Normogel OS

Normogel OS Suspension

Generic Name: Aluminium Hydroxide + Magnesium Hydroxide + Simethicone

Manufacturer: Deurali Janta Pharmaceuticals Pvt. Ltd.

Availability: Available in Nepal.

Therapeutic Class: Antacid, Anti-flatulent

Indications & Uses: Normogel OS Suspension is indicated for the symptomatic relief of:

• Dyspepsia: Indigestion, heartburn, and sour stomach.
• Flatulence / Abdominal Bloating: Excess gas in the digestive system.

Dosage & Administration:

• Adult Dose:

  • Dyspepsia, Abdominal Bloating: 10-20 mL orally every 4-6 hours. This should be taken either 1 hour before meals or 3 hours after meals.
  • Alternatively (Tablet Form): Chew 2-4 tablets every 4-6 hours, not exceeding 12 tablets within a 24-hour period.
  • As an Antacid: Up to 1 gram per day.
  • Hyperphosphataemia in Chronic Renal Failure: Up to 10 grams per day, administered in divided doses with meals.

• Child Dose: (Information not provided in the original text, typically requires physician consultation)

• Renal Dose: (Information not provided in the original text, typically requires physician consultation)

• Administration Notes:

  • Should be taken on an empty stomach.
  • Administer 2-3 hours before or after other medications to minimize potential drug interactions.

Contraindications:

• Hypersensitivity to aluminium salts or any component of the formulation.

Precautions: Use with caution in patients with:

• Chronic renal impairment.
• Congestive Heart Failure (CHF).
• Oedema (fluid retention).
• Cirrhosis.
• Patients on low sodium diets.
• Patients with recent gastrointestinal (GI) hemorrhage.

Pregnancy & Lactation:

• Pregnancy: Use with caution.
• Lactation: Excretion into breast milk is unknown; use with caution.

Drug Interactions:

• Aluminium Hydroxide:
  • Enhanced Absorption: With citrates or ascorbic acid.
  • Decreased Absorption Of: Allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, iron salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
• Magnesium Hydroxide:
  • Decreased Absorption Of: Tetracyclines and biphosphonates. Separate administration of these and other drugs by approximately 2 hours.
• Simethicone: No well-documented drug interactions.

Adverse Effects: Possible side effects include:

• Aluminium Hydroxide: Chalky taste, constipation, fecal impaction, stomach cramps, nausea, vomiting, rebound hyperacidity, aluminum intoxication, hypophosphatemia, milk-alkali syndrome, osteomalacia.
• Magnesium Hydroxide: Diarrhea, hypermagnesemia.
• Simethicone: Loose stools.

Mechanism of Action:

• Aluminum Hydroxide: Acts as an antacid by neutralizing stomach hydrochloric acid to form aluminum chloride (AlCl3) salt and water, thereby increasing gastric pH.
• Magnesium Hydroxide: Functions as an antacid and laxative. It promotes bowel evacuation by causing osmotic retention of fluid in the intestines, which leads to colon distension and increased peristaltic activity. It also reacts with hydrochloric acid in the stomach to form magnesium chloride.
• Simethicone: An anti-flatulent agent that disperses and prevents the formation of gas pockets in the gastrointestinal system by decreasing the surface tension of gas bubbles, allowing them to coalesce and be more easily expelled.

Note: This information on Normogel OS Suspension is provided for general drug index purposes and is not intended for diagnosis, medical advice, or treatment. It is not a substitute for the exercise of professional medical judgment. Always consult with a healthcare professional for any medical concerns.

Other Brands (containing Aluminium Hydroxide + Magnesium Hydroxide + Simethicone):

• ormogel OS Suspension

  Generic Name: Aluminium Hydroxide + Magnesium Hydroxide + Simethicone

  Manufacturer: Deurali Janta Pharmaceuticals Pvt. Ltd.

  Availability: Available in Nepal.

  Therapeutic Class: Antacid, Anti-flatulent

  Indications & Uses: Normogel OS Suspension is indicated for the symptomatic relief of:

  • Dyspepsia: Indigestion, heartburn, and sour stomach.
  • Flatulence / Abdominal Bloating: Excess gas in the digestive system.

  Dosage & Administration:

  • Adult Dose:

    • Dyspepsia, Abdominal Bloating: 10-20 mL orally every 4-6 hours. This should be taken either 1 hour before meals or 3 hours after meals.
    • Alternatively (Tablet Form): Chew 2-4 tablets every 4-6 hours, not exceeding 12 tablets within a 24-hour period.
    • As an Antacid: Up to 1 gram per day.
    • Hyperphosphataemia in Chronic Renal Failure: Up to 10 grams per day, administered in divided doses with meals.

  • Child Dose: (Information not provided in the original text, typically requires physician consultation)

  • Renal Dose: (Information not provided in the original text, typically requires physician consultation)

  • Administration Notes:

    • Should be taken on an empty stomach.
    • Administer 2-3 hours before or after other medications to minimize potential drug interactions.

  Contraindications:

  • Hypersensitivity to aluminium salts or any component of the formulation.

  Precautions: Use with caution in patients with:

  • Chronic renal impairment.
  • Congestive Heart Failure (CHF).
  • Oedema (fluid retention).
  • Cirrhosis.
  • Patients on low sodium diets.
  • Patients with recent gastrointestinal (GI) hemorrhage.

  Pregnancy & Lactation:

  • Pregnancy: Use with caution.
  • Lactation: Excretion into breast milk is unknown; use with caution.

  Drug Interactions:

  • Aluminium Hydroxide:
    • Enhanced Absorption: With citrates or ascorbic acid.
    • Decreased Absorption Of: Allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, iron salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
  • Magnesium Hydroxide:
    • Decreased Absorption Of: Tetracyclines and biphosphonates. Separate administration of these and other drugs by approximately 2 hours.
  • Simethicone: No well-documented drug interactions.

  Adverse Effects: Possible side effects include:

  • Aluminium Hydroxide: Chalky taste, constipation, fecal impaction, stomach cramps, nausea, vomiting, rebound hyperacidity, aluminum intoxication, hypophosphatemia, milk-alkali syndrome, osteomalacia.
  • Magnesium Hydroxide: Diarrhea, hypermagnesemia.
  • Simethicone: Loose stools.

  Mechanism of Action:

  • Aluminum Hydroxide: Acts as an antacid by neutralizing stomach hydrochloric acid to form aluminum chloride (AlCl3) salt and water, thereby increasing gastric pH.
  • Magnesium Hydroxide: Functions as an antacid and laxative. It promotes bowel evacuation by causing osmotic retention of fluid in the intestines, which leads to colon distension and increased peristaltic activity. It also reacts with hydrochloric acid in the stomach to form magnesium chloride.
  • Simethicone: An anti-flatulent agent that disperses and prevents the formation of gas pockets in the gastrointestinal system by decreasing the surface tension of gas bubbles, allowing them to coalesce and be more easily expelled.

  Note: This information on Normogel OS Suspension is provided for general drug index purposes and is not intended for diagnosis, medical advice, or treatment. It is not a substitute for the exercise of professional medical judgment. Always consult with a healthcare professional for any medical concerns.

  Other Brands (containing Aluminium Hydroxide + Magnesium Hydroxide + Simethicone):

  • Syrup: Synogel 1’s (manufactured by Siddhartha Pharmaceuticals Pvt. Ltd.)Syrup: Synogel 1’s (manufactured by Siddhartha Pharmaceuticals Pvt.