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Rintin

intin 150mg Tablet, manufactured by Radicura Pharma Pvt Ltd, contains the active ingredient Ranitidine. It’s available in Nepal and is primarily used to reduce stomach acid.

Uses of Rintin Tablet

Rintin Tablet is prescribed for various conditions related to excess stomach acid, including:

  • Dyspepsia (indigestion)
  • H. pylori infection (often in combination with other medications)
  • Benign gastric and duodenal ulceration (stomach and small intestine ulcers)
  • Gastro-oesophageal reflux disease (GERD) (heartburn and acid reflux)
  • Acid aspiration during general anesthesia (to prevent stomach acid from entering the lungs during surgery)

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Description

Rintin can be taken with or without food.

 

Adult Dosing (Oral)

 

  • Benign Gastric and Duodenal Ulceration:
    • Initial: 300 mg once daily at bedtime, or 150 mg twice daily for 4-8 weeks. For duodenal ulcers, 300 mg twice daily for 4 weeks may be used for improved healing.
    • Maintenance: 150 mg once daily at bedtime.
    • Maximum: 300 mg twice daily.
  • Hypersecretory Conditions:
    • Initial: 150 mg two or three times daily, may be increased if needed.
    • Maximum: 6 grams daily.
  • Gastro-oesophageal Reflux Disease (GERD):
    • 150 mg twice daily or 300 mg at bedtime for up to 8 weeks.
    • In severe cases, may be increased to 150 mg four times daily for 12 weeks.
  • Dyspepsia:
    • Chronic episodic: 150 mg twice daily for up to 6 weeks.
    • Short-term symptomatic relief: 75 mg, repeated if necessary up to 4 doses daily. Maximum duration: 2 weeks of continuous use.
  • Erosive Oesophagitis:
    • Initial: 150 mg four times daily.
    • Maintenance: 150 mg twice daily.
  • NSAID-associated Ulceration:
    • Treatment: 150 mg twice daily or 300 mg at bedtime for 8-12 weeks.
    • Prevention: 150 mg twice daily.

 

Child Dosing (Oral)

 

  • Benign Gastric and Duodenal Ulceration (1 month to 16 years):
    • Treatment: 4-8 mg/kg daily in two divided doses. Maximum: 300 mg/day. Duration: 4-8 weeks.
    • Maintenance: 2-4 mg/kg once daily. Maximum: 150 mg/day.
  • Gastro-oesophageal Reflux Disease (1 month to 16 years):
    • 5-10 mg/kg daily in two divided doses. Maximum: 300 mg/day.
  • Erosive Oesophagitis (1 month to 16 years):
    • 5-10 mg/kg daily in two divided doses. Maximum: 600 mg/day.

 

Renal Dosing (Oral)

 

  • Creatinine Clearance (CrCl) <50 mL/min: 150 mg daily at bedtime. Adjust dose cautiously if necessary.

 

Parenteral Administration (IV)

 

  • Direct injection: 50 mg diluted to at least 20 mL with compatible IV fluid and given over at least 5 minutes (4 mL/min).
  • Intermittent infusion: 50 mg added to at least 100 mL of compatible IV solution and infused over 15-20 minutes.
  • Continuous infusion: 150 mg diluted in 250 mL of IV fluid and infused at 6.25 mg/hr for 24 hours. Individual doses may be reduced to 25 mg.

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