Peptica Gel

Peptica Gel Gel: Key Information

Generic Name: Aluminium Oxide + Magnesium Hydroxide + Simethicon

Manufacturer: Geno Pharmaceuticals Ltd.

Availability: Nepal

Uses (Indications): Peptica Gel Gel is used to treat conditions such as:

• Hyperacidity
• Gastric ulcers
• Duodenal ulcers
• Gastritis

Dosage and Administration:

• Adults: Chew 1-2 tablets or take 2-4 teaspoonfuls (tsf) after meals and at bedtime as needed. Do not exceed 4 doses per day.
• Children & Renal Patients: Dosing information for these groups is not provided.
• Administration: Take after meals and at bedtime. For optimal results, follow each dose with a half glass of water or other liquid.

Contraindications: Peptica Gel Gel should not be used in cases of:

• Hypophosphataemia
• Renal failure (due to Simethicon)
• Severely debilitated patients (due to Simethicon)
• First trimester of pregnancy (due to Simethicon)

Precautions: Use with caution in patients with:

• Renal dysfunction
• Those on a low phosphate diet
• Avoid prolonged use.

Pregnancy & Lactation: Specific information beyond the contraindication of Simethicon in the first trimester of pregnancy is not detailed.

Drug Interactions:

• Aluminium Hydroxide:
  • Increased absorption with: Citrates or ascorbic acid.
  • Decreased absorption of: Allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, iron (Fe) salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, and trientine.
• Magnesium Hydroxide:
  • Decreased absorption of: Tetracyclines and biphosphonates.
  • It is recommended to separate the administration of magnesium hydroxide and other medications by approximately 2 hours.
• Simethicon: No significant drug interactions are well-documented.

Adverse Effects (Side Effects): Common side effects of the combination of Aluminium Oxide, Magnesium Hydroxide, and Simethicon may include:

• Diarrhoea
• Constipation
• Nausea
• Vomiting

Mechanism of Action:

• Aluminum Hydroxide: Works by neutralizing stomach hydrochloric acid, forming aluminum chloride (AlCl3) and water, thereby increasing gastric pH.
• Magnesium Hydroxide: Promotes bowel evacuation by drawing fluid into the colon (osmotic retention), which distends the colon and increases peristaltic activity. It also reacts with hydrochloric acid to form magnesium chloride.
• Simethicone: Reduces the surface tension of gas bubbles in the gastrointestinal system, helping to disperse and prevent gas pockets.

Disclaimer: This information, sourced from the Farmaco Nepal drug index, is for general knowledge only and is not intended for diagnosis, medical advice, or treatment. It should not be used as a substitute for professional medical judgment.