnant, discuss the risks and benefits with your doctor.
• Dizziness: This medication might cause dizziness. Do not drive or operate machinery if you feel dizzy.
• Breastfeeding: HIV-positive women should not breastfeed to prevent the risk of transmitting HIV to the baby.

Interactions:

It’s crucial to tell your doctor about all medicines you’re taking, including over-the-counter drugs and herbal supplements.

• Atazanavir: Tenofovir can decrease atazanavir concentrations unless ritonavir is also given.
• Drugs Eliminated by Active Tubular Secretion: Taking Tenof with drugs eliminated this way may increase the concentration of Tenof or the co-administered drug in your blood.
• Potentially Fatal Interactions:
  • Nephrotoxic Agents: Avoid recent or concurrent use with medications that can harm the kidneys (e.g., aminoglycosides, amphotericin B, foscarnet, ganciclovir, pentamidine, vancomycin, cidofovir, or interleukin-2). If it’s unavoidable, your kidney function must be monitored weekly.
  • Didanosine: Avoid using Tenof with didanosine, as it can increase didanosine levels. This can lead to a higher risk of pancreatitis (inflammation of the pancreas) and peripheral neuropathy (nerve damage), along with a high rate of treatment failure.

Potential Side Effects

While taking Tenof Tablet, you might experience some side effects.

Very Common (More than 10%):

• Weakness/lack of energy (asthenia) (11%)
• Diarrhea (16%)
• Nausea (11%)
• Pain (12%)

Common (1-10%):

• Loss of appetite (anorexia)
• Depression
• Muscle pain (myalgia)
• Nerve problems (peripheral neuropathy)
• Indigestion (dyspepsia)
• Rash
• Headache
• Vomiting
• Flatulence
• Abdominal pain
• Low white blood cell count (neutropenia)
• Increased liver enzymes (transaminases)

How It Works

Tenofovir disoproxil fumarate is a “prodrug.” This means your body converts it into the active drug, tenofovir. Tenofovir is a nucleotide reverse transcriptase inhibitor. Once active, it blocks the activity of HIV-1 reverse transcriptase, an enzyme essential for HIV to multiply. It also inhibits the activity of the hepatitis B virus polymerase. By blocking these enzymes, Tenof helps stop the viruses from replicating.

Additional Information

Tenof 300mg Tablet is manufactured by Magnus Pharma Pvt. Ltd. Its generic name is Tenofovir Disoproxil Fumarate, and it is available in Nepal.

Please Note: This information is not intended to provide medical advice or diagnosis, and it should not replace the professional judgment of a healthcare provider.