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LINAMET 500
LINAMET 500 is a fixed-dose combination oral antidiabetic medication containing Linagliptin 2.5 mg and Metformin Hydrochloride 500 mg. It is designed for the treatment of type 2 diabetes mellitus in adults, especially when monotherapy with Metformin or Linagliptin alone does not provide adequate glycemic control.
₨210.00
Ask about productDescription
LINAMET 500 is a fixed-dose combination oral antidiabetic medication containing Linagliptin 2.5 mg and Metformin Hydrochloride 500 mg. It is designed for the treatment of type 2 diabetes mellitus in adults, especially when monotherapy with Metformin or Linagliptin alone does not provide adequate glycemic control.
Composition
- Linagliptin 2.5 mg – DPP-4 inhibitor
- Metformin Hydrochloride 500 mg – Biguanide
- Dosage Form: Film-coated tablet
- Route of Administration: Oral
Mechanism of Action
- Linagliptin inhibits the enzyme DPP-4, thereby increasing levels of incretin hormones (GLP-1 and GIP), which regulate glucose by increasing insulin secretion and suppressing glucagon release post meals.
- Metformin reduces hepatic glucose production, enhances insulin sensitivity, and improves peripheral glucose uptake and utilization.
The combination offers a synergistic effect on glycemic control without causing significant weight gain or hypoglycemia when used alone.
Indications
LINAMET 500 is indicated for:
- Adults with type 2 diabetes mellitus
- Patients inadequately controlled on Metformin monotherapy
- As part of a comprehensive diabetes management plan including diet and exercise
Dosage and Administration
- Usual Dose: One tablet twice daily or as directed by the physician
- Administration: Take with meals to minimize gastrointestinal side effects
- Renal Function Monitoring: Recommended before and during treatment, especially in elderly patients
Storage
- Store below 30°C in a dry, cool place
- Protect from light and moisture
- Keep out of reach of children
Precautions
- Not for use in patients with type 1 diabetes or diabetic ketoacidosis
- Risk of lactic acidosis with Metformin, especially in renal impairment
- Linagliptin is generally well tolerated, but hypersensitivity reactions may occur
- Use with caution in elderly or debilitated patients
- Avoid during pregnancy and breastfeeding unless advised by a healthcare provider
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