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Pansure
Pansure Tablet, manufactured by Albert David Ltd., contains Pantoprazole Sodium Sesquihydrate. It is available in 20mg and 40mg strengths and is a proton pump inhibitor (PPI) that reduces stomach acid production.
Key Information about Pansure Tablet
Uses
Pansure Tablet is prescribed for various conditions related to excessive stomach acid, including:
- Peptic ulcer disease
- H. pylori infection
- Gastro-oesophageal reflux disease (GERD)
- Zollinger-Ellison syndrome
- Oesophagitis
- Acid-related dyspepsia
- NSAID-associated ulceration
- Ulcers resistant to H2 receptor antagonists
- Gastrointestinal (GI) bleeding from stress
- Prophylaxis for acid aspiration syndrome during induction of anesthesia
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Ask about productDescription
Pansure Tablet is not recommended if you are:
- Concomitantly using rilpivirine, atazanavir, or nelfinavir.
- Lactating.
Precautions
- Gastric malignancy should be ruled out before starting treatment.
- Consider zinc supplementation during IV therapy if you are prone to zinc deficiency.
- Pregnancy: Use with caution.
- Monitoring: Magnesium levels should be monitored before initiation and periodically during prolonged use.
- Lactation: It’s not known if pantoprazole is distributed into breast milk; therefore, it’s not recommended during lactation.
Interactions
Pansure may interact with other medications, potentially leading to:
- Increased risk of digoxin-induced cardiotoxic effects.
- Increased risk of hypomagnesaemia with diuretics.
- May increase INR and prothrombin time of warfarin.
- May increase serum concentration of methotrexate and saquinavir.
- Delayed absorption and decreased bioavailability with sucralfate.
- Decreased absorption of ketoconazole and itraconazole.
- Potentially Fatal: May decrease serum levels and pharmacological effects of rilpivirine, atazanavir, and nelfinavir.
Side Effects
Common side effects (1-10% occurrence) include:
- Headache (>4%)
- Abdominal pain (4%)
- Diarrhea (4%)
- Chest pain (4%)
- Pruritus (4%)
- Rash (4%)
- Vomiting (>4%)
- Constipation (<4%)
- Facial edema (<4%)
- Generalized edema (<2%)
- Flatulence (<4%)
- Hyperglycemia (1%)
- Nausea (1%)
- Photosensitivity (<2%)
Less common but potentially serious side effects (frequency not defined) include:
- Angioedema
- Atrophic gastritis
- Anterior ischemic optic neuropathy
- Hepatocellular damage leading to hepatic failure
- Interstitial nephritis
- Pancreatitis
- Pancytopenia
- Rhabdomyolysis
- Risk of anaphylaxis
- Stevens-Johnson syndrome
- Fatal toxic epidermal necrolysis
- Erythema multiforme
Mechanism of Action
Pantoprazole is a proton pump inhibitor (PPI). It works by blocking the H+/K+ ATPase enzyme system in the gastric parietal cells. This action inhibits the final step of acid secretion, reducing both basal (continuous) and stimulated acid production in the stomach.
Additional information
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