Synogel

Description

Synogel Syrup, a combination medication containing Aluminium Hydroxide, Magnesium Hydroxide, and Simethicone, is used to relieve digestive discomfort.

Uses of Synogel Syrup

Synogel Syrup is prescribed for:

• Dyspepsia (indigestion)
• Flatulence (gas)

Dosage Information

Synogel Syrup is taken orally.

Adult Dosing

• Dyspepsia, Abdominal Bloating:
  • 10-20 mL orally every 4-6 hours.
  • Take 1 hour before or 3 hours after meals.
  • Alternatively, chew 2-4 tablets every 4-6 hours, not to exceed 12 tablets per 24 hours.
• Antacid (for stomach acid relief): Up to 1 g/day.
• Hyperphosphataemia in Chronic Renal Failure: Up to 10 g/day in divided doses with meals.

Child Dosing

• Specific dosing information for children is not provided in this text.

Renal Dosing

• Specific dose adjustments for renal impairment are not provided in this text, though precautions are noted for chronic renal impairment.

Administration

Synogel Syrup should be taken on an empty stomach. Administer 2-3 hours before or after other medications to minimize potential drug interactions.

Important Considerations and Warnings

Contraindications

Do not use Synogel Syrup if you have a hypersensitivity (allergy) to aluminium salts.

Precautions

Use with caution in patients with:

• Chronic renal impairment
• Congestive heart failure (CHF)
• Oedema (swelling)
• Cirrhosis
• Patients on low sodium diets
• Patients with recent gastrointestinal hemorrhage

Pregnancy and Lactation

• Pregnancy: Use with caution.
• Lactation: It is unknown if the medication is excreted in breast milk.

Patient Counseling

• Be aware of potential drug interactions and separate administration times from other medications.

Drug Interactions

Aluminium Hydroxide

• Enhanced absorption with: Citrates or ascorbic acid.
• Decreases absorption of: Allopurinol, tetracyclines, quinolones, cephalosporins, bisphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, iron salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.

Magnesium Hydroxide

• Decreases absorption of: Tetracyclines and bisphosphonates.
• Separate administration of these and other drugs by approximately 2 hours.

Simethicone

• No well-documented interactions.

Potential Side Effects

Aluminium Hydroxide

• Chalky taste
• Constipation
• Fecal impaction
• Stomach cramps
• Nausea
• Vomiting
• Rebound hyperacidity
• Aluminium intoxication
• Hypophosphatemia (low phosphate levels)
• Milk-alkali syndrome
• Osteomalacia (softening of bones)

Magnesium Hydroxide

• Diarrhea
• Hypermagnesemia (high magnesium levels)

Simethicone

• Loose stools

Mechanism of Action

• Aluminium Hydroxide: Neutralizes stomach hydrochloric acid to form aluminum chloride salt and water, thereby increasing gastric pH.
• Magnesium Hydroxide: Acts as an osmotic laxative, drawing fluid into the bowel and causing the colon to distend, which increases peristaltic activity. It also reacts with hydrochloric acid to form magnesium chloride.
• Simethicone: Works by decreasing the surface tension of gas bubbles in the gastrointestinal system, dispersing and preventing gas pockets.

Note: Synogel 1’s Syrup is manufactured by Siddhartha Pharmaceuticals Pvt. Ltd. Its generic name is Aluminium Hydroxide + Magnesium Hydroxide + Simethicone, and it is available in Nepal. This information is not intended for diagnosis, medical advice, or treatment and should not substitute for professional medical judgment. Always consult a healthcare professional for any health concerns.