Lanpro

Description

Lanpro Capsule

Lanpro Capsule, with the generic name Lansoprazole, is a proton pump inhibitor (PPI) manufactured by Unichem Laboratories Ltd. It’s available in Nepal.

Uses (Indications)

Lanpro Capsule is used to treat conditions caused by excessive stomach acid, including:

• Peptic ulcers (duodenal and gastric ulcers)
• H. pylori infection (in combination therapy)
• Gastro-oesophageal reflux disease (GERD)
• Hypersecretory conditions (like Zollinger-Ellison syndrome)
• Acid-related dyspepsia (indigestion)
• NSAID-induced ulcers (ulcers caused by non-steroidal anti-inflammatory drugs)
• Erosive oesophagitis (inflammation and erosion of the esophagus)

How it Works (Mechanism of Action)

Lansoprazole is a substituted benzimidazole, also known as a PPI. It works by blocking the final step of acid secretion in the stomach. It does this by inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells. This effectively reduces both basal (resting) and stimulated acid production.

Dosage Information

Always take Lanpro Capsule on an empty stomach, before meals.

Adults:

• Peptic Ulcer:
  • Duodenal Ulcer: 30 mg once daily in the morning for up to 4 weeks.
  • Gastric Ulcer: 30 mg once daily in the morning for up to 8 weeks.
  • Maintenance: 15 mg once daily.
• Zollinger-Ellison Syndrome: Start with 60 mg once daily in the morning, adjusting as needed. If the daily dose is greater than 120 mg, divide it into two doses.
• Acid-Related Dyspepsia: 15-30 mg once daily in the morning for 2-4 weeks.
• Gastro-Oesophageal Reflux Disease (GERD): 15-30 mg once daily in the morning for 4-8 weeks.
  • Maintenance: 15-30 mg once daily, adjusted based on your response.
• Prophylaxis of NSAID-Induced Ulcers: 15-30 mg once daily in the morning.
• H. pylori Infection: One-week triple therapy: 30 mg twice daily combined with clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily, OR combined with clarithromycin 250 mg twice daily and metronidazole 400 mg twice daily.
• Erosive Oesophagitis: 30 mg once daily in the morning for up to 8 weeks. An additional 8 weeks may be given if not healed.
  • Maintenance: 15 mg once daily.
• NSAID-Associated Ulceration: 30 mg once daily in the morning for 4-8 weeks.
• Elderly: No dosage adjustment is typically needed.
• Hepatic Impairment (Severe): Maximum dose is 30 mg per day.

Children:

• Gastro-Oesophageal Reflux Disease & Erosive Oesophagitis:
  • 1-11 years:
    • Weight <30 kg: 15 mg once daily in the morning for up to 12 weeks.
    • Weight >30 kg: 30 mg once daily in the morning for up to 12 weeks.
    • Note: Doses may be increased up to 30 mg twice daily if the patient is still symptomatic after 2 or more weeks of treatment.
  • 12-17 years: 15 mg once daily for up to 8 weeks (for GERD); 30 mg once daily for up to 8 weeks (for erosive oesophagitis).

Renal Impairment: No dosage adjustment is typically needed.

Important Considerations

Do Not Use If You Have (Contraindications):

• Known hypersensitivity to lansoprazole or any of its components.

Use with Caution If You Have (Precautions):

• Hepatic impairment: Your liver function should be monitored.
• Gastric malignancy: Your doctor should rule out stomach cancer before starting treatment, as Lanpro can mask symptoms.
• Pregnancy and Lactation: Consult your doctor. It’s not known if Lansoprazole is distributed into breast milk, so nursing is generally not recommended.

Potential Drug Interactions

• Increased Risk of Hypomagnesemia: With diuretics and digoxin.
• Decreased Plasma Concentration: May reduce the effectiveness of erlotinib, dasatinib, and lapatinib.
• Decreased Bioavailability: May reduce the absorption of itraconazole and ketoconazole.
• Increased Plasma Concentration: May increase the levels of cilostazol and methotrexate.
• Reduced Bioavailability: Antacids and sucralfate can reduce the absorption of Lanpro.
• Potentially Fatal Interactions: May significantly decrease the serum levels and pharmacological effects of rilpivirine and atazanavir.

Possible Side Effects (Adverse Effects)

Common (1-10%):

• Headache (3-7%)
• Diarrhea (1-5%)
• Constipation (1-5%)
• Nausea (1-3%)
• Abdominal pain (1-3%)

Less Common (<1%):

• Anxiety, angina, palpitations, syncope, edema, anorexia, dry mouth, tenesmus, flatulence, melena, myalgia, tinnitus, allergic reaction.

Disclaimer: This information about Lanpro Capsule is for general knowledge and informational purposes only and does not constitute medical advice. It is not intended for diagnosis, treatment, or to be a substitute for the professional judgment of a healthcare provider. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatmen