Propilan

Description

Propilan Capsule

Propilan Capsule, with the generic name Lansoprazole, is a medication manufactured by Glenmark Pharmaceuticals Ltd. It’s available in Nepal.

Uses (Indications)

Propilan Capsule is used to treat conditions related to stomach acid, including:

• Peptic ulcers (duodenal and gastric ulcers)
• H. pylori infection (in combination therapy)
• Gastro-oesophageal reflux disease (GERD)
• Hypersecretory conditions (like Zollinger-Ellison syndrome)
• Acid-related dyspepsia (indigestion)
• NSAID-induced ulcers (ulcers caused by non-steroidal anti-inflammatory drugs)
• Erosive oesophagitis (inflammation and erosion of the esophagus)

How it Works (Mechanism of Action)

Lansoprazole is a proton pump inhibitor (PPI). It works by blocking the final step of acid production in the stomach by inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells. This reduces both basal (resting) and stimulated acid secretion.

Dosage Information

Propilan Capsule should be taken on an empty stomach, before meals.

Adults:

• Peptic Ulcer:
  • Duodenal ulcer: 30 mg once daily in the morning for up to 4 weeks.
  • Gastric ulcer: 30 mg once daily in the morning for up to 8 weeks.
  • Maintenance: 15 mg once daily.
• Zollinger-Ellison Syndrome:
  • Initial: 60 mg once daily in the morning. Doses over 120 mg daily should be divided into two doses.
• Acid-Related Dyspepsia: 15-30 mg once daily in the morning for 2-4 weeks.
• Gastro-oesophageal Reflux Disease (GERD):
  • 15-30 mg once daily in the morning for 4-8 weeks.
  • Maintenance: 15-30 mg once daily, adjusted based on response.
• Prophylaxis of NSAID-induced Ulcers: 15-30 mg once daily in the morning.
• H. pylori Infection (1-week triple therapy):
  • 30 mg twice daily, combined with clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily.
  • OR: 30 mg twice daily, combined with clarithromycin 250 mg twice daily and metronidazole 400 mg twice daily.
• Erosive Oesophagitis:
  • 30 mg once daily in the morning for up to 8 weeks. An additional 8 weeks may be given if not healed.
  • Maintenance: 15 mg once daily.
• NSAID-associated Ulceration: 30 mg once daily in the morning for 4-8 weeks.
• Elderly: No dosage adjustment is typically needed.
• Hepatic Impairment (Severe): Maximum 30 mg per day.

Children:

• Gastro-oesophageal Reflux Disease (GERD) & Erosive Oesophagitis:
  • 1-11 years:
    • Under 30 kg: 15 mg once daily in the morning for up to 12 weeks.
    • Over 30 kg: 30 mg once daily in the morning for up to 12 weeks.
    • Doses may be increased up to 30 mg twice daily if symptoms persist after 2 or more weeks of treatment.
  • 12-17 years: 15 mg once daily for up to 8 weeks (for GERD); 30 mg once daily for up to 8 weeks (for erosive oesophagitis).

Renal Impairment: No dosage adjustment is needed.

Important Considerations

Do Not Use If You Have (Contraindications):

• Known hypersensitivity to lansoprazole or any components of the capsule.

Use with Caution If You Have (Precautions):

• Hepatic impairment (liver problems).
• Gastric malignancy (stomach cancer) must be ruled out before starting treatment, as symptoms of gastric cancer can be masked by Propilan.
• Pregnancy and lactation. If breastfeeding, it’s not known if Lansoprazole is distributed into breast milk, so nursing is generally not recommended.

Potential Drug Interactions

• Increased Risk of Hypomagnesaemia: When used with diuretics and digoxin.
• Decreased Plasma Concentration: May reduce the effectiveness of erlotinib, dasatinib, and lapatinib.
• Decreased Bioavailability: May reduce the absorption of itraconazole and ketoconazole.
• Increased Plasma Concentration: May increase the levels of cilostazol and methotrexate in the blood.
• Reduced Bioavailability: Antacids and sucralfate can reduce the absorption of Propilan; take Propilan at least 30 minutes before antacids or sucralfate.
• Potentially Fatal: May significantly decrease the serum levels and pharmacological effects of rilpivirine and atazanavir.

Possible Side Effects (Adverse Effects)

Common side effects (1-10%):

• Headache (3-7%)
• Diarrhea (1-5%)
• Constipation (1-5%)
• Nausea (1-3%)
• Abdominal pain (1-3%)

Less common side effects (<1%):

• Anxiety
• Angina, palpitations, syncope (fainting), edema (swelling)
• Anorexia (loss of appetite), dry mouth, tenesmus (straining during bowel movements), flatulence (gas), melena (dark, tarry stools)
• Myalgia (muscle pain)
• Tinnitus (ringing in the ears)
• Allergic reactions

Disclaimer: This information about Propilan Capsule is for general knowledge and informational purposes only and does not constitute medical advice. It is not intended for diagnosis, treatment, or to be a substitute for the professional judgment of a healthcare provider. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.