Spasonil DS

Description

Drotaverine Hydrochloride works directly on smooth muscle cells. Its primary action involves inhibiting phosphodiesterase-IV (PDE4), an enzyme found within these muscles. By blocking PDE4, Drotaverine increases the levels of cyclic AMP (cAMP) inside the cells. This elevated cAMP concentration leads to the relaxation of smooth muscles, thereby alleviating the painful spasms and helping to restore normal function. This direct mechanism provides rapid relief without the significant anticholinergic side effects sometimes seen with other antispasmodics.

Dosage Information:

Important: Always follow your doctor’s prescribed dosage and instructions.

• Adults (Oral): For its antispasmodic effect, the usual adult dose is 1 to 2 tablets (80mg to 160mg), taken 3 times daily.
• Children (Oral):
  • Children over 6 years: 1/2 to 1 tablet (40mg), 1-2 times daily.
  • Children 1-6 years: 1/4 to 1/2 tablet (20mg), 1-2 times daily.
• Administration: Spasonil DS Tablet can be taken with or without food.

(Please note: The provided information also lists injection dosages, but this specific entry is for “Spasonil DS Tablet.” The injection details are for general Drotaverine use and not directly for this tablet product.)

Important Considerations:

• Contraindications: Do not use Spasonil DS if you have severe kidney, liver, or heart dysfunction, or if you are diagnosed with a rare inherited disorder called porphyria.
• Precautions: Exercise caution and inform your doctor if you have existing renal, hepatic, or cardiac issues. It should be used cautiously during pregnancy and lactation; always consult your doctor if you are pregnant or breastfeeding.
• Drug Interactions: Drotaverine may attenuate (weaken) the action of levodopa, a medication used for Parkinson’s disease. It can have an additive beneficial effect when used concurrently with analgesics (pain relievers), antimuscarinics, or benzodiazepines. Always inform your doctor about all other medications, including over-the-counter drugs and herbal supplements, you are currently taking to avoid potential interactions.
• Adverse Effects (Side Effects): Common side effects of Drotaverine Hydrochloride include vertigo (dizziness), nausea, vomiting, and dry mouth. If these side effects persist, worsen, or if you experience any other concerning symptoms, seek medical advice promptly.