Lancid

Description

Lancid Capsule

Lancid Capsule, with the generic name Lansoprazole, is a proton pump inhibitor (PPI) manufactured by Micro Labs Ltd. It is available in Nepal.

Uses (Indications)

Lancid Capsule is used to treat conditions caused by excess stomach acid, including:

• Peptic ulcers (duodenal and gastric ulcers)
• Helicobacter pylori (H. pylori) infection
• Gastro-oesophageal reflux disease (GERD)
• Hypersecretory conditions (e.g., Zollinger-Ellison syndrome)
• Acid-related dyspepsia (indigestion)
• NSAID-induced ulcers (ulcers caused by non-steroidal anti-inflammatory drugs)
• Erosive oesophagitis (inflammation and erosion of the esophagus)

How It Works (Mechanism of Action)

Lansoprazole, a substituted benzimidazole, is a proton pump inhibitor (PPI). It works by blocking the final step of acid secretion in the stomach by inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells. This reduces both basal (resting) and stimulated acid production.

Dosage Information

Administration: Take Lancid Capsule on an empty stomach, before meals.

Adults:

• Peptic Ulcer:
  • Duodenal ulcer: 30 mg once daily in the morning for up to 4 weeks.
  • Gastric ulcer: 30 mg once daily in the morning for up to 8 weeks.
  • Maintenance: 15 mg once daily.
• Zollinger-Ellison Syndrome:
  • Initial: 60 mg once daily in the morning. Adjust as needed.
  • Daily doses greater than 120 mg should be divided into two doses.
• Acid-Related Dyspepsia: 15-30 mg once daily in the morning for 2-4 weeks.
• Gastro-oesophageal Reflux Disease (GERD):
  • Treatment: 15-30 mg once daily in the morning for 4-8 weeks.
  • Maintenance: 15-30 mg once daily, adjusted based on response.
• Prophylaxis of NSAID-Induced Ulcers: 15-30 mg once daily in the morning.
• H. pylori Infection (1-week triple therapy): 30 mg twice daily, combined with:
  • Clarithromycin 500 mg twice daily and Amoxicillin 1 g twice daily, OR
  • Clarithromycin 250 mg twice daily and Metronidazole 400 mg twice daily.
• Erosive Oesophagitis:
  • Treatment: 30 mg once daily in the morning for up to 8 weeks. An additional 8 weeks may be given if not healed.
  • Maintenance: 15 mg once daily.
• NSAID-Associated Ulceration: 30 mg once daily in the morning for 4-8 weeks.

Special Populations (Adults):

• Elderly: No dosage adjustment is typically needed.
• Severe Hepatic Impairment: Maximum dose is 30 mg per day.
• Renal Impairment: No dosage adjustment is typically needed.

Children (Oral):

• Gastro-oesophageal Reflux Disease & Erosive Oesophagitis:
  • 1-11 years:
    • Weight <30 kg: 15 mg once daily in the morning for up to 12 weeks.
    • Weight >30 kg: 30 mg once daily in the morning for up to 12 weeks.
    • Doses may be increased up to 30 mg twice daily if symptoms persist after 2 or more weeks of treatment.
  • 12-17 years:
    • GERD: 15 mg once daily for up to 8 weeks.
    • Erosive Oesophagitis: 30 mg once daily for up to 8 weeks.

Important Considerations

Do Not Use If You Have (Contraindications):

• Hypersensitivity (allergy) to Lansoprazole or any of its components.

Use with Caution If You Have (Precautions):

• Hepatic impairment (liver disease).
• Your doctor should rule out gastric malignancy (stomach cancer) before starting treatment.
• Pregnancy and Lactation: Use with caution. It’s not known if Lansoprazole passes into breast milk; therefore, nursing is generally not recommended.

Potential Drug Interactions

• Increased Risk of Hypomagnesaemia: If taken with diuretics and digoxin.
• Decreased Plasma Concentration: May lower the levels of erlotinib, dasatinib, and lapatinib.
• Decreased Bioavailability: May reduce the absorption of itraconazole and ketoconazole.
• Increased Plasma Concentration: May increase the levels of cilostazol and methotrexate.
• Reduced Bioavailability: Antacids and sucralfate can decrease the absorption of Lancid.
• Potentially Fatal Interactions: May significantly decrease the serum levels and pharmacological effects of rilpivirine and atazanavir.

Possible Side Effects (Adverse Effects)

Common (1-10%):

• Headache (3-7%)
• Diarrhea (1-5%)
• Constipation (1-5%)
• Nausea (1-3%)
• Abdominal pain (1-3%)

Less Common (<1%):

• Anxiety
• Angina (chest pain)
• Palpitations
• Syncope (fainting)
• Edema (swelling)
• Anorexia (loss of appetite)
• Dry mouth
• Tenesmus (straining during bowel movements)
• Flatulence (gas)
• Melena (dark, tarry stools)
• Myalgia (muscle pain)
• Tinnitus (ringing in the ears)
• Allergic reactions

Disclaimer

This information about Lancid Capsule is for general knowledge and informational purposes only, and does not constitute medical advice. It is not intended for diagnosis, treatment, or to be a substitute for the professional judgment of a healthcare provider. Always consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.