₨ NPR
Description
Ritonavir is a selectively competitive reversible inhibitor of HIV protease. This means it interferes with the formation of essential proteins and enzymes that the HIV virus needs to replicate. By doing so, it leads to the production of immature and non-infectious viruses, effectively limiting the further spread of the virus in the body.
Dosage Information
Ritomune Tablets should be taken with food.
- Adults with HIV Infection (Combined with other antiretrovirals):
- Initial Dose: 300 mg twice daily for 1 day.
- Gradual Increase: May increase the dose gradually by 100 mg twice daily over up to 14 days, reaching a maximum of 600 mg twice daily.
- Hepatic Impairment: Dosage reduction may be required.
- As a Pharmacokinetic Enhancer (to boost other protease inhibitors):
- Adult: 100-200 mg once or twice daily.
- Children with HIV Infection (Combined with other antiretrovirals):
- Over 2 years: 250 mg/m² twice daily.
- Increase Dose: Increase by 50 mg/m² twice daily at 2-3 day intervals, up to 400 mg/m² twice daily.
- Maximum Dose: 600 mg twice daily.
- Hepatic Impairment: Therapy should be carefully monitored in patients with moderate and severe hepatic impairment.
Important Considerations
- Contraindications: Do not use Ritomune if you have:
- Hypersensitivity (allergy) to Ritonavir.
- Severe hepatic impairment.
- Lactation: HIV-positive women should not breastfeed.
- Precautions:
- Use with caution in pregnancy and in children.
- Careful monitoring is needed for patients with hepatic impairment, diabetes mellitus (DM), hemophilia, and pancreatitis.
- Monitoring Parameters: Your doctor will monitor your glucose, lipid, uric acid levels, and blood counts.
- Ensure adequate hydration to reduce the risk of nephrolithiasis (kidney stones).
- Discontinue treatment if the patient develops hemolytic anemia.
Additional information
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