Samverin

Description

Samverin Tablet is a medication used to treat conditions characterized by spasms of the gastrointestinal (GI) tract.

Here’s a detailed breakdown of its features:

Indications (Uses):

• Irritable Bowel Syndrome (IBS): Samverin Tablet is prescribed to help alleviate the various symptoms associated with Irritable Bowel Syndrome, such as abdominal pain, cramping, and general discomfort.
• Gastrointestinal Tract Spasm: It is also effective in relieving general spasmodic conditions within the digestive system.

Dosage:

• Adults (Oral):
  • For standard tablets (135 mg): The typical adult dose is one 135 mg tablet taken three times a day (tid). The dosage may be gradually decreased after several weeks once the desired therapeutic effect is achieved and symptoms improve.
  • As modified-release Capsule (200 mg): If a modified-release capsule formulation of Mebeverine Hydrochloride is available, the usual dosage is 200 mg taken twice a day (bid).

Administration:

• Samverin Tablet is administered orally (taken by mouth).

Contraindications (When not to use):

• Paralytic ileus: Samverin Tablet is contraindicated in patients diagnosed with paralytic ileus, a condition where the normal muscular contractions of the bowel are temporarily absent, leading to a functional blockage.

Precautions (Things to be aware of):

• Porphyria: Caution should be exercised when prescribing Samverin Tablet to patients with porphyria, a group of rare genetic disorders that can affect the nervous system or skin.
• Allergic Reaction: Patients with a known history of allergic reaction to Mebeverine Hydrochloride or any other medication within the same pharmacological group should use this medication with caution.

Pregnancy and Lactation:

• The provided information does not contain specific guidelines regarding the use of Samverin Tablet during pregnancy or lactation. It is essential for pregnant or breastfeeding individuals to consult a healthcare professional before taking this or any other medication.

Interactions:

• No specific drug interactions are listed in the provided information. Patients should always inform their doctor or pharmacist about all other medications they are currently taking, including over-the-counter drugs, supplements, and herbal remedies.

Adverse Effects (Side Effects): The common side effects associated with Mebeverine Hydrochloride include:

• Dizziness
• Headache
• Gastrointestinal disturbances (e.g., upset stomach, constipation, or diarrhea)
• Insomnia (difficulty sleeping)
• Anorexia (loss of appetite)
• Decreased heart rate
• Hypersensitivity reactions: These are allergic reactions that can manifest as:
  • Urticaria (hives, an itchy rash with raised red weals)
  • Erythematous rash (a red, inflamed skin rash)
  • Angioedema (swelling of deeper layers of the skin, often affecting the face, lips, tongue, or throat, which can be serious and potentially life-threatening if it affects breathing).

Mechanism of Action:

• Mebeverine is classified as an antispasmodic agent. Its therapeutic effect is achieved by directly relaxing the smooth muscles of the gastrointestinal tract. This action helps to reduce and relieve muscle spasms, thereby alleviating associated pain and discomfort.

Note:

• Samverin 135mg Tablet is manufactured by Samarth Life Sciences Pvt Ltd.
• Its generic name is Mebeverine Hydrochloride.
• Samverin is available in Nepal.
• The information provided is for general knowledge and is not intended to serve as a substitute for professional medical advice, diagnosis, or treatment. It is crucial to consult a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.