Motigut Pared Dps

Description

Motigut Pared Dps Pediatric Drops

Motigut Pared Dps Pediatric Drops is a medication from Square Pharmaceuticals Ltd. It contains Domperidone 5 mg/ml and comes in a 15 ml bottle, costing 77.50 NPR.

It’s also available as 10mg tablets and 5 mg/5 ml oral suspension.

What is Motigut Pared Dps Used For?

Motigut Pared Dps Pediatric Drops helps treat:

• Nausea and vomiting
• Gastroparesis (slow stomach emptying)
• Non-ulcer dyspepsia (indigestion)
• Gastritis (stomach inflammation)
• It may also be used for migraine (to alleviate associated nausea) and in some cases to aid lactation

How to Administer Motigut Pared Dps

Give Motigut Pared Dps on an empty stomach, 15-30 minutes before meals.

Child Dose (Oral):

• 0.2 – 0.4 mg/kg every 4 – 8 hours daily.

Child Dose (Rectal):

• Children under 12 years and over 15 kg: 30 mg twice daily.
• Children over 12 years and over 35 kg: 60 mg twice daily.

Adult Dose (Oral):

• Nausea and vomiting: 10-20 mg every 4-8 hours (maximum 80 mg/day).
• Non-ulcer dyspepsia: 10 mg 3-4 times daily (maximum 20 mg 3-4 times daily; last dose at bedtime).
• Migraine: 20 mg every 4 hours (maximum 4 doses/24 hours).

Adult Dose (Rectal):

• Nausea and vomiting: 60 mg twice daily.

Special Populations:

• Elderly: No dosage adjustment is typically needed.
• Liver Impairment: No dosage adjustment is typically needed.
• Kidney Impairment:
  • Mild to moderate: No dosage adjustment is usually needed.
  • Severe: Dosing may need to be reduced to 1-2 times daily with prolonged treatment.

Important Considerations

Do not use Motigut Pared Dps if there’s:

• Hypersensitivity to domperidone.
• Gastrointestinal hemorrhage, obstruction, or perforation.
• A prolactin-releasing pituitary hormone condition.
• Long-term administration or routine prevention of post-operative nausea and vomiting.

Precautions: Use with caution if the child has:

• Pheochromocytoma (a rare adrenal gland tumor).
• Is under 2 years old.
• Has kidney or liver problems.
• There’s a risk of cardiac arrhythmias (irregular heartbeats) and low potassium (hypokalemia) if given intravenously.
• Pregnancy and lactation require careful consideration.

Drug Interactions:

• It might reduce the effect of bromocriptine (a medication for various conditions).
• Opioid pain relievers and antimuscarinics may lessen its gut-motility enhancing effect.
• Potentially Fatal Interaction: Taking Motigut Pared Dps with strong CYP3A4 inhibitors (like ketoconazole, erythromycin, or ritonavir) can significantly increase domperidone levels, raising the risk of severe heart rhythm problems (QT prolongation).

Possible Side Effects

Common side effects of Domperidone include:

• Drowsiness
• Involuntary movements (extrapyramidal reactions)
• Galactorrhoea (unusual milk production)
• Gynaecomastia (breast enlargement in males)
• Constipation or diarrhea
• Lassitude (lack of energy)
• Decreased libido (sex drive)
• Skin rash, itchiness

Potentially Serious Side Effects (Seek immediate medical help if observed):

• Convulsions (seizures)
• Arrhythmias and cardiac arrest (irregular heartbeat and heart stopping), especially in those with heart disease or low potassium levels.
• Hypertensive crisis (dangerously high blood pressure) in patients with pheochromocytoma.

How Motigut Pared Dps Works

Domperidone, the active ingredient, blocks dopamine receptors primarily in the gut. This action:

• Increases contractions in the esophagus and stomach.
• Improves coordination between the stomach and small intestine.
• Reduces pressure in the lower esophageal sphincter, preventing reflux.
• Overall, it speeds up stomach emptying and the movement of food through the small bowel.

Please Note: This information about Motigut Pared Dps Pediatric Drops is for general knowledge and informational purposes only. It is not intended for diagnosis, medical advice, or treatment, and should not be a substitute for professional medical judgment. Always consult a qualified healthcare professional for any health concerns or before making decisions about your medical care.