Synogel Syrup

Description

Synogel Syrup: Key Information

Synogel Syrup is an oral medication primarily used to relieve digestive discomfort. It’s a combination of Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone.

Uses

Synogel Syrup is prescribed for:

• Dyspepsia (indigestion)
• Flatulence (gas) and abdominal bloating

Dosage

Adults (for Dyspepsia, Abdominal Bloating):

• Take 10-20 mL by mouth every 4-6 hours.
• It’s best taken 1 hour before or 3 hours after meals.
• Alternatively, chew 2-4 tablets every 4-6 hours, but do not exceed 12 tablets in 24 hours.

Adults (for other conditions):

• As an Antacid: Up to 1 gram per day.
• For Hyperphosphatemia in chronic renal failure: Up to 10 grams per day, divided into doses taken with meals.

Administration

• Synogel Syrup should be taken on an empty stomach.

Who Should Not Take It (Contraindications)

• Do not use if you have a known hypersensitivity (allergy) to aluminum salts.

Important Precautions

• Use with caution if you have chronic renal impairment, congestive heart failure (CHF), edema, cirrhosis, or are on a low-sodium diet.
• Patients with recent gastrointestinal hemorrhage should also use with caution.
• To minimize drug interactions, take Synogel 2-3 hours before or after any other medications.
• Pregnancy and Lactation: If you are pregnant or breastfeeding, consult your doctor before using Synogel. It’s unknown if it passes into breast milk.

Potential Drug Interactions

Synogel can affect how other medications are absorbed.

• Increased Absorption:

  • Aluminum Hydroxide: Its absorption can be increased by citrates or ascorbic acid.

• Decreased Absorption (take Synogel at least 2 hours apart from these):

  • Aluminum Hydroxide may decrease the absorption of: allopurinol, tetracyclines, quinolones, cephalosporins, bisphosphonate derivatives, corticosteroids, cyclosporine, delavirdine, iron salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, and trientine.
  • Magnesium Hydroxide may decrease the absorption of: tetracyclines and bisphosphonates.

• Simethicone: No well-documented interactions.

Possible Side Effects

Common side effects include:

• Aluminum Hydroxide: Chalky taste, constipation, fecal impaction, stomach cramps, nausea, vomiting, rebound hyperacidity, aluminum intoxication, hypophosphatemia, milk-alkali syndrome, and osteomalacia.
• Magnesium Hydroxide: Diarrhea and hypermagnesemia.
• Simethicone: Loose stools.

How It Works (Mechanism of Action)

• Aluminum Hydroxide: Works by neutralizing stomach acid (hydrochloric acid), increasing the stomach’s pH.
• Magnesium Hydroxide: Acts as a laxative by drawing water into the intestines, which softens stool and promotes bowel movements. It also neutralizes stomach acid.
• Simethicone: Reduces the surface tension of gas bubbles in the digestive system, helping them to disperse and preventing gas pockets.

Additional Information

Synogel Syrup is manufactured by Siddhartha Pharmaceuticals Pvt. Ltd. and its generic name is Aluminum Hydroxide + Magnesium Hydroxide + Simethicone. It is available in Nepal.

Disclaimer: This information about Synogel Syrup is for general knowledge and should not be used for diagnosis, medical advice, or treatment. It is not a substitute for professional medical judgment. Always consult a healthcare professional for any health concerns.