RECOSULIN-M30 (30/70)

Description

RECOSULIN-M30 (30/70): A Premixed Human Insulin for Diabetes Management

RECOSULIN-M30 (30/70) is a brand of biphasic human insulin used to manage blood sugar levels in individuals with diabetes mellitus (both Type 1 and Type 2). The “30/70” indicates that it’s a premixed formulation containing:

• 30% Soluble Human Insulin (Short-Acting/Regular Insulin): This component works quickly to lower blood sugar, typically within 30 minutes after injection. It’s designed to cover the rise in blood glucose that occurs after meals.
• 70% Isophane Human Insulin (NPH – Intermediate-Acting): This part has a longer duration of action due to its combination with protamine. It provides sustained insulin release to control blood sugar levels between meals and overnight.

This combination offers a dual action, providing both rapid post-meal coverage and a more prolonged basal effect, simplifying the insulin regimen compared to separate injections of short and intermediate-acting insulins.

Key Features and Benefits:

• Convenience: As a premixed insulin, it reduces the number of daily injections needed for comprehensive blood sugar control.
• Dual Action: Effectively targets both immediate post-meal glucose spikes and provides sustained insulin throughout the day and night.
• Human Insulin: Identical in structure to the insulin naturally produced by the human body.
• Improved Glycemic Control: Helps in maintaining stable blood glucose levels, which is crucial for preventing and delaying long-term diabetes complications affecting the eyes, kidneys, nerves, and cardiovascular system.

Onset, Peak, and Duration of Action (General):

• Onset of Action: Approximately 30 minutes.
• Peak Effect: Typically between 2 and 8 hours.
• Duration of Action: Can last for about 18 to 24 hours.

Important Usage and Administration:

• Subcutaneous Injection Only: RECOSULIN-M30 is administered by injecting it under the skin (subcutaneously). Common injection sites include the abdomen, thigh, upper arm, or buttocks. It should never be injected intravenously (into a vein) or intramuscularly (into a muscle).
• Thorough Mixing is CRUCIAL: As it is a suspension, the vial (or cartridge/pen, if applicable) must be gently rolled between the palms at least 10 times and then inverted (turned upside down and back up) at least 10 times immediately before every injection until the contents are uniformly cloudy white or milky. Do not shake vigorously, as this can create foam and affect dose accuracy.
• Timing of Injection: It is typically administered approximately 30 minutes before a meal. Ensure a meal containing carbohydrates is consumed within this timeframe to prevent hypoglycemia.
• Concentration: RECOSULIN-M30 is commonly available in 100 IU/ML concentration, though some regions might have 40 IU/ML vials. It is absolutely vital to use the correct syringe (e.g., U-100 syringe for 100 IU/ML insulin, U-40 syringe for 40 IU/ML insulin) to ensure accurate dosing. Using the wrong syringe can lead to a dangerous over- or under-dose.
• Individualized Dosage: The precise dose and frequency of injections are determined by your healthcare provider based on your individual blood glucose monitoring results, dietary habits, physical activity, and overall treatment plan.
• Injection Site Rotation: To prevent skin changes like lipodystrophy (skin thickening or pitting) and lumps, it is essential to rotate injection sites regularly within the chosen injection area.
• Never Share: Vials, cartridges, or pens and needles are for single-patient use only. Sharing can lead to the transmission of infections.

Storage:

• Unopened: Store in a refrigerator (2°C – 8°C). Do not freeze. Do not use if it has been frozen.
• Opened (In-Use): Once opened or in use, the insulin can typically be kept at room temperature (below 30°C) for a specific duration (often up to 28 days or 4 weeks, check product-specific instructions). Do not refrigerate an in-use vial/cartridge/pen. Protect from direct light and heat.
• Remove Needle After Use: Always remove the needle after each injection to prevent air from entering and insulin from leaking.

Potential Side Effects:

The most common and serious side effect is hypoglycemia (low blood sugar). Symptoms can include:

• Sweating, cold sweats
• Shakiness, trembling
• Dizziness, lightheadedness, headache
• Confusion, irritability, anxiety
• Rapid heartbeat
• Intense hunger
• Blurred vision

It is crucial to be prepared to treat hypoglycemia immediately with a fast-acting source of sugar (e.g., glucose tablets, fruit juice, regular soda).

Other possible side effects include:

• Injection site reactions: Pain, redness, itching, swelling, or bruising at the injection site.
• Lipodystrophy/Lumps under the skin: Changes in the fatty tissue under the skin at injection sites if not rotated.
• Weight gain.
• Peripheral edema (swelling of hands and feet).
• Allergic reactions: Rarely, severe generalized allergic reactions (e.g., widespread rash, difficulty breathing, wheezing) can occur and require immediate medical attention.
• Hypokalemia (low blood potassium): Insulin can cause a shift of potassium into cells.

Important Warnings and Precautions:

• Blood Glucose Monitoring: Regular and consistent monitoring of blood glucose levels is essential.
• Medical Supervision: Always use RECOSULIN-M30 under the guidance of a healthcare professional. Do not change your dose or type of insulin without consulting your doctor.
• Medication Interactions: Inform your doctor about all medications you are taking, as many can affect blood sugar levels and insulin requirements.
• Alcohol Consumption: Alcohol can significantly affect blood sugar levels and increase the risk of hypoglycemia.
• Driving/Operating Machinery: Be cautious if you experience symptoms of hypoglycemia, as your ability to concentrate and react may be impaired.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as insulin needs may change.

RECOSULIN-M30 (30/70) is an important part of diabetes management, but its safe and effective use relies on strict adherence to medical advice, proper administration techniques, and diligent blood glucose monitoring