₨ NPR
Description
I-Mix can be taken with or without food. To minimize gastrointestinal discomfort, it’s advisable to take it with food or milk.
Contraindications
I-Mix is contraindicated in individuals with a known hypersensitivity to cephalosporins.
Precautions
Exercise caution if you have:
- A history of allergy to penicillins.
- Pregnancy or lactation.
- Renal failure.
- Gastrointestinal disease.
It is unknown whether Cefixime is excreted in breast milk during lactation.
Interactions
- Increased concentrations of Cefixime can occur when taken with probenecid.
- Potentially Fatal: Cefixime may increase prothrombin time when administered with anticoagulants.
Adverse Effects
Common side effects (greater than 10%) include diarrhea (16%).
Other less frequent but possible side effects include:
- Abdominal pain, Candidiasis, Dizziness, Dyspepsia, Elevated transaminases, Eosinophilia, Erythema multiforme, Fever, Flatulence, Headache, Increased blood urea nitrogen (BUN), Increased creatinine, Leukopenia, Nausea, Prolonged prothrombin time (PT), Pruritus, Pseudomembranous colitis, Rash, Serum sickness-like reaction, Stevens-Johnson syndrome, Thrombocytopenia, Urticaria, Vaginitis, and Vomiting.
- Potentially Fatal: Pseudomembranous colitis.
Mechanism of Action
Cefixime exerts its antibacterial effect by binding to penicillin-binding proteins (PBPs) in the bacterial cell wall. This action inhibits the final transpeptidation step of peptidoglycan synthesis, thereby disrupting bacterial cell wall assembly and leading to bacterial cell death.
Additional information
| form | PACK |
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