Sk Cef

Description

Sk Cef Drop (Cephradine)

Sk Cef Drop contains Cephradine and is made by Eskayef Bangladesh Ltd. It comes in a 15ml pack size and is available in Nepal for ₨ 94.00 NPR. Other forms of Cephradine, such as 250mg and 500mg capsules, and D Syrup, are also available under different brands.

What It’s Used For (Indications)

Sk Cef Drop is an antibiotic used to treat various bacterial infections, including:

• Respiratory Tract Infections: Pneumonia, Pharyngitis (sore throat), Tonsillitis, and Otitis media (ear infections).
• Skin and Soft Tissue Infections: Including those affecting the skin.
• Urinary Tract Infections: Including acute prostatitis and genitourinary tract infections.
• Other Susceptible Infections: Such as those related to Rheumatic fever.
• It’s also used for Surgical Prophylaxis (to prevent infections during surgery).

Dosage Information

• Adults (Oral):
  • General Susceptible Infections: 1-2 grams per day, divided into 2-4 doses. The maximum daily dose is 4 grams.
  • Surgical Prophylaxis: 1-2 grams before surgery. Additional doses may be given as needed.
  • Skin & Respiratory Tract Infections: Typically 250 mg every 6 hours or 500 mg every 12 hours.
  • Lobar Pneumonia: 500 mg every 6 hours or 1 gram every 12 hours.
  • Urinary Tract Infection: Usually 500 mg every 12 hours.
  • Gastrointestinal Tract Infection: 500 mg three to four times daily.
• Adults (IV/IM – for severe infections): 2-4 grams per day, divided into 4 doses. The maximum daily dose is 8 grams.
• Children (Oral): The usual total dose is 25-50 mg/kg/day, given in 2-4 equally divided doses.
• Children (Injection): 50-100 mg/kg/day in 4 equally divided doses. The total dose can be increased up to 200-300 mg/kg/day if necessary.
• Perioperative Prophylaxis (Children): The recommended dose is 1-2 grams via intramuscular (IM) or intravenous (IV) route; subsequent parenteral or oral doses are given as appropriate.
• Kidney Impairment: Dose adjustments are crucial.
  • For patients on chronic intermittent hemodialysis: 250 mg at the start of the session, repeated after 6-12 hours, then again 36-48 hours after the initial dose, and again at the start of the next hemodialysis if more than 30 hours have passed since the previous dose.
  • Creatinine Clearance (CrCl):

    • 20 ml/min: 500 mg every 6 hours.

    • 5-20 ml/min: 250 mg every 6 hours.
    • <5 ml/min: 250 mg every 12 hours.

How to Administer

• Can be taken with or without food. Taking it with meals may help reduce stomach discomfort.
• Parenteral doses (IV/IM): Administer as a deep IM injection or a slow IV injection over 3-5 minutes, or via IV infusion.
• Reconstitution (for injection forms):
  • IM: Add 2 mL or 4 mL of sterile water for injection or 0.9% NaCl injection to a 500 mg or 1 g vial, respectively.
  • IV: Add 5 mL of sterile water for injection, 5% dextrose injection, 0.9% NaCl injection, or other suitable solution to a 500 mg vial. Shake the solution well.

Important Warnings & Precautions

• Don’t use if: You are hypersensitive to cephradine or other cephalosporins, or if you have porphyria.
• Use with caution if: You have kidney impairment, a history of penicillin sensitivity, are pregnant, or are breastfeeding (the drug enters breast milk in low concentrations, so use with caution).
• Drug Interactions:
  • Increased risk of kidney toxicity when taken with loop diuretics.
  • Probenecid can decrease the renal clearance of cephradine.
• Side Effects:
  • Common side effects include diarrhea, nausea, vomiting.
  • Other effects: Leukopenia (low white blood cells), neutropenia, eosinophilia, rash, pruritus (itching), joint pain, increased BUN and creatinine, dizziness.
  • Potentially Fatal: Pseudomembranous colitis (a severe colon inflammation).

How It Works (Mechanism of Action)

Cephradine is a first-generation cephalosporin antibiotic. It works by binding to specific proteins (penicillin-binding proteins or PBPs) in the bacterial cell wall. This action inhibits the final steps of peptidoglycan synthesis, which is essential for building the bacterial cell wall. By disrupting this process, Cephradine arrests cell wall synthesis, ultimately leading to bacterial cell death.

This information about Sk Cef Drop is for general reference only and is not intended as medical advice or a substitute for professional judgment. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or medication.