SOLBE-S

Description

SOLBE-S Ointment is for topical application only.

Adult Dosage:

• Acne; Hyperkeratotic and scaling skin conditions: Apply more than 3 times daily.
• Warts and calluses: Apply as directed by a healthcare professional.

Important Considerations

Contraindications:

• Do not use SOLBE-S Ointment if you have a hypersensitivity to any of its ingredients.

Precautions:

• Do not use for prolonged periods in high concentrations or on large areas of the body.
• Use with caution if you have impaired peripheral circulation or diabetes.
• Avoid contact with broken skin, mouth, eyes, mucous membranes, and the anogenital region.

Pregnancy and Lactation:

• Information regarding use during pregnancy and lactation is not explicitly provided; consult a healthcare professional.

Interactions:

• Clobetasol Propionate: Systemic exposure to Clobetasol Propionate may increase when used with CYP3A4 inhibitors (e.g., ritonavir and itraconazole).

Potential Side Effects

Prolonged use of large amounts of clobetasol propionate and salicylic acid topically can lead to:

• Adrenal suppression, Cushing’s syndrome, diabetes, and hypertension due to sufficient systemic levels of clobetasol propionate.
• Dermal and epidermal atrophy, especially on the face.
• Steroid purpura.

How SOLBE-S Ointment Works

Clobetasol Propionate is a high-potency corticosteroid that reduces inflammation by:

• Stabilizing leukocyte lysosomal membranes.
• Preventing the release of destructive acid hydrolases from leukocytes.
• Inhibiting macrophage accumulation in inflamed areas.
• Reducing leukocyte adhesion to capillary endothelium.
• Reducing capillary wall permeability and edema formation.
• Decreasing complement components.
• Antagonizing histamine activity and kinin release.
• Reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation.

Salicylic Acid has a potent keratolytic action (helps shed dead skin cells) and a slight antiseptic effect when applied topically. It works by:

• Softening and destroying the stratum corneum (the outermost layer of skin) by increasing endogenous hydration.
• Causing the horny layer of the skin to swell, soften, and then desquamate (peel off).
• At high concentrations, salicylic acid has a caustic effect.
• It also possesses weak antifungal and antibacterial activity.