Nemox

Description

Nemox Dry Syrup: Amoxicillin 125mg/5ml

Nemox Dry Syrup is an antibiotic containing Amoxicillin 125mg/5ml, manufactured by National Healthcare Pvt. Ltd. It’s available in Nepal for 80.00 NPR.

What is it Used For? (Indications)

Nemox Dry Syrup treats a variety of bacterial infections, including those affecting the:

• Respiratory Tract: Pharyngitis, acute otitis media (ear infection), acute bacterial sinusitis, lower respiratory tract infections.
• Urinary & Genital Tract: Acute uncomplicated gonorrhea, chlamydial cervicitis, chlamydial urethritis, genitourinary tract infections.
• Skin & Soft Tissue: Skin and skin structure infections.
• Gastrointestinal Tract: Salmonellosis, typhoid fever, H. pylori infection (when used with other medications).
• Other: Endocarditis, anthrax, Lyme disease, dental abscesses.

How to Use (Dosage & Administration)

Nemox Dry Syrup can be taken with or without food. Taking it with meals might improve absorption and reduce stomach upset.

Adult Dosage:

• General Infections: 250-500 mg every 8 hours (oral or injectable).
• Uncomplicated Gonorrhea: 3 grams as a single oral dose, usually with probenecid.
• Dental Abscesses: 3 grams orally, repeated once 8 hours later.
• Uncomplicated Acute Urinary Tract Infection (UTI): 3 grams orally, repeated once 10-12 hours later.
• Endocarditis Prophylaxis (before dental procedures): 2 or 3 grams as a single oral dose, 1 hour before the procedure.
• Severe or Recurrent Respiratory Tract Infections: 3 grams orally twice daily.
• H. pylori Infection: 500 mg three times a day orally, in combination with metronidazole or clarithromycin and a bismuth compound or an antisecretory drug.
• Listerial Meningitis (IV/IM): 2 grams every 4 hours for 10-14 days, with other antibiotics.

Child Dosage (Oral):

• Standard Dose: 40–45 mg/kg per day, divided every 8-12 hours.
• High Dose: 80–90 mg/kg per day (maximum 4 grams/day), divided every 12 hours.
• Penicillin-Resistant S. pneumoniae Otitis Media: 150 mg/kg per day, divided every 8 hours.

Renal Impairment Dosage:

• Creatinine Clearance (CrCl) 10-30 ml/min: 250-500 mg every 12 hours.
• CrCl <10 ml/min: 250-500 mg every 24 hours.
• Patients on Hemodialysis: 250-500 mg every 24 hours, plus an additional dose during and after each dialysis session.

Important Considerations

Contraindications:

• Do not use if you have a known hypersensitivity (allergic reaction) to amoxicillin or other penicillins.

Precautions:

• Use with caution if you have kidney or liver disease.
• Use with caution during pregnancy and lactation. Amoxicillin is excreted in breast milk.
• Special caution is needed if you have infectious mononucleosis, as it can increase the risk of rash.

Drug Interactions:

• May reduce the effectiveness of oral contraceptives.
• May increase the effect of anticoagulants (blood thinners).
• Allopurinol can increase the risk of allergic reactions.
• Probenecid increases and prolongs amoxicillin blood levels.
• Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with amoxicillin’s bactericidal effect.

Potential Side Effects (Adverse Effects)

Most side effects are mild, but some can be serious.

• Common: Hyperactivity, agitation, insomnia, dizziness; skin rashes (maculopapular rash, exfoliative dermatitis, urticaria, hypersensitivity vasculitis); diarrhea, nausea, vomiting; anemia, thrombocytopenia (low platelets), leucopenia (low white blood cells), agranulocytosis (very low white blood cells).
• Potentially Fatal: Neuromuscular hypersensitivity reactions; pseudomembranous colitis (severe colon inflammation).

How it Works (Mechanism of Action)

Amoxicillin is a penicillin-class antibiotic. It works by inhibiting the synthesis of the bacterial cell wall. Specifically, it binds to penicillin-binding proteins (PBPs), which are crucial for building the peptidoglycan layer of the cell wall. This action disrupts the cell wall, leading to bacterial lysis (cell breakdown) and death.

Other Brands: Amoxicillin is also available in tablet forms (125mg and 250

Disclaimer: This information about Nemox Dry Syrup is for general knowledge and informational purposes only, and does not constitute medical advice. It is not intended to be a substitute for professional medical judgment, diagnosis, or treatment. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.