Rzol

Description

Rzol Capsule (Rabeprazole)

Rzol Capsule contains rabeprazole, a proton pump inhibitor (PPI) that reduces stomach acid. It’s used to treat conditions caused by too much stomach acid.

What is Rzol Capsule used for?

Rzol Capsule is prescribed for:

• Peptic Ulcer Disease: This includes ulcers in the stomach (gastric ulcer) and the upper part of the small intestine (duodenal ulcer).
• H. pylori Infection: Used as part of a combination therapy to eradicate Helicobacter pylori bacteria, which can cause ulcers.
• Gastro-oesophageal Reflux Disease (GERD): Also known as acid reflux, this includes symptoms like heartburn and acid regurgitation, as well as erosive oesophagitis (damage to the food pipe from stomach acid).
• Paediatric GERD: For children over 12 years old.
• Zollinger-Ellison Syndrome: A rare condition that causes the stomach to produce too much acid.

How to take Rzol Capsule (Dosage Information)

Rzol Capsule can be taken with or without meals.

Adult Dosing

• Gastro-oesophageal Reflux Disease (GERD):
  • Typical Treatment: 20 mg once daily for 4-8 weeks.
  • Maintenance: 10 mg or 20 mg once daily.
  • Erosive Oesophagitis: 20 mg once daily for 4-8 weeks. Can continue for another 8 weeks if needed for healing. Maintenance is 10 mg or 20 mg once daily.
  • All daily doses should be taken in the morning.
• Zollinger-Ellison Syndrome:
  • Initial Dose: 60 mg once daily in the morning.
  • Adjustments: May be increased up to a maximum of 120 mg per day. If your daily dose is over 100 mg, it should be split into two doses.
• Peptic Ulcer:
  • Duodenal Ulcer: 20 mg once daily in the morning for 4-8 weeks.
  • Gastric Ulcer: 20 mg once daily in the morning for 6-12 weeks.
• H. pylori Infection (Triple Therapy – typically for 1 week):
  • 20 mg twice daily, combined with:
    • Clarithromycin 500 mg twice daily and Amoxicillin 1 g twice daily, OR
    • Clarithromycin 250 mg twice daily and Metronidazole 400 mg twice daily.

Child Dosing

• Gastro-oesophageal Reflux Disease (GERD):
  • Children over 12 years: 20 mg once daily in the morning for up to 8 weeks.

Special Populations

• Elderly: No dosage adjustment is needed.
• Hepatic Impairment (Liver Problems): No dosage adjustment is needed.
• Renal Impairment (Kidney Problems): No dosage adjustment is needed.

Important Considerations

Do Not Take If:

• You are allergic to rabeprazole, other PPIs, or any ingredients in Rzol Capsule.

Precautions:

• Gastric Malignancy: Your doctor should rule out stomach cancer before you start treatment, as symptoms of cancer can sometimes be masked by PPIs.
• Severe Liver Impairment: Use with caution.
• Pregnancy and Lactation: If you are pregnant or breastfeeding, discuss with your doctor if Rzol is safe for you. It’s unknown if rabeprazole passes into breast milk, so caution is advised.
• Monitoring: Your doctor may monitor your magnesium levels before and during long-term use.

Potential Drug Interactions

Rzol Capsule can interact with other medications. Tell your doctor about all medicines you are taking, especially:

• Reduced effectiveness of: Ketoconazole, Itraconazole, Clopidogrel.
• Increased risk of low magnesium (hypomagnesaemia) with: Diuretics (water pills) and Digoxin.
• Increased effects of: Warfarin (may increase bleeding time), Saquinavir, Methotrexate.
• Decreased effectiveness when taken with: Sucralfate (take Rzol at least 30 minutes before Sucralfate).
• Potentially Fatal Interactions (may significantly decrease levels and effects of): Rilpivirine and Atazanavir.

Possible Side Effects

Like all medicines, Rzol Capsule can cause side effects, though not everyone gets them.

Common Side Effects (1-10%):

• Headache
• Abdominal pain
• Diarrhea
• Flatulence (gas)
• Constipation
• Pharyngitis (sore throat)
• General pain

Less Common but Serious Side Effects (Less than 1%, seek medical attention if severe):

• Agitation
• Agranulocytosis (severe drop in white blood cells)
• Alopecia (hair loss)
• Anemia
• Angioedema (swelling under the skin)
• Chest pain
• Delirium
• Erythema (skin redness)
• Hypokalemia (low potassium)
• Hypomagnesemia (low magnesium)
• Hyponatremia (low sodium)
• Jaundice (yellowing of skin/eyes)
• Leukocytosis (high white blood cell count)
• Leukopenia (low white blood cell count)
• Migraine
• Osteoporosis-related fractures
• Rhabdomyolysis (muscle breakdown)
• Stevens-Johnson syndrome (severe skin reaction)
• Sudden death
• Toxic epidermal necrolysis (severe skin reaction)
• Abnormal taste

Note: Rzol 20 mg Capsule is manufactured by Maruti Pharma Pvt. Ltd. and is available in Nepal. This information is for general knowledge and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with a healthcare professional for any health concerns.