Spas Forte 20 Tablet

Description

Spas Forte 20 Tablet, containing Hyoscine Butylbromide 20mg, is manufactured by Quest Pharmaceuticals Pvt. Ltd. It is available in Nepal, typically in packs of 100 tablets, with a retail price of 20.00 NPR per tablet. This medication is primarily used to relieve spasms and associated pain in the gastrointestinal and genitourinary tracts.

Dosage Information:

• Adult Oral Dose: For gastrointestinal and genitourinary spasms, the typical adult oral dose is 20 mg, taken 4 times daily.
• Adult Parenteral Dose (IM/IV): For gastrointestinal and genitourinary spasms, adults can receive 20 mg via intramuscular (IM) or intravenous (IV) injection. This dose may be repeated after 30 minutes if needed.
  • Maximum Daily Dosage: The maximum daily dose should not exceed 100 mg.
• Child Oral Dose (6-12 years): For gastrointestinal and genitourinary spasms, children aged 6 to 12 years should take 10 mg, three times daily (tid).

Contraindications (When NOT to Use Spas Forte 20):

Do NOT use Spas Forte 20 if you have any of the following conditions:

• Narrow-angle glaucoma
• Acute haemorrhage (severe bleeding)
• Paralytic ileus (a condition where the bowel muscles don’t work properly)
• Tachycardia (rapid heart rate) due to cardiac insufficiency
• Myasthenia gravis (a chronic autoimmune neuromuscular disease)

Precautions (Use with Caution):

Inform your doctor if you have any of the following conditions, as Spas Forte 20 should be used with caution:

• Hepatic (liver) or renal (kidney) disease
• Pyloric stenosis (narrowing of the opening from the stomach to the small intestine)
• Urinary retention or prostatic hyperplasia (enlarged prostate)
• Psychosis or seizure disorders
• Ulcerative colitis
• Coronary artery disease, tachyarrhythmias, heart failure, or hypertension (high blood pressure)
• Special caution is advised for elderly individuals, children, pregnant individuals, and those who are breastfeeding.

Interactions with Other Medications:

• Additive sedative effects may occur when Spas Forte 20 is taken with alcohol or other CNS depressants.
• The effects of Spas Forte 20 may be reduced when taken concurrently with acetylcholinesterase inhibitors (such as donepezil, galantamine, rivastigmine, tacrine).
• Potentially Fatal Interaction: The effect of Hyoscine Butylbromide can be potentiated (made stronger) by other anticholinergic drugs and tricyclic antidepressants (TCAs).

Adverse Effects (Side Effects):

Side effects associated with Hyoscine Butylbromide can include:

• Cardiovascular: Flushing, postural hypotension (dizziness upon standing), tachycardia (fast heart rate), fibrillation. Rarely, psychotic reactions.
• Central Nervous System: Dizziness, drowsiness, fatigue, headache, memory loss, tremor, weakness.
• Dermatological: Dry skin, erythema (redness), increased sensitivity to light, rash.
• Gastrointestinal: Bloatedness, constipation, dry throat, dysphagia (difficulty swallowing), nausea, vomiting, xerostomia (dry mouth).
• Genitourinary: Dysuria (painful urination), urinary retention.
• Ophthalmic (Eye-related): Impaired accommodation (difficulty focusing), blurred vision, cycloplegia (paralysis of the eye’s focusing muscle), dryness, narrow-angle glaucoma, increased intraocular pain, itching, photophobia (light sensitivity), pupil dilation.
• Other: Dry nose, decreased diaphoresis (sweating), heat intolerance. Ophthalmic-specific: Somnolence, dermatitis, oedema (swelling), exudate, follicular conjunctivitis, increased IOP (intraocular pressure), local irritation, photophobia, vascular and respiratory congestion.

Potentially Fatal Side Effects: In severe cases, Hyoscine Butylbromide can lead to CNS depression, coma, and circulatory and respiratory failure.

Mechanism of Action (How it Works):

Hyoscine competitively blocks muscarinic receptors in the body. This action has both central and peripheral effects, leading to the relaxation of smooth muscle and a reduction in gastric and intestinal motility (the movement of food through the digestive tract).