LZG 30

Description

LZG 30 Capsule

LZG 30 Capsule, with the generic name Lansoprazole, is a proton pump inhibitor (PPI) manufactured by G.D. Laboratories Pvt. Ltd. It’s available in Nepal.

Uses (Indications)

LZG 30 Capsule is used to treat conditions related to excessive stomach acid, including:

• Peptic ulcers (duodenal and gastric ulcers)
• H. pylori infection (as part of combination therapy)
• Gastro-oesophageal reflux disease (GERD)
• Hypersecretory conditions (like Zollinger-Ellison syndrome)
• Acid-related dyspepsia (indigestion)
• NSAID-induced ulcers and their prophylaxis
• Erosive oesophagitis (inflammation and erosion of the esophagus)

How it Works (Mechanism of Action)

Lansoprazole, a substituted benzimidazole, works as a proton pump inhibitor (PPI). It blocks the final step of acid secretion in your stomach by inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells. This action effectively reduces both basal (resting) and stimulated acid production.

Dosage Information

Administration: Take LZG 30 Capsule on an empty stomach, before meals.

Adults:

• Peptic Ulcer:
  • Duodenal Ulcer: 30 mg once daily in the morning for up to 4 weeks.
  • Gastric Ulcer: 30 mg once daily in the morning for up to 8 weeks.
  • Maintenance: 15 mg once daily.
• Zollinger-Ellison Syndrome (Hypersecretory Conditions): Initially, 60 mg once daily in the morning. Your dose will be adjusted as needed. Daily doses over 120 mg should be split into two doses.
• Acid-Related Dyspepsia: 15-30 mg once daily in the morning for 2-4 weeks.
• Gastro-oesophageal Reflux Disease (GERD): 15-30 mg once daily in the morning for 4-8 weeks.
  • Maintenance: 15-30 mg once daily, depending on your response.
• Prophylaxis of NSAID-Induced Ulcers: 15-30 mg once daily in the morning.
• H. pylori Infection (1-week triple therapy): 30 mg twice daily, combined with either:
  • Clarithromycin 500 mg twice daily and Amoxicillin 1 g twice daily, OR
  • Clarithromycin 250 mg twice daily and Metronidazole 400 mg twice daily.
• Erosive Oesophagitis: 30 mg once daily in the morning for up to 8 weeks. An additional 8 weeks may be given if not healed.
  • Maintenance: 15 mg once daily.
• NSAID-Associated Ulceration: 30 mg once daily in the morning for 4-8 weeks.

Elderly: No dosage adjustment is typically needed.

Hepatic Impairment: If you have severe liver impairment, the maximum dose is 30 mg per day.

Children (Oral):

• Gastro-oesophageal Reflux Disease (GERD) & Erosive Oesophagitis:
  • 1-11 years:
    • Under 30 kg: 15 mg once daily in the morning for up to 12 weeks.
    • Over 30 kg: 30 mg once daily in the morning for up to 12 weeks.
    • Your doctor may increase doses up to 30 mg twice daily if symptoms persist after 2 or more weeks of treatment.
  • 12-17 years:
    • GERD: 15 mg once daily for up to 8 weeks.
    • Erosive Oesophagitis: 30 mg once daily for up to 8 weeks.

Renal Impairment: No dosage adjustment is needed for kidney impairment.

Important Considerations

Do Not Use If You Have (Contraindications):

• Known hypersensitivity to Lansoprazole or any of its components.

Use with Caution If You Have (Precautions):

• Liver impairment.
• Your doctor should rule out gastric malignancy (stomach cancer) before starting treatment.
• Pregnancy and Lactation: Use with caution. It’s not known if Lansoprazole is distributed into breast milk; nursing is generally not recommended.

Potential Drug Interactions

• Increased Risk of Hypomagnesaemia: If taken with diuretics (water pills) and digoxin.
• Decreased Plasma Concentration: May reduce the effectiveness of erlotinib, dasatinib, and lapatinib.
• Decreased Bioavailability: May reduce the absorption of itraconazole and ketoconazole.
• Increased Plasma Concentration: May increase the levels of cilostazol and methotrexate in your blood.
• Reduced Bioavailability: Antacids and sucralfate may reduce the absorption of LZG 30; take these at different times.
• Potentially Fatal Interaction: May significantly decrease the serum levels and pharmacological effects of rilpivirine and atazanavir.

Possible Side Effects (Adverse Effects)

Common (1-10%):

• Headache (3-7%)
• Diarrhea (1-5%)
• Constipation (1-5%)
• Nausea (1-3%)
• Abdominal pain (1-3%)

Less Common (<1%):

• Anxiety, angina, palpitations, syncope (fainting), edema (swelling), anorexia (loss of appetite), dry mouth, tenesmus (straining with bowel movements), flatulence (gas), melena (dark, tarry stools), myalgia (muscle pain), tinnitus (ringing in ears), allergic reaction.

Important Note

This information on LZG 30 Capsule is for general knowledge and informational purposes only, and does not constitute medical advice. It is not intended for diagnosis, treatment, or to be a substitute for the professional judgment of a healthcare provider. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.