HUMALOG MIX-25 CARTAGE

Description

HUMALOG MIX-25 Cartridge: A Premixed Insulin for Diabetes Management

HUMALOG MIX-25 Cartridge is a premixed suspension of insulin lispro, designed for the treatment of diabetes mellitus in adults and children (typically those old enough to manage their insulin needs, often from 12 years of age for Mix-25, though specific age recommendations can vary by region and individual patient needs). It provides a convenient way to manage blood sugar levels by combining both a rapid-acting and an intermediate-acting component in a single injection.

Active Ingredients and How it Works:

Each milliliter of HUMALOG MIX-25 contains 100 units of insulin lispro, which is broken down into two parts:

• 25% Insulin Lispro (Rapid-Acting): This component works quickly to lower blood glucose levels, typically within 10-20 minutes after injection. It helps to control the rapid rise in blood sugar that occurs after meals. Insulin lispro is an insulin analog that has been slightly modified to allow for faster absorption into the bloodstream compared to regular human insulin.
• 75% Insulin Lispro Protamine Suspension (Intermediate-Acting): This component has a prolonged action, as the insulin lispro is combined with protamine sulfate, which slows its absorption. This part of the mixture helps to provide longer-lasting blood sugar control between meals and overnight.

The combination of these two forms of insulin lispro provides a dual action: a rapid onset for mealtime control and an extended duration for sustained blood sugar management. This makes HUMALOG MIX-25 particularly useful for individuals who prefer the convenience of a single injection to cover both mealtime and background insulin needs.

Uses:

HUMALOG MIX-25 Cartridge is used to reduce high blood sugar (glucose) levels in patients with:

• Type 1 Diabetes: Where the pancreas produces little to no insulin.
• Type 2 Diabetes: Where the body either doesn’t produce enough insulin or doesn’t use insulin effectively (insulin resistance).

Administration and Dosage:

• Cartridge Form: HUMALOG MIX-25 Cartridges are designed for use with a reusable insulin pen device, such as the HumaPen. They are not pre-filled pens themselves but require insertion into a compatible pen delivery system.
• Subcutaneous Injection: It is always injected under the skin (subcutaneously) in areas like the abdomen, thigh, or upper arm. It should never be injected directly into a vein (intravenously).
• Mixing Before Use: As it’s a suspension, the cartridge must be gently rolled between the palms at least 10 times and inverted 10 times immediately before each injection until the contents are uniformly mixed (appearing uniformly cloudy white or milky). Do not shake vigorously, as this can cause frothing and affect dose accuracy.
• Timing: HUMALOG MIX-25 is typically administered within 15 minutes before a meal. Unlike pure rapid-acting insulins like Humalog (insulin lispro), it generally should not be given after the start of a meal due to its intermediate-acting component.
• Individualized Dosage: Your doctor will determine the appropriate dose and timing based on your individual blood glucose levels, diet, physical activity, and overall treatment plan.
• Injection Site Rotation: Regularly rotating injection sites within the chosen area is crucial to prevent skin changes like lipodystrophy (lumps or depressions).

Storage:

• Unopened Cartridges: Should be stored in a refrigerator (2°C – 8°C). Do not freeze.
• In-Use Cartridges: Once a cartridge is inserted into a pen and in use, it should be kept at room temperature (below 30°C) and used within 28 days. Do not refrigerate an in-use pen and always keep the cap on to protect it from light.
• Do Not Store with Needle Attached: Always remove the needle after each injection to prevent air from entering the cartridge and insulin from leaking.
• Visual Inspection: Before each use, inspect the cartridge. The suspension should be uniformly cloudy white after mixing. Do not use if it looks clear, has solid particles, or appears frosted.

Potential Side Effects:

The most common and serious side effect is hypoglycemia (low blood sugar). Symptoms can include:

• Weakness, trembling, or shakiness
• Sweating
• Lightheadedness/headache
• Lack of concentration, confusion
• Irritability or abnormal behavior
• Blurred vision
• Fast heartbeat
• Hunger
• Numbness around the lips/fingers

It is vital to recognize and treat hypoglycemia promptly by consuming a fast-acting source of sugar (e.g., glucose tablets, fruit juice, sugary drink).

Other possible side effects include:

• Injection site reactions: Pain, redness, itching, swelling, or bruising at the injection site.
• Lipodystrophy: Skin changes (thickening or pitting) at injection sites if not rotated.
• Weight gain.
• Allergic reactions: Rare but serious reactions (e.g., rash over the whole body, difficulty breathing, wheezing, low blood pressure, rapid heartbeat). Seek immediate medical attention if these occur.
• Hypokalemia (low blood potassium): Can occur and may worsen with certain medications.

Important Warnings and Precautions:

• Never Share Needles or Cartridges: HUMALOG MIX-25 cartridges are for single-patient use only. Sharing can transmit infections.
• Do Not Mix with Other Insulins: Do not mix HUMALOG MIX-25 with any other insulin or medications in the same cartridge.
• Monitor Blood Sugar: Regular blood glucose monitoring is essential to manage your diabetes and adjust insulin doses as needed.
• Medical Supervision: Always use HUMALOG MIX-25 under the guidance of a healthcare professional. Do not change your dose or type of insulin without consulting your doctor.
• Be Prepared for Hypoglycemia: Always carry a source of fast-acting sugar.
• Driving and Operating Machinery: Be aware that your ability to concentrate and react may be impaired during episodes of hypoglycemia.
• Inform Your Doctor: Discuss all your medical conditions, current medications (including over-the-counter drugs and supplements), and lifestyle factors with your doctor. Certain conditions (e.g., kidney or liver problems) and medications can affect insulin requirements.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

HUMALOG MIX-25 Cartridge provides a flexible and effective option for managing diabetes, but careful adherence to prescribed dosage, administration techniques, and monitoring is paramount for safe and effective blood sugar control.